Lack of contribution of circulatory kinin elevated by captopril to induce hypotension in normotensive and hypertensive rats

Immunopharmacology

Volumn 33, Issue 1-3, 1996, Pages 291-293

  Majima, Masataka ^a   Katori, Makoto ^a   Ogino, Michiko ^a   Saito, Maki ^a   Sugimoto, Katsuhiko ^a   Adachi, Keiichi ^a   Ohno, Takashi ^a   Sunahara, Noriyuki ^b   Katoh, Koichi ^b   Tatemichi, Noriyuki ^c   Takei, Yoshifumi ^c  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^c Maruko Pharmaceutical Co Ltd   (Japan)

Author keywords

blood kinin levels; captopril; deoxycorticosterone acetate salt hypertensive rats; enzyme linked immunosorbent assay (ELISA); spontaneously hypertensive rats

Indexed keywords

BRADYKININ; CAPTOPRIL; DEOXYCORTICOSTERONE ACETATE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; KININ; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL BLOOD; BLOOD LEVEL; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEART RATE; HYPERTENSION; HYPOTENSION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

EID: 0030175733     PISSN: 01623109     EISSN: None     Source Type: Journal    
DOI: 10.1016/0162-3109(96)00044-6     Document Type: Conference Paper

References (6)

1. Bao G, Gohlke P, Quadri F, Unger T. Chronic kinin receptor blockade attenuates the antihypertensive effect of ramipril. Hypertension 1992; 20: 74-79.
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3. Majima M, Katori M, Hanazuka M, Mizogami S, Nakano T, Nakao Y, Mikami R, Uryu H, Okamura R, Mohsin SSJ, Oh-ishi S. Suppression of rat deoxycorticosterone-salt hypertension by the kallikrein-kinin system. Hypertension 1991; 17: 806-813.
4. Majima M, Shima C, Saito M, Kuribayashi Y, Katori M, Aoyagi T. Poststatin, a novel inhibitor of bradykinin-degrading enzymes in rat urine. Eur J Pharmacol 1993; 232: 181-190.
5. Majima M, Katori M. Approaches to the development of novel antihypertensive drugs: crucial role of the renal kallikrein-kinin system. Trends Pharmacol Sci 1995; 16: 239-246.
6. Nakagawa M, Nasjletti A. Plasma kinin concentration in deoxycorticosterone-salt hypertension. Hypertension 1988; 11: 411-415.