Protein kinase C activator inhibits progression of osteoarthritis induced in rabbit knee joints

Journal of Laboratory and Clinical Medicine

Volumn 127, Issue 6, 1996, Pages 540-544

  Hamanishi, Chiaki ^a   Hashima, Makoto ^a   Satsuma, Hiroshi ^a   Tanaka, Seisuke ^a  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0030174861     PISSN: 00222143     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2143(96)90144-4     Document Type: Article

References (13)

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3. Arner EC, Pratta MA. Modulation of interleukin-1-induced alterations in cartilage proteoglycan metabolism by activation of protein kinase C. Arthritis Rheum 1991;34:1006-13.
4. Yoshimi T, Kikuchi T, Obara T, et al. Effects of high-molecular-weight sodium hyaluronate on experimental osteoarthrosis induced by the resection of rabbit anterior cruciate ligament. Clin Ortho Rel Res 1994;298:296-304.
5. Mankin HJ, Dorfman H, Lippiello L, Zarins A. Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg 1971;53-A:523-37.
6. Hulth A, Lindberg L, Telhag H. Experimental osteoarthritis in rabbits. Acta Orthop Scand 1970;41:522-30.
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9. Myers SL, Brandt KD, O'Conner BL, Visco DM, Albrecht ME. Synovitis and osteoarthritic changes in canine articular cartilage after anterior cruciate ligament transection: effect of surgical hemostasis. Arthritis Rheum 1990;33:1406-15.
10. Kimura T, Hujioka H, Matsubara T, Itoh T. The role of protein kinase C in glycosaminoglycan synthesis by cultured bovine articular chondrocytes [in Japanese]. Clin Rheumatol 1994;5:240-6.
11. Satsuma H, Saitou N, Hamanishi C, Hashima M, Tanaka S. Alpha and epsilon isozymes of protein kinase C in the chondrocytes in normal and early osteoarthritic articular cartilage. Calcif Tiss Int (in press).
12. Mochly-Rosen D. Localization of protein kinase by anchoring proteins: a theme in signal transduction. Science 1995; 268:247-51.
13. Papadopoulos V, Hall P. Isolation and characterization of protein kinase c from Y-1 adrenal cell cytoskeleton. J Cell Biol 1989;108:553-67.