Ca2+ Sensitization in Idiopathic Dilated Human Myocardium: Differential in vitro effects of (+)-(5-methyl-6-phenyl)-1,3,5,6-tetrahydro-3,6-methano-1,5-benzodiazocine-2,4- dione, a novel purely Ca2+sensitizing agent

Arzneimittel-Forschung/Drug Research

Volumn 46, Issue 6, 1996, Pages 586-593

  Herzig, Joachim W ^a,c   Chiesi, Michele ^a   Depersin, Heidrun ^a   Grüninger, Stephan ^a   Hasenfuss, Gerd ^b   Kubalek, Ralf ^b   Leutert, Thomas ^a   Pieske, Burkert ^b   Pioch, Katja ^b   Wenk, Paul ^a   Holubarsch, Christian ^b  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b UNIVERSITY OF FREIBURG   (Germany)

^c AGA KHAN UNIVERSITY   (Pakistan)

Author keywords

5 (1 (3,4 Dimethoxybenzoyl) 1,2,3,4 tetrahydroquinolin 6 yl) 6 methyl 3,6 dihydro 2H 1,3,4 thiadiazin 2 one; CAS 105755 40 8; CAS 120223 04 3; CAS 147527 31 9; CGP 48506, positive inotropic effect; EMD 53998, (+) enantiomer

Indexed keywords

1,3,5,6 TETRAHYDRO 5 METHYL 6 PHENYL 3,6 METHANO 1,5 BENZODIAZOCINE 2,4 DIONE; 5 [1 (3,4 DIMETHOXYBENZOYL) 1,2,3,4 TETRAHYDRO 6 QUINOLYL] 3,6 DIHYDRO 6 METHYL 2H 1,3,4 THIADIAZIN 2 ONE; BENZODIAZOCINE DERIVATIVE; CALCIUM; CALCIUM SENSITIZER; PHOSPHODIESTERASE III INHIBITOR; PHOSPHODIESTERASE INHIBITOR; THIADIAZINONE DERIVATIVE; UNCLASSIFIED DRUG; ANILINE DERIVATIVE; AZOCINE DERIVATIVE; BA 41899; CARDIOTONIC AGENT; DIAGNOSTIC AGENT; FLUO 3; QUINOLINE DERIVATIVE; THIADIAZINE DERIVATIVE; XANTHENE DERIVATIVE;

ANIMAL CELL; ARTICLE; CARDIOMYOPATHY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENANTIOMER; HEART DILATATION; HEART MUSCLE CONTRACTILITY; HUMAN; HUMAN TISSUE; IDIOPATHIC DISEASE; INOTROPISM; NONHUMAN; SKINNED MUSCLE FIBER; CONGESTIVE CARDIOMYOPATHY; DRUG EFFECT; ELECTROSTIMULATION; HEART CONTRACTION; HEART MUSCLE; IN VITRO STUDY; METABOLISM; PATHOLOGY; PHYSIOLOGY; STIMULATION;

ANILINE COMPOUNDS; AZOCINES; CALCIUM; CARDIOMYOPATHY, DILATED; CARDIOTONIC AGENTS; ELECTRIC STIMULATION; HUMANS; MYOCARDIAL CONTRACTION; MYOCARDIUM; PHOSPHODIESTERASE INHIBITORS; QUINOLINES; STIMULATION, CHEMICAL; THIADIAZINES; XANTHENES;

EID: 0030170851     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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