Activation of the contact and fibrinolytic systems after intravenous administration of endotoxin to normal human volunteers: Correlation with the cytokine profile

Immunopharmacology

Volumn 33, Issue 1-3, 1996, Pages 231-237

  DeLa Cadena, Raul A ^a   Majluf Cruz, Abraham ^a   Stadnicki, Antoni ^a   Agosti, Jan M ^b   Colman, Robert W ^a   Suffredini, Anthony F ^c  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b AMGEN INC   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

cytokines; endotoxin; fibrinolysis; kallikrein kinin system

Indexed keywords

CYTOKINE; ENDOTOXIN;

BLOOD CLOTTING; CONFERENCE PAPER; FIBRINOLYSIS; HUMAN; INFLAMMATION; KALLIKREIN KININ SYSTEM; MULTIPLE ORGAN FAILURE; NORMAL HUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REGULATORY MECHANISM; SEPSIS; VOLUNTEER;

EID: 0030175321     PISSN: 01623109     EISSN: None     Source Type: Journal    
DOI: 10.1016/0162-3109(96)00064-1     Document Type: Conference Paper

References (30)

1. Bevilacqua MP, Pober JS, Wheeler ME, Mendrik D, Cotran RS, Gimbron MA Jr. Interleukin-1 acts on cultured human vascular endothelial cells to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines. J Clin Invest 1985; 76: 2003-2011.
2. Brower MS, Harpel PC. Alpha-1-antitrypsin-human leukocyte clastase complexes in blood: quantification by an enzyme-linked differential antibody immunosorbent assay and comparison with alpha-2-plasmin inhibitor-plasmin complexes. Blood 1983; 61: 842-849.
3. Colman RW, Flores DN, DeLa Cadena RA, Scott CF, Cousens L, Barr PJ, Hoffman IB, Kueppers F, Fisher D, Idell S, Pisarello J. Recombinant alpha-1-antritrypsin Pittsburgh attenuates experimental gram negative septicemia. Am J Pathol 1988; 130: 418-426.
4. Danner RL, Elin RJ, Hosseini JM, Wesley RA, Reilly JM, Parrillo JE. Endotoxemia in human septic shock Chest 1991; 99: 169-175.
5. DeLa Cadena R, Suffredini AF, Page JD, Pixley RA, Kaufman N, Parrillo J, Colman RW. Activation of the kallikrein-kinin system after endotoxin administration to normal human volunteers. Blood 1993; 81: 3313-3317.
6. DeLa Cadena RA, Miller M, Stadnicki A, Tropea M, Agosti J, Colman RW, Suffredini AF. Recombinant tumor necrosis factor receptor (TNFR:Fc) alters endotoxin-induced activation of the contact and fibrinolytic systems in human volunteers. Blood 1994a; 84: 189a.
7. DeLa Cadena RA, Watchfogel Y, Colman RW. Contact activation pathway: Inflammation and coagulation. In: Colman RW, Hirsh J, Marder V, Salzman EW, Eds. Hemostasis and Thrombosis: Basic Principles and Clinical Practice. Philadelphia: Lippincott Co., 1994b: 219-240.
8. Dinarello CA. Interleukin-1. Dig Dis Sci 1988; 33: 25S-35S.
9. Dinarello CA, Cannon JG. Cytokine measurements in septic shock. Ann Intern Med 1993; 119: 853-854.
10. Gallimore MJ, Aasen AO, Lyngaas KHN, Larsbraaten M, M, Amundsen E. Falls in plasma levels of prekallikrein, high molecular weight kininogen, and kallikrein inhibitors during lethal endotoxin shock in dogs. Thromb Res 1978; 12: 307-318.
11. Gershenwald JE, Fong YM, Fahey TJ, Calvano SE, Chizzonite R, Kilian PL, Lowry SF, Moldawer LL. Interleukin 1 receptor blockade attenuates the host inflammatory response. Proc Natl Acad Sci USA 1990; 87: 4966-4970.
12. Goldsmith G, Saito H Jr, Ratnoff OD. The activation of plasminogen by Hageman XII (factor XII), and Hageman factor fragments. J Clin Invest 1978; 62: 54-60.
13. Hekman CM, Loskutoff DL. Fibrinolytic pathways and the endothelium. Semin Thromb Hemost 1987; 13: 514-427.
14. Kimball HR, Melmon KL, Wolff SM. Endotoxin-induced kinin production in man. Proc Soc Exp Biol Med 1972; 139: 1078-1083.
15. Martich GD, Boujoukos AJ, Suffredini AF. Response of man to endotoxin. Immunobiol 1993; 187: 403-416.
16. McGovern VJ. Shock revisited. Pathol Annu 1984;19:15-36.
17. Michie HR., Manogue KR, Spriggs DR, Revhaug A, O'Dwyer S, Dinarello CA, Cerami A, Wolff SM, Wilmore DW. Detection of circulating tumor necrosis factor after endotoxin administration. N Engl J Med 1988; 318: 1481-1486.
18. Morrison DC, Ryan JL: Endotoxins and disease mechanisms. Annu Rev Med 1987; 38: 417-432.
19. Naehman RL, Hajjar KA, Silverstein RL, Dinarello CA. Interleukin-1 induces endothelial cells synthesis of plasminogen activator inhibitor. J Exp Med 1986; 163: 1545-1547.
20. Parrillo JE, moderator. Septic Shock in humans: Advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy. Ann Intern Med 1990; 113: 227-242.
21. Parrillo JE. Pathogenetic mechanisms of septic shock. N Engl J Med 1995; 328: 1471-1477.
22. Pixley RA, DeLa Cadena RA, Page JD, Kaufman N, Wyshock EG, Chang A, Taylor FB Jr, Colman RW. The contact system contributes to hypotension but not disseminated intravascular coagulation in lethal bacteremia: In vivo use of a monoclonal anti-factor XI antibody to block the contact activation of baboons. J Clin Invest 1993; 91: 61-68.
23. Raetz CRH, Ulevitch RJ, Wright SD, Sibley CH, Ding A, Nathan CF. Gram-negative endotoxin: An extraordinary lipid with profound effects on eukaryotic signal transduction. FASEB J 1991; 5: 2652-2660.
24. Sprengers ED, Kluft C. Plasminogen activator inhibitors. Blood 1987; 69: 381-387.
25. Stern DM, Bank I, Nawroth PP, Cassimeris J, Kisiel W, Fenton JW, Dinarello C, Chess L, Jaffe EA. Self-regulation of procoagulant events on the endothelial cell surface. J Exp Med 1985; 162: 1223-1235.
26. Suffredini AF, Fromm RE, Parker MM, Brenner M, Kovacs JA, Wesley RA, Parrillo JE: The cardiovascular response of normal humans to the administration of endotoxin. N Engl J Med 1989; 321: 280-287.
27. Suffredini AF, Harpel PC, Parrillo JE. Promotion and subsequent inhibition of plasminogen activator after administration of intravenous endotoxin to normal subjects. N Engl J Med 1990; 320: 1165-1172.
28. Suffredini AF, Reda D, Banks SM, Tropea M, Agosti JM, Miller R. Effects of recombinant dimeric tumor necrosis factor receptor on human inflammatory responses following intravenous endotoxin administration. J Immunol 1995; 155: 5038-5045.
29. van Deventer SJH, Buller HR, ten Cate JW, Aarden LA, Hack CE, Sturk A. Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways. Blood 1990; 76: 2520-2526.
30. Ziegler EJ, McCutchan JA, Fierer J, Glanser MP, Sadoff JC, Douglas H, Braude AI. Treatment of gram-negative bacteremia and shock with human antiserum to a mutant Escherichia coli. N Engl J Med 1982; 307: 1225-1230.