Neurotrophic factors in peripheral neuropathies: Pharmacological strategies

Progress in Neurobiology

Volumn 49, Issue 2, 1996, Pages 125-143

  Riaz, S S ^a   Tomlinson, D R ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; CATECHOLAMINE; CYTOKINE; GANGLIOSIDE; GROWTH FACTOR RECEPTOR; NERVE GROWTH FACTOR; NEUROTROPHIC FACTOR; NEUROTROPIN; PROPENTOFYLLINE; QUINONE DERIVATIVE;

AXOPLASM FLOW; HUMAN; MULTIGENE FAMILY; NERVE GROWTH; NEUROTROPISM; NONHUMAN; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; PROTEIN INDUCTION; RETROGRADE NERVE FIBER TRANSPORT; REVIEW;

EID: 0030175511     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/0301-0082(96)00010-X     Document Type: Review

References (171)

1. Angeletti, R. H. and Bradshaw, R. A. (1971) Nerve growth factor from mouse submaxillary gland: amino acid sequence. Proc. Natl. Acad. Sci. U. S. A. 68, 2417-2420.
2. Angeletti, R. H., Hermodson, M. A. and Bradshaw, R. A. (1973) Amino acid sequences of mouse 2.5S nerve growth factor. II. Isolation and characterization of the thermolytic and peptic peptides and the complete covalent structure. Biochemistry 12, 100-115.
3. Awatsuji, H., Furkawa, Y., Hirota, M., Nii, S., Furukawa, S. and Hayashi, K. (1993) Interleukin-4 and -5 as modulators of nerve growth factor synthesis/secretion in astrocytes. J. Neurosci. Res. 34, 539-545.
4. Barde, Y. A., Edgar, D. and Thoenen, H. (1982) Purification of a new neurotrophic factor from mammalian brain. EMBO J. 1, 549-553.
5. Barker, P. A. and Murphy, R. A. (1992) The nerve growth factor receptor: a multicomponent system that mediates the actions of the neurotrophin family of proteins. [Review]. Mol. Cell Biochem. 110, 1-15.
6. Barth, E. M., Korsching, S. and Thoenen, H. (1984) Regulation of nerve growth factor synthesis and release in organ cultures of rat iris. J. Cell Biol. 99, 839-843.
7. Berg, M. M., Sternberg, D. W., Hempstead, B. L. and Chao, M. V. (1991) The low-affinity p75 nerve growth factor (NGF) receptor mediates NGF-induced tyrosine phosphorylation. Proc. Natl. Acad. Sci. U.S.A. 88, 7106-7110.
8. Berkemeier, L. R., Winslow, J. W., Kaplan, D. R., Nikolics, K., Goeddel, D. V. and Rosenthal, A. (1991) Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB. Neuron. 7, 857-866.
9. Binderup, L. and Bramm, E. (1988) Effects of a novel vitamin D analogue MC903 on cell proliferation and differentiation in vitro and on calcium metabolism in vivo. Biochem. Pharmacol. 37, 889-895.
10. Bizzi, A., Crane, R. C., Autilio-Gambetti, L. and Gambetti, P. (1984) Aluminum effect on slow axonal transport: a novel impairment of neurofilament transport. J. Neurosci. 4, 722-731.
11. Bothwell, M. (1991) Keeping track of neurotrophin receptors. Cell. 65, 915-918.
12. Brimijoin, W. S. (1982) Abnormalities of axonal transport: are they a cause of peripheral nerve disease. Mayo Clin. Proc. 57, 707-714.
13. Bræ, H. and Sidenius, P. (1986) Anterograde components of axonal transport in motor and sensory nerves in experimental 2.5-hexanedione neuropathy. J. Neurochem. 47, 31-37.
14. Carman-Krzan, M., Vigé, X. and Wise, B. C. (1991) Regulation by interleukin-1 of nerve growth factor secretion and nerve growth factor mRNA expression in rat primary astroglial cultures. J. Neurochem. 56, 636-643.
15. Cattaneo, E. and McKay, R. (1990) Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor. Nature. 347, 762-765.
16. Cavanagh, J. B., Chen, F. C., Kyu, M. H. and Ridley, A. (1968) The experimental neuropathy in rats caused by p-bromophenylacetylurea. J. Neurol. Neurosurg. Psychiatry. 31, 471-478.
17. Clark, A. W., Griffin, J. W. and Price, D. L. (1980) The axonal pathology in chronic IDPN intoxication. J. Neuropathol. Exp. Neurol. 39, 42-55.
18. Cohen, P., Holmes, C. F. and Tsukitani, Y. (1990) Okadaic acid: a new probe for the study of cellular regulation. [Review]. Trends. Biochem. Sci. 15, 98-102.
19. D'Mello, S. R. and Heinrich, G. (1990) Induction of nerve growth factor gene expression by 12-O-tetradecanoyl phorbol 13-acetate. J. Neurochem. 55, 718-721.
20. De Bernardi, M. A., Fabrazzo, M. and Mocchetti, I. (1991) Transcriptional regulation of nerve growth factor synthesis. In: Neurotransmitter regulation of gene transcription. pp. 37-46. Eds. Costa E and John T. Thieme: New York.
21. Doi, Y., Shigemori, H., Ishibashi, M., Mizobe, F., Kawashima, A., Nakaike, S. and Kobayashi, J. (1993) New sesterterpenes with nerve growth factor synthesis-stimulating activity from the Okinawan marine sponge Hyrtios sp. Chem. Pharm. Bull. Tokyo. 41, 2190-2191.
22. Domenici, L., Berardi, N., Carmignoto, G., Vantini, G. and Maffei, L. (1991) Nerve growth factor prevents the amblyopic effects of monocular deprivation. Proc. Natl. Acad. Sci. U.S.A. 88, 8811-8815.
23. Ebendal, T., Larhammar, D. and Persson, H. (1986) Structure and expression of the chicken beta nerve growth factor gene. EMBO J. 5, 1483-1487.
24. Ebendal, T., Persson, H., Larhammar, D., Lundstromer, K. and Olson, L. (1989) Characterization of antibodies to synthetic nerve growth factor (NGF) and proNGF peptides. J. Neurosci. Res. 22, 223-240.
25. Eckenstein, F., Woodward, W. R. and Nishi, R. (1991) Differential localization and possible functions of aFGF and bFGF in the central and peripheral nervous systems. Ann. NY Acad. Sci. 638, 348-360.
26. Ernfors, P., Hallbook, F., Ebendal, T., Shooter, E. M., Radeke, M. J., Misko, T. P. and Persson, H. (1988) Developmental and regional expression of beta-nerve growth factor receptor mRNA in the chick and rat. Neuron. 1, 983-996.
27. Ernfors, P., Ibanez, C.F., Ebendal, T., Olson, L. and Persson, H. (1990a) Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain. Proc. Natl. Acad. Sci. USA. 87, 5454-5458.
28. Ernfors, P., Wetmore, C., Olson, L. and Persson, H. (1990b) Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family. Neuron. 5, 511-526.
29. Fernyhough, P., Diemel, L. T., Hardy, J., Brewster, W. J., Mohiuddin, L. and Tomlinson, D. R. (1995) Human recombinant nerve growth factor replaces deficient neurotrophic support in the diabetic rat. Eur. J. Neurosci. 7, 1107-1110.
30. Friede, R. L. and Samorajski, T. (1970) Axon caliber related to neurofilaments and microtubules in sciatic nerve fibers of rats and mice. Anat. Rec. 167, 379-387.
31. Fuji, K., Hiramatsu, M., Hayashi, S., Kameyama, T. and Nabeshima, T. (1993) Effects of propentofylline, a NGF synthesis stimulator, on alterations in muscarinic cholinergic receptors induced by basal forebrain lesion in rats. Neurosci. Lett. 150, 99-102.
32. Furukawa, Y., Furukawa, S., Ikeda, F., Satoyoshi, E. and Hayashi, K. (1986a) Aliphatic side chain of catecholamine potentiates the stimulatory effect of the catechol part on the synthesis of nerve growth factor. FEBS Lett. 208, 258-262.
33. Furukawa, Y., Furukawa, S. and Satoyoshi, E. (1986b) Catecholamines induce an increase in nerve growth factor content in the medium of mouse L-M cells. J. Biol. Chem. 261, 6039-6047.
34. Furukawa, Y., Furukawa, S., Satoyoshi, E. and Hayashi, K. (1987) Regulation of nerve growth factor synthesis/secretion by catecholamines in cultured mouse astroglia. Biochem. Biophys. Res. Commun. 147, 1048-1054.
35. Furukawa, Y., Tomioka, N., Sato, W., Satoyoshi, E., Hayashi, K. and Furukawa, S. (1989) Catecholamines increase nerve growth factor mRNA content in both mouse astroglial cells and fibroblast cells. FEBS Lett. 247, 463-467.
36. Furukawa, Y., Furukawa, S., Omae, F., Awatsuji, H. and Hayashi, K. (1993) Alkylcatechols regulate NGF gene expression in astroglial cells via both protein kinase C- and cAMP-independent mechanisms. J. Neurosci. Res. 35, 522-529.
37. Gadient, R. A., Cron, K. C. and Otten, U. (1990) Interleukin-1 beta and tumor necrosis factor-alpha synergistically stimulate nerve growth factor (NGF) release from cultured rat astrocytes. Neurosci. Lett. 117, 335-340.
38. Gilman, A. G. and Nirenberg, M. (1971) Effect of catecholamines on the adenosine 3′:5′-cyclic monophosphate concentrations of clonal satellite cells of neurons. Proc. Natl. Acad. Sci. U.S.A. 68, 2165-2168.
39. Gold, B. G., Griffin, J. W. and Price, D. L. (1985) Slow axonal transport in acrylamide neuropathy: different abnormalities produced by single-dose and continuous administration. J. Neurosci. 5, 1755-1768.
40. Gold, B. G., Mobley, W. C. and Matheson, S. F. (1991) Regulation of axonal caliber, neurofilamenl content, and nuclear localization in mature sensory neurons by nerve growth factor. J. Neurosci. 11, 943-955.
41. Green, S. H. and Greene, L. A. (1986) A single Mr approximately 103,000 1251-beta-nerve growth factor-affinity-labeled species represents both the low and high affinity forms of the nerve growth factor receptor. J. Biol. Chem. 261, 15316-15326.
42. Griffin, J. W., Anthony, D. C., Fahnestock, K. E., Hoffman, P. N. and Graham, D. G. (1984) 3.4-Dimethyl-2.5-hexanedione impairs the axonal transport of neurofilament proteins. J. Neurosci. 4, 1516-1526.
43. Griffin, J. W., Hoffman, P. N., Clark, A. W., Carroll, P. T. and Price, D. L. (1978) Slow axonal transport of neurofilament proteins: impairment of beta, beta'-iminodipropionitrile administration. Science. 202, 633-635.
44. Griffin, J. W. and Watson, D. F. (1988) Axonal transport in neurological disease. Ann. Neurol. 23, 3-13.
45. Hallbook, F., Ibanez, C. F. and Persson, H. (1991) Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. Neuron. 6, 845-858.
46. Hanaoka, Y., Ohi, T., Furukawa, S., Furukawa, Y., Hayashi, K. and Matsukura, S. (1992) Effect of 4-methylcatechol on sciatic nerve growth factor level and motor nerve conduction velocity in experimental diabetic neuropathic process in rats. Exp. Neurol. 115, 292-296.
47. Hanaoka, Y., Ohi, T., Furukawa, S., Furukawa, Y., Hayashi, K. and Matsukura, S. (1994) The therapeutic effects of 4-methylcatechol, a stimulator of endogenous nerve growth factor synthesis, on experimental diabetic neuropathy in rats. J. Neurol. Sci. 122, 28-32.
48. Hempstead, B. L., Martin-Zanca, D., Kaplan, D. R., Parada, L. F. and Chao, M. V. (1991) High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low affinity NGF receptor. Nature. 350, 678-683.
49. Heumann, R., Korsching, S., Scott, J. and Thoenen, H. (1984) Relationship between levels of nerve growth factor (NGF) and its messenger RNA in sympathetic ganglia and peripheral target tissues. EMBO J. 3, 3183-3189.
50. Heumann, R. and Thoenen, H. (1986) Comparison between the time course of changes in nerve growth factor protein levels and those of its messenger RNA in the cultured rat iris. J. Biol. Chem. 261, 9246-9249.
51. Hofer, M., Pagliusi, S. R., Hohn, A., Leibrock, J. and Barde, Y.-A. (1990) Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain. EMBO J. 9, 2459-2464.
52. Hoffman, P. N., Cleveland, D. W., Griffin, J. W., Landes, P. W., Cowan, N. J. and Price, D. L. (1987) Neurofilament gene expression: a major determinant of axonal caliber. Proc. Natl. Acad. Sci. USA. 84, 3472-3476.
53. Hoffman, P. N., Griffin, J. W. and Price, D. L. (1984) Control of axonal caliber by neurofilament transport. J. Cell Biol. 99, 705-714.
54. Hoffman, P. N. and Lasek, R. J. (1975) The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian neurons. J. Cell Biol. 66, 351-366.
55. trk mRNA marks NGF-responsive forebrain neurons: Evidence that trk gene expression is induced by NGF. Neuron. 9, 465-478.
56. Hosang, M. and Shooter, E. M. (1985) Molecular characteristics of nerve growth factor receptors on PC12 cells. J. Biol. Chem. 260, 655-662.
57. Houlgatte, R., Wion, D. and Brachet, P. (1989) Levels of nerve growth factor secreted by rat primary fibroblasts and iris transplants are influenced by serum and glucocorticoids. Dev. Brain Res. 47, 171-179.
58. Ibanez, C. F., Ebendal, T., Barbany, G., Murray-Rust, J., Blundell, T. L. and Persson, H. (1992) Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product. Cell. 69, 329-341.
59. Ibanez, C. F., Ebendal, T. and Persson, H. (1991) Chimeric molecules with multiple neurotrophic activities reveal structural elements determining the specificities of NGF and BDNF. EMBO J. 10, 2105-2110.
60. Ikegami, R., Furukawa, Y., Kaechi, K., Hayashi, K. and Furukawa, S. (1990) Effects of catecholamines and 4-methylcatechol on the synthesis and secretion of nerve growth factor by rat sciatic nerve segments in culture. Biomed. Res. 11, 61-65.
61. Ip, N. Y., Ibáñez, C. F., Nye, S. H., McClain, J., Jones, P. F., Gies, D. R., Belluscio, L., Le Beau, M. M., Espinosa, R. and Squinto, S. P. et al. (1992) Mammalian neurotrophin-4: Structure, chromosomal localization, tissue distribution, and receptor specificity. Proc. Natl. Acad. Sci. USA. 89, 3060-3064.
62. Isackson, P. J., Towner, M. D. and Huntsman, M. M. (1991) Comparison of mammalian, chicken and Xenopus brain-derived neurotrophic factor coding sequences. FEBS Lett. 285, 260-264.
63. Jakobsen, J. (1979) Early and preventable changes of peripheral nerve structure and function in insulin-deficient diabetic rats. J. Neurol. Neurosurg. Psych. 42, 509-518.
64. Jakobsen, J. and Brimijoin, S. (1981) Axonal transport of enzymes and labeled proteins in experimental axonopathy induced by p-bromophenylacetylurea. Brain Res. 229, 103-122.
65. Jakobsen, J. and Sidenius, P. (1980) Decreased axonal transport of structural proteins in streptozotocin diabetic rats. J. Clin. Invest. 66, 292-297.
66. Jakobsen, J. and Sidenius, P. (1983) Early and dose-dependent decrease of retrograde axonal transport in acrylamide-intoxicated rats. J. Neurochem. 40, 447-454.
67. Jakobsen, J., Sidenius, P. and Bræ, H. (1986) A proposal for a classification of neuropathies according to their axonal transport abnormalities. J. Neurol. Neurosurg. Psych. 49, 986-990.
68. Jehan, F., Neveu, I., Barbot, N., Binderup, L., Brachet, P. and Wion, D. (1991) MC903. an analogue of 1,25-dihydroxyvitamin D3, increases the synthesis of nerve growth factor. Eur. J. Pharmacol. 208, 189-191.
69. Jing, S., Tapley, P. and Barbacid, M. (1992) Nerve growth factor mediates signal transduction through trk homodimer receptors. Neuron. 9, 1067-1079.
70. Johnson, D., Lanahan, A., Buck, C. R., Sehgal, A., Morgan, C., Mercer, E., Bothwell, M. and Chao, M. (1986) Expression and structure of the human NGF receptor. Cell. 47, 545-554.
71. Kaechi, K., Furukawa, Y., Ikegami, R., Nakamura, N., Omae, F., Hashimoto, Y., Hayashi, K. and Furukawa, S. (1993) Pharmacological induction of physiologically active nerve growth factor in rat peripheral nervous system. J. Pharmacol. Exp. Ther. 264, 321-326.
72. Kaisho, Y., Yoshimura, K. and Nakahama, K. (1990) Cloning and expression of a cDNA encoding a novel human neurotrophic factor. FEBS Lett. 266, 187-191.
73. Kaplan, D.R., Hempstead, B.L., Martin-Zanca, D., Chao, M. V., Parada, L. F. (1991a) The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science 252, 554-558.
74. Kaplan, D.R., Martin-Zanca, D., Parada, L.F. (1991b) Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF. Nature 350, 158-160.
75. Katoh-Semba, R., Facci, L., Skaper, S. D. and Varon, S. (1986) Gangliosides stimulate astroglial cell proliferation in the absence of serum. J. Cell Physiol. 126, 147-153.
76. Klein, R., Jing, S., Nanduri, V., O'Rourke, E. and Barbacid, M. (1991) The trk proto-oncogene encodes a receptor for nerve growth factor. Cell. 65, 189-197.
77. Knusel, B., Winslow, J. W., Rosenthal, A., Burton, L. E., Seid, D. P., Nikolics, K. and Hefti, F. (1991) Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3. Proc. Natl. Acad. Sci. USA. 88, 961-965.
78. Korsching, S. and Thoenen, H. (1983) Quantitative demonstration of retrograde axonal transport of endogenous nerve growth factor. Neurosci. Lett. 39, 1-4.
79. Kristensson, K. and Olsson, Y. (1975) Retrograde transport of horseradish peroxidase in transected axons. II. Relations between rate of transfer from the site of injury to the perikaryon and onset of chromatolysis. J. Neurocytol. 4, 653-661.
80. Landreth, G. E. and Shooter, E. M. (1980) Nerve growth factor receptors on PC12 cells: ligand-induced conversion from low-to high-affinity states. Proc. Natl. Acad. Sci. U.S.A. 77, 4751-4755.
81. Leibrock, J., Lottspeich, F., Hohn, A., Hofer, M., Hengerer, B., Masiakowski, P., Thoenen, H. and Barde, Y. A. (1989) Molecular cloning and expression of brain-derived neurotrophic factor. Nature. 341, 149-152.
82. Levi-Montalcini, R. and Angelelti, P. (1968). Nerve growth factor. Physiol. Rev. 48, 534-569.
83. Lindenbaum, M. H., Carbonetto, S. T., Grosveld, F., Flavell, D. and Mushynski, W. E. (1988) Transcriptional and post-transcriptional effects of nerve growth factor on expression of the three neurofilament subunits in PC-12 cells. J. Biol. Chem. 263, 5662-5667.
84. Lindholm, D., Hengerer, B., Zafra, F. and Thoenen, H. (1990) Transforming growth factor-beta 1 stimulates expression of nerve growth factor in the rat CNS. Neuroreport. 1, 9-12.
85. Lindholm, D., Heumann, R., Hengerer, B. and Thoenen, H. (1988) Interleukin 1 increases stability and transcription of mRNA encoding nerve growth factor in cultured rat fibroblasts. J. Biol. Chem. 263, 16348-16351.
86. Lindholm, D., Heumann, R., Meyer, M. and Thoenen, H. (1987) Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve. Nature. 330, 658.
87. Longo, A. M. and Penhoet, E. E. (1974) Nerve growth factor in rat glioma cells. Proc. Natl. Acad. Sci. U.S.A. 71, 2347-2349.
88. Maisonpierre, P.C., Belluscio, L., Friedman, B., Alderson, R.F., Wiegand, S.J., Furth, M.E., Lindsay, R.M. and Yancopoulos, G.D. (1990a) NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression. Neuron 5, 501-509.
89. Maisonpierre, P.C., Belluscio, L., Squinto, S., Ip, N.Y., Furth, M.E., Lindsay, R.M. and Yancopoulos, G.D. (1990b) Neurotrophin-3: a neurotrophic factor related to NGF and BDNF. Science 247, 1446-1451.
90. Maisonpierre, P. C., Le-Beau, M. M., Espinosa, R., Ip, N. Y., Belluscio, L., de-la-Monte, S. M., Squinto, S., Furth, M. E. and Yancopoulos, G. D. (1991) Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. Genomics. 10, 558-568.
91. Martin-Zanca, D., Barbacid, M. and Parada, L. F. (1990) Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development. Genes Dev. 4, 683-694.
92. Martin-Zanca, D., Hughes, S. H. and Barbacid, M. (1986) A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature. 319, 743-748.
93. Matsuoka, I., Meyer, M. and Thoenen, H. (1991) Cell-type-specific regulation of nerve growth factor (NGF) synthesis in non-neuronal cells: comparison of Schwann cells with other cell types. J. Neurosci. 11, 3165-3177.
94. Mayer, J. H. and Tomlinson, D. R. (1983) Axonal transport of cholinergic transmitter enzymes in vagus and sciatic nerves of rats with acute experimental diabetes mellitus; correlation with motor nerve conduction velocity and effects of insulin. Neuroscience. 9, 951-957.
95. McDonald, N. Q., Lapatto, R., Murray-Rust, J., Gunning, J., Wlodawer, A. and Blundell, T. L. (1991) New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor. Nature. 354, 411-414.
96. Meakin, S. O. and Shooter, E. M. (1991) Tyrosine kinase activity coupled to the high-affinity nerve growth factor-receptor complex. Proc. Natl. Acad. Sci. USA. 88, 5862-5866.
97. Medori, R., Autilio-Gambetti, L., Jenich, H. and Gambetti, P. (1988) Changes in axon size and slow axonal transport are related in experimental diabetic neuropathy. Neurology. 38, 597-601.
98. Medori, R., Autilio-Gambetti, L., Monaco, S. and Gambetti, P. (1985) Experimental diabetic neuropathy: impairment of slow transport with changes in axon cross-sectional area. Proc. Natl. Acad. Sci. USA. 82, 7716-7720.
99. Meier, R., Becker-Andre, M., Gotz, R., Heumann, R., Shaw, A. and Thoenen, H. (1986) Molecular cloning of bovine and chick nerve growth factor (NGF): delineation of conserved and unconserved domains and their relationship to the biological activity and antigenicity of NGF. EMBO J. 5, 1489-1493.
100. Middlemas, D. S., Lindberg, R. A. and Hunter, T. (1991) trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors. Mol. Cell Biol. 11, 143-153.
101. Mocchetti, I., De Bernardi, M. A., Szekely, A. M., Alho, H., Brooker, G. and Costa, E. (1989) Regulation of nerve growth factor biosynthesis by β-adrenergic receptor activation in astrocytoma cells: A potential role of c-Fos protein. Proc. Natl. Acad. Sci. USA. 86, 3891-3895.
102. Mocchetti, I., Toso, D., Yakovlev, A. G. et al., (1990) Regulation of nerve growth factor gene expression in vitro and in vivo studies. In: Trophic factors and the nervous system. pp. 85-94. Eds. Horrocks LA. Neff NH, and Yates AJ. Raven Press: New York.
103. Montminy, M. R., Sevarino, K. A., Wagner, J. A., Mandel, G. and Goodman, R. H. (1986) Identification of a cyclic-AMP-responsive element within the rat somatostatin gene. Proc. Natl. Acad. Sci. U.S.A. 83, 6682-6686.
104. Morbin, M., Monaco, S., Zanette, G. and Rizzuto, N. (1993) IDPN impairs post-traumatic regeneration of rat sciatic nerve. Neuropathol. Appl. Neurobiol. 19, 489-499.
105. Murase, K., Hattori, A., Kohno, M. and Hayashi, K. (1993) Stimulation of nerve growth factor synthesis/secretion in mouse astroglial cells by coenzymes. Biochem. Mol. Biol. Int. 30, 615-621.
106. Nabeshima, T., Nitta, A., Fuji, K., Kameyama, T. and Hasegawa, T. (1994) Oral administration of NGF synthesis stimulators recovers reduced brain NGF content in aged rats and cognitive dysfunction in basal-forebrain-lesioned rats. Gerontology. 40 Suppl. 2, 46-56.
107. Nebreda, A. R., Martin-Zanca, D., Kaplan, D. R., Parada, L. F. and Santos, E. (1991) Induction by NGF of meiotic maturation of Xenopus oocytes expressing the trk proto-oncogene product. Science. 252, 558-561.
108. Neveu, I., Jehan, F., Houlgatte, R., Wion, D. and Brachet, P. (1992) Activation of nerve growth factor synthesis in primary glial cells by phorbol 12-myristate 13-acetate: Role of protein kinase C. Brain Res. 570, 316-322.
109. Nitta, A., Hasegawa, T. and Nabeshima, T. (1993) Oral administration of idebenone, a stimulator of NGF synthesis, recovers reduced NGF content in aged rat brain. Neurosci. Lett. 163, 219-222.
110. Nitta, A., Murakami, Y., Furukawa, Y., Kawatsura, W., Hayashi, K., Yamada, K., Hasegawa, T. and Nabeshima, T. (1994) Oral administration of idebenone induces nerve growth factor in the brain and improves learning and memory in basal forebrain-lesioned rats. Naunyn Schmiedebergs Arch. Pharmacol. 349, 401-407.
111. Ochs, S. (1987) The action of neurotoxins in relation to axoplasmic transport. Neurotoxicol. 8, 155-166.
112. Ohi, T., Furukawa, S., Hayashi, K. and Matsukura, S. (1990) Ganglioside stimulation of nerve growth factor synthesis in cultured rat Schwann cells. Biochem. Int. 20, 739-746.
113. Ohnishi, A. and Ikeda, M. (1980) Morphometric evaluation of primary sensory neurons in experimental p-bromophenylacetylurea intoxication. Acta Neuropathol. (Berl). 52, 111-118.
114. Ordway, G. A., O'Donnell, J. M. and Frazer, A. (1987) Effects of clenbuterol on central beta-1 and beta-2 adrenergic receptors of the rat. J. Pharmacol. Exp. Ther. 241, 187-195.
115. Powell, H. C., Costello, M. L. and Myers, R. R. (1981) Endoneurial fluid pressure in experimental models of diabetic neuropathy. J. Neuropathol. Exp. Neurol. 40, 613-624.
116. Prineas, J. (1969) The pathogenesis of dying-back polyneuropathies. II. An ultrastructural study of experimental acrylamide intoxication in the cat. J. Neuropathol. Exp. Neurol. 28, 598-621.
117. Pshenichkin, S. P. and Wise, B. C. (1995) Okadaic acid increases nerve growth factor secretion, mRNA stability, and gene transcription in primary cultures of cortical astrocytes. J. Biol. Chem. 270, 5994-5999.
118. Radeke, M. J., Misko, T. P., Hsu, C., Herzenberg, L. A. and Shooter, E. M. (1987) Gene transfer and molecular cloning of the rat nerve growth factor receptor. Nature. 325, 593-597.
119. Raivich, G., Zimmermann, A. and Sutler, A. (1985) The spatial and temporal pattern of beta NGF receptor expression in the developing chick embryo. EMBO J. 4, 637-644.
120. Reinhold, D. S. and Neet, K. E. (1989) The lack of a role for protein kinase C in neurite extension and in the induction of ornithine decarboxylase by nerve growth factor in PC12 cells. J. Biol. Chem. 264, 3538-3544.
121. Richardson, P. M., Verge Issa, V. M. K. and Riopelle, R. J. (1986) Distribution of neuronal receptors for nerve growth factor in the rat. J. Neurosci. 6, 2312-2321.
122. Rosenthal, A., Goeddel, D. V., Nguyen, T., Lewis, M., Shih, A., Laramee, G. R., Nikolics, K. and Winslow, J. W. (1990) Primary structure and biological activity of a novel human neurotrophic factor. Neuron. 4, 767-773.
123. Rush, R. A. (1984) Immunohistochemical localization of endogenous nerve growth factor. Nature. 312, 364-376.
124. Sahenk, Z. and Mendell, J. R. (1979) Ultrastructural study of zinc pyridinethione-induced peripheral neuropathy. J. Neuropathol. Exp. Neurol. 38, 532-550.
125. Sahenk, Z. and Mendell, J. R. (1980) Axoplasmic transport in zinc pyridinethione neuropathy: evidence for an abnormality in distal turn-around. Brain Res. 186, 343-353.
126. Sahenk, Z. and Mendell, J. R. (1981) Acrylamide and 2.5-hexanedione neuropathies: abnormal bidirectional transport rate in distal axons. Brain Res. 219, 397-405.
127. 3-mediated induction of nerve growth factor mRNA and protein in L929 fibroblasts and in adult rat brain. Brain Res. 633, 189-196.
128. Saporito, M. S., Wilcox, H. M., Hartpence, K. C., Lewis, M. E., Vaught, J. L. and Carswell, S. (1993) Pharmacological induction of nerve growth factor mRNA in adult rat brain. Exp. Neurol. 123, 295-302.
129. Schlechter, A. L. and Bothwell, M. A. (1981) Nerve growth factor receptors on PC12 cells: evidence for two receptor classes with differing cytoskeletal association. Cell. 24, 867-874.
130. Schneider, R. and Schweiger, M. (1991) A novel modular mosaic of cell adhesion motifs in the extracellular domains of the neurogenic trk and trkB tyrosine kinase receptors. Oncogene. 6, 1807-1811.
131. Schreck, R., Rieber, P. and Baeuerle, P. A. (1991) Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-B transcription factor and HIV-1. EMBO J. 10, 2247-2258.
132. Schwartz, J. P. (1988) Stimulation of nerve growth factor mRNA content in C6 glioma cells by a beta-adrenergic receptor and by cyclic AMP. GLIA. 1, 282-285.
133. Schwartz, J. P. and Costa, E. (1977) Regulation of nerve growth factor content in C6 glioma cells by beta-adrenergic receptor stimulation. Naunyn Schmiedebergs Arch. Pharmacol. 300, 123-129.
134. Schwartz, J. P. and Mishler, K. (1990) Beta-adrenergic receptor regulation, through cyclic AMP, of nerve growth factor expression in rat cortical and cerebellar astrocytes. Cell Mol. Neurobiol. 10, 447-457.
135. Scott, J., Selby, M., Urdea, M., Quiroga, M., Bell, G. J. and Rutter, W. J. (1983) Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor. Nature. 302, 538-540.
136. Selby, M. J., Edwards, R., Sharp, F. and Rutter, W. J. (1987) Mouse nerve growth factor gene: structure and expression. Mol. Cell Biol. 7, 3057-3063.
137. Sharma, A. K., Bajada, S. and Thomas, P. K. (1981) Influence of streptozotocin-induced diabetes on myelinated nerve fiber maturation and on body growth in the rat. Acta Neuropathol. 53, 257-265.
138. Sharma, A. K., Thomas, P. K. and Baker, R. W. R. (1976) Peripheral nerve abnormalities related to galactose administration in rats. J. Neurol. Neurosurg. Psych. 39, 794-802.
139. Shelton, D. L. and Reichardt, L. F. (1984) Expression of the beta nerve growth factor gene correlates with the density of sympathetic innervation in effector organs. Proc. Natl. Acad. Sci. USA. 81, 7951-7955.
140. Shinoda, I., Furukawa, Y. and Furukawa, S. (1990) Stimulation of nerve growth factor synthesis/secretion by propentofylline in cultured mouse astroglial cells. Biochem. Pharmacol. 39, 1813-1819.
141. Sidenius, P. (1986) The effect of doxorubicin on slow and fast components of the axonal transport system in rats. Brain. 109, 885-896.
142. Sidenius, P. and Jakobsen, J. (1979) Axonal transport in early experimental diabetes. Brain Res. 173, 315-330.
143. Sidenius, P. and Jakobsen, J. (1980) Axonal transport in rats after galactose feeding. Diabetologia. 19, 229-233.
144. Sidenius, P. and Jakobsen, J. (1982) Reversibility and preventability of the decrease in slow axonal transport velocity in experimental diabetes. Diabetes. 31, 689-693.
145. Sidenius, P. and Jakobsen, J. (1983) Peripheral neuropathy in rats induced by insulin treatment. Diabetes. 32, 383-386.
146. Smith, C. A., Davis, T., Anderson, D., Solam, L., Beckmann, M. P., Jerzy, R., Dower, S. K., Cosman, D. and Goodwin, R. G. (1990) A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins. Science. 248, 1019-1023.
147. Soppet, D., Escandon, E., Maragos, J., Middlemas, D. S., Reid, S. W., Blair, J., Burton, L. E., Stanton, B. R., Kaplan, D. R. and Hunter, T. et al. (1991) The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. Cell. 65, 895-903.
148. Spranger, M., Lindholm, D., Brandtlow, C., Heumann, R., Gnahn, H., Naher-Noe, N. and Thoenen, H. (1990) Regulation of nerve growth factor (NGF) synthesis in the rat central nervous system: comparison between effects of interleukin I and various growth factors in astrocyte cultures and in vivo. Eur. J. Neurosci. 2, 63-66.
149. Takeuchi, R., Murase, K., Furukawa, Y., Furukawa, S. and Hayashi, K. (1990) Stimulation of nerve growth factor synthesis/secretion by 1,4-benzoquinone and its derivatives in cultured mouse astroglial cells. FEBS Lett. 261, 63-66.
150. Tomlinson, D. R., Moriarty, R. J. and Mayer, J. H. (1984) Prevention and reversal of defective axonal transport and motor nerve conduction velocity in rats with experimental diabetes by treatment with the aldose reductase inhibitor Sorbinil. Diabetes. 33, 470-476.
151. Toso, R. D., De Bernardi, M. A., Brooker, G., Costa, E. and Mocchetti, I. (1988) Beta adrenergic and prostaglandin receptor activation increases nerve growth factor mRNA content in C6-2B rat astrocytoma cells. J. Pharm. Exp. Ther. 246, 1190-1193.
152. Toso, R. D., De Bernardi, M. A., Costa, E. and Mocchetti, I. (1987) Beta-adrenergic receptor regulation of NGF-mRNA content in rat C6-2B glioma cells. Neuropharmacology. 26, 1783-1786.
153. Ullrich, A., Gray, A., Berman, C. and Dull, T. J. (1983) Human β-nerve growth factor gene sequence highly homologous to that of mouse. Nature. 303, 821-825.
154. Unsicker, K., Krisch, B., Otten, U. and Thoenen, H. (1978) Nerve growth factor-induced fiber outgrowth from isolated rat adrenal chromaffin cells: impairment by glucocorticoids. Proc. Natl. Acad. Sci. U.S.A. 75, 3498-3502.
155. Vitadello, M., Filliatreau, G., Dupont, J. L., Hassig, R., Gorio, A. and Giamberardino, L. (1985) Altered axonal transport of cytoskeletal proteins in the mutant diabetic mouse. J. Neurochem. 45, 860-868.
156. Weskamp, G. and Reichardt, L. F. (1991) Evidence that biological activity of NGF is mediated through a novel subclass of high affinity receptors. Neuron. 6, 649-663.
157. Westermann, R., Hardung, M., Meyer, D. K., Ehrhard, P., Otten, U. and Unsicker, K. (1988) Neuronotrophic factors released by C6 glioma cells. J. Neurochem. 50, 1747-1758.
158. White, M. F. (1991) Structure and function of tyrosine kinase receptors. [Review]. J. Bioenerg. Biomembr. 23, 63-82.
159. Whittemore, S. R., Friedman, P. L., Larhammar, D., Persson, H., Gonzalez-Carvajal, M. and Holets, V. R. (1988) Rat beta-nerve growth factor sequence and site of synthesis in the adult hippocampus. J. Neurosci. Res. 20, 403-410.
160. Willard, M. B. and Hulebak, K. L. (1977) The intra-axonal transport of polypeptide H: evidence for a fifth (very slow) group of transported proteins in the retinal ganglion cells of the rabbit. Brain Res. 136, 289-306.
161. Willars, G. B., Tomlinson, D. R. and Robinson, J. P. (1986) Studies of sorbinil on axonal transport in streptozotocin-diabetic rats. Metabolism. 35, 66-70.
162. Wion, D., Barrand, P., Dicou, E., Scott, J. and Brachet, P. (1985) Serum and thyroid hormones T3 and T4 regulate nerve growth factor mRNA levels in mouse L cells. FEBS Lett. 189, 37-41.
163. Wion, D., Mac Grogan, D., Houlgatte, R. and Brachet, P. (1990) Phorbol 12-myristate 13-acetate (PMA) increases the expression of the nerve growth factor (NGF) gene in mouse L-929 fibroblasts. FEBS Lett. 262, 42-44.
164. 3 is a potent inducer of nerve growth factor synthesis. J. Neurosci. Res. 28, 110-114.
165. Woodruff, N. R. and Neet, K. E. (1986) Beta nerve growth factor binding to PC12 cells. Association kinetics and cooperative interactions. Biochemistry. 25, 7956-7966.
166. Yamaguchi, K., Sasano, A., Urakami, T., Tsuji, T. and Kondo, K. (1993a) Stimulation of nerve growth factor production by pyrroloquinoline quinone and its derivatives in vitro and in vivo. Biosci. Biotechnol. Biochem. 57, 1231-1233.
167. Yamaguchi, K., Tsuji, T., Wakuri, S., Yazawa, K., Kondo, K., Shigemori, H. and Kobayashi, J. (1993b) Stimulation of nerve growth factor synthesis and secretion by fellutamide A in vitro. Biosci. Biotechnol. Biochem. 57, 195-199.
168. Yamaguchi, K., Uemura, D., Tsuji, T. and Kondo, K. (1994) Stimulation of nerve growth factor production by diterpenoids isolated from plants of Euphorbia species. Biosci. Biotechnol. Biochem. 58, 1749-1751.
169. Yan, Q. and Johnson, E. M. (1988) An immunohistochemical study of the nerve growth factor receptor in developing rats. J. Neurosci. 8, 3481-3498.
170. Yoshida, K. and Gage, F. H. (1991) Fibroblast growth factors stimulate nerve growth factor synthesis and secretion by astrocytes. Brain Res. 538, 118-126.
171. Yoshida, K. and Gage, F. H. (1992) Cooperative regulation of nerve growth factor synthesis and secretion in fibroblasts and astrocytes by fibroblast growth factor and other cytokines. Brain Res. 569, 14-25.