Glutamic acid decarboxylase message isoforms in human suprachiasmatic nucleus

Journal of Biological Rhythms

Volumn 11, Issue 2, 1996, Pages 172-179

  Gao, Bo ^a,b   Moore, Robert Y ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Alzheimer's disease; Circadian system; GABA; GAD65; GAD67; In situ hybridization; Paraventricular nucleus

Indexed keywords

RODENTIA;

4 AMINOBUTYRIC ACID; GLUTAMATE DECARBOXYLASE; ISOENZYME; MESSENGER RNA;

ANIMAL; ANTIBODY SPECIFICITY; ARTICLE; BIOSYNTHESIS; CYTOLOGY; ENZYMOLOGY; GENETIC TRANSCRIPTION; HUMAN; HYPOTHALAMUS; IN SITU HYBRIDIZATION; NERVE CELL; OLIGONUCLEOTIDE PROBE; RAT; RODENT; SENSITIVITY AND SPECIFICITY; SUPRACHIASMATIC NUCLEUS;

ANIMALS; GAMMA-AMINOBUTYRIC ACID; GLUTAMATE DECARBOXYLASE; HUMANS; HYPOTHALAMUS; IN SITU HYBRIDIZATION; ISOENZYMES; NEURONS; OLIGONUCLEOTIDE PROBES; ORGAN SPECIFICITY; RATS; RNA, MESSENGER; RODENTIA; SENSITIVITY AND SPECIFICITY; SUPRACHIASMATIC NUCLEUS; TRANSCRIPTION, GENETIC;

EID: 0030160172     PISSN: 07487304     EISSN: None     Source Type: Journal    
DOI: 10.1177/074873049601100209     Document Type: Article

References (22)

1. Braak H and Braak E (1987) The hypothalamus of the human adult: Chiasmatic region. Anat Embryol 176:315-330.
2. Bu DF, Erlander MG, Hitz BC, Tillakaratne N, Kaufman DL, Wagner-McPherson CB, Evans GA, and Tobin AJ (1992) Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene. Proc Natl Acad Sci 89:2115-2119.
3. Erlander MG, Niranjala JK, Tillakaratne N, Feldblum S, Patel N, and Tobin AJ (1991) Two genes encode distinct glutamate decarboxylases. Neuron 7:91-100.
4. Esclapez M, Tillakaratne N, Kaufman DL, Tobin AJ, and Houser CR (1994) Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms. J Neurosci 14:1834-1855.
5. Esclapez M, Tillakaratne N, Tobin AJ, and Houser CR (1993) Comparative localization of mRNAs encoding two forms of glutamic acid decarboxylase with nonradioactive in situ hybridization methods. J Comp Neurol 331:339-362.
6. 67 mRNAs suggest that the two glutamate decarboxylases play distinctive functional roles. J Neurosci Res 34:689-706.
7. Goudsmit E, Hofman MA, Fliers E, and Swaab DF (1990) The supraoptic and paraventricular nuclei of the human hypothalamus in relation to sex, age and Alzheimer's disease. Neurobiol Aging 11:529-536.
8. 67) in adult monkey visual cortex. J Comp Neurol 343:566-581.
9. Lucassen PJ, Goudsmit E, Pool CW, Mengod G, Palacios JM, Raadsheer RC, Guldenaar SEF, and Swaab DF (1995) In situ hybridization of vasopressin mRNA in the human supraoptic and paraventricular nucleus; quantitative aspects of formalin-fixed paraffin-embedded tissue sections as compared to cryostat sections. J Neurosci Methods 57:221-230.
10. Mai JK, Kedziora O, Teckhaus L, and Sofroniew MV (1991) Evidence for subdivisions in the human suprachiasmatic nucleus. J Comp Neurol 305:508-525.
11. Mai JK, Triepel J, and Metz J (1987) Neurotensin in the human brain. Neuroscience 22:499-524.
12. Moore RY (1989) The geniculohypothalamic tract in monkey and man. Brain Res 486:190-194.
13. Moore RY (1992) The organization of the human circadian timing system. Prog Brain Res 93:101-117.
14. Moore RY (in press) Entrainment pathways and the functional organization of the circadian system. Prog Brain Res.
15. Moore RY and Speh JC (1993) GABA is the principal neurotransmitter of the circadian system. Neurosci Lett 150:112-116.
16. Moore RY, Speh JC, and Suhan N (1994) The suprachiasmatic nucleus in Alzheimer's disease. Soc Neurosci Abstr 20:158.
17. Okamura H, Berod A, Julien J, Geffard M, Kitahama K, Mallet J, and Bobilier P (1989) Demonstration of GABA-ergic cell bodies in the suprachiasmatic nucleus: In situ hybridization of glutamic acid decarboxylase and immunocytochemistry of GAD and GABA. Neurosci Lett 102:131-136.
18. Pitkänen A and Amaral DG (1994) The distribution of GABA-ergic cells, fibers, and terminals in the monkey amygdaloid complex: An immunohistochemial and in situ hybridization study. J Neurosci 14:2200-2224.
19. Stahl WL, Eakin TJ, and Baskin DG (1993) Selection of oligonucleotide probes for detection of mRNA isoforms. J Histochem Cytochem 41:1735-1740.
20. Swaab DF, Fliers E, and Partiman TS (1985) The suprachiasmatic nucleus of the human brain in relation to sex, age and senile dementia. Brain Res 342:37-44.
21. van den Pol AN (1980) The hypothalamic suprachiasmatic nucleus of the rat: Intrinsic anatomy. J Comp Neurol 191:661-702.
22. Watts AG (1991) The efferent projections of the suprachiasmatic nucleus: Anatomical insights into the control of circadian rhythms. In The Suprachiasmatic Nucleus: The Mind's Clock, DC Klein, RY Moore, and SM Reppert, eds, pp 77-106, Oxford University Press, New York.