Clonotypic analysis of T cells infiltrating the skin of patients with atopic dermatitis: Evidence for antigen-driven accumulation of T cells

Human Immunology

Volumn 48, Issue 1-2, 1996, Pages 107-113

  Tanaka, Atsushi ^a,b   Takahama, Hideto ^a   Kato, Tomohiro ^a   Kubota, Yasuo ^a   Kurokawa, Kiyoshi ^b   Nishioka, Kusuki ^a   Mizoguchi, Masako ^a   Yamamoto, Kazuhiko ^a,c  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ADULT; ARTICLE; ATOPIC DERMATITIS; CELLULAR IMMUNITY; CLINICAL ARTICLE; FEMALE; HUMAN; LYMPHOCYTE CLONE; LYMPHOCYTIC INFILTRATION; MALE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE STRAND CONFORMATION POLYMORPHISM; SKIN INFLAMMATION; T LYMPHOCYTE;

EID: 0030175980     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/0198-8859(96)00081-X     Document Type: Article

References (20)

1. Leung D, Bhan A, Schneeberger E, Geha R: Characterization of the mononuclear cell infiltrate in atopic dermatitis using monoclonal antibodies. J Allergy Clin Immunol 71:47, 1983.
2. Menssen A, Trommler P, Vollmer S, Schendel D, Albert E, Gurtler L, Riethmuller G, Prinz JC: Evidence for an antigen-specific cellular immune response in skin lesions of patients with psoriasis vulgaris. J Immunol 155:4078, 1995.
3. Mihm M, Soter N, Dvorak H, Austen K: The structure of normal skin and the morphology of atopic eczema. J Invest Dermatol 67:305, 1976.
4. O'hehir R, Bal V, Quint D, Moqbel R, Kay A, Zanders E, Lamb J: An in vitro model of allergen-dependent IgE synthesis by human B lymphocytes: comparison of the response of an atopic and a non-atopis individual to Dermatophagoides spp. (house dust mite). Immunology 66: 499, 1989.
5. Wierenga E, Snoek M, Jansen H, Bos J, Van Lier R, Kapsenberg M: Human atopen-specific types 1 and 2 T helper cell clones. J Immunol 147:2942, 1991.
6. Wedderburn L, O'Hehir R, Hewitt C, Lamb J, Owen M: In vivo vlonal dominance and limited T-cell receptor usage in human CD4+ T-cell recognition of house dust mite allergens. Proc Natl Acad Sci USA 90:8214, 1993.
7. Yamamoto K, Sakoda H, Nakajima T, Kato T, Okubo M, Dohi M, Mizushima Y, Ito K, Nishioka K: Accumulation of multiple T cell clonotypes in the synovial lesions of patients with clonality analysis. Int Immunol 4:1219, 1992.
8. Okubo M, Kurokawa M, Nishimaki Y, Kasukawa R, Nishioka K, Yamamoto K: Clonotype analysis of the peripheral blood T cells and the autoantigen-reactive T cells from patients with mixed connective tissue disease. J Immunol 153:3784, 1994.
9. Dohi M, Yamamoto K, Masuko K, Ikeda Y, Matsuzaki G, Sugiyama H, Suko M, Okudaira H, Mizushima Y, Nishioka K, Ito K: Accumulation of multiple T cell clonotypes in lungs of healthy individuals and patients with pulmonary sarcoidosis. J Immunol 152:1983, 1994.
10. Yamamoto K, Masuko K, Takahashi S, Ikeda Y, Kato T, Mizusha Y, Hayashi K, Nishioka K: Accumulation of distinct T cell clonotypes in human solid tumors. J Immunol 154:1804, 1995.
11. Ikeda Y, Masuko K, Nakai Y, Kato T, Hasunuma T, Yoshino S, Mizushima Y, Nishioka K, Yamamoto K: High frequencies of identical T cell clonotypes in synovial tissues of rhumatoid arthritis patients suggest the occurrence of common antigen-driven immune responses. Arthritis Rheum, in press.
12. Chien Y-h, Davis MM: How αβ T-cell receptors 'see' peptide/MHC complexes. Immunol Today 14:597, 1993.
13. Ehrich EW, Devaux B, Rock EP, Jorgensen JL, Davis MM, Chien Y: T cell receptor interaction with peptide/ major histocompatibility complex (MHC) and superantigen/MHC ligands is dominated by antigen. J Exp Med 178:713, 1993.
14. Wilson DB, Steinman L, Gold DP: The V-region disease hypothesis: new evidence suggests it is probably wrong. Immunol Today 14:376, 1993.
15. Hanifin J, Rajka G: Diagnostic features of atopic dermatitis. Acta Derm Venereol (Stockholm) 92:44, 1980.
16. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Anal Biochem 162:156, 1987.
17. Choi Y, Kotzin B, Herron L, Callahan J, Marrack P, Kappler J: Interaction of Staphylococcusaureus toxin "superantigens" with human T cells. Proc Natl Acad Sci USA 86:8941, 1989.
18. Orita M, Suzuki Y, Sekiya T, Hayashi K: Rapid and sensitive detection of point mutants and DNA polymorphisms using the polymerase chain reaction. Genomics 5:874, 1989.
19. Bos JD, Zonneveld I, Das PK, Krieg SR, van der Loos CM, Kapsenberg ML: The skin immune system (SIS): distribution and immunophenotype of lymphocyte subpopulations in normal human skin. J Invest Dermatol 88:569, 1987.
20. Dunn D, Gadenne A-S, Simha S, Lerner E, Bigby M, Bleicher P: T-cell receptor Vβ expression in normal skin. Proc Natl Acad Sci USA 90:1267, 1993.