Screening of the venoms of two Parabuthus scorpion species on isolated cardiomyocytes

Onderstepoort Journal of Veterinary Research

Volumn 63, Issue 2, 1996, Pages 127-130

  Van Aarde, M N ^a   Van Rooyen, J M ^a   Van Aswegen, G ^a  

^a NORTH WEST UNIVERSITY   (South Africa)

Author keywords

Cardiomyocytes; Parabuthus granulatus; Parabuthus transvaalicus; Scorpion; Venom

Indexed keywords

PARABUTHUS; PARABUTHUS GRANULATUS; PARABUTHUS TRANSVAALICUS; SCORPIONES;

SCORPION VENOM; VENOM ANTISERUM;

ACTIVE TRANSPORT; ANIMAL; ARTICLE; CELL SURVIVAL; COMPARATIVE STUDY; HEART CONTRACTION; HUMAN; PHYSIOLOGY; SCORPION; SPIDER BITE; TIME;

ANIMALS; ANTIVENINS; ARACHNIDISM; BIOLOGICAL TRANSPORT, ACTIVE; CELL SURVIVAL; HUMANS; MYOCARDIAL CONTRACTION; SCORPION VENOMS; SCORPIONS; TIME FACTORS;

EID: 0030159092     PISSN: 00302465     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. BLOOM, S.R. & POLAK, J.M. 1981. Introduction, in Gut hormones, 1-9, edited by S.R. Bloom & J.M. Polak. Edinburgh: Churchill Livingstone.
2. BORNEMAN, J. & HAHIN, R. 1993. Purification of protein toxins from Leiurus quinquestriatus Hebreaus that modify Na channels. Toxicon, 31:1019-1038.
3. BRADFORD, M.M. 1976. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. AnaliticalBiochemistry, 72:248-254.
4. DEBIN, J.A., MAGGIO, J.E. & STRICHARTZ, G.R. 1993. Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion. American Journal of Physiology, 264:C361-C369.
5. GONOI, T. & HILLE, B. 1987. Gating of Na channels. Journal of General Physiology, 89:253-274.
6. GUERON, M., ILIA, R.E. & SOFER, S. 1993. Scorpion venom cardiomyopathy. American Heart Journal, 125:1816.
7. HAMILL, O.P., MARTY, A., NEHER, E., SAKMAN, B. & SIGWORTH, F.J., 1981. Improved patch-clamp for high resolution current recordings from cells and cell free membrane patches. Pflügers Archiv. 391:85-100.
8. HILLE, B. 1992. Ionic channels of excitable membranes, 2nd ed. Massachusetts: Sinauer.
9. KAWAI, N. 1991. Neuroactive toxins of spider venoms. Journal of Toxicology-Toxin Reviews, 10:131-167.
10. KIRSCH, G.E., SKATTEBOL, A., POSSANI, I.D. & BROWN, A.M. 1989. Modification of Na channel gating by an a scorpion toxin. Journal of General Physiology, 93:67-83.
11. MELCHIORRI, P. & ERSPARMER, V. 1981. New amphibian peptides, in Gut hormones, edited by S.R. Bloom, & J.M. Polak. Edinburgh: Churchill Livingstone: 39-42.
12. MITRA, R. & MORAD, M. 1985. A uniform method for dissociation of myocytes from the heart and stomachs of vertebrates. American Journal of Physiology, 249:H1056-H1060.
13. MÜLLER, G.J. 1993. Scorpionism in South Africa. South African Medical Journal, 83:405-411.
14. STRONG, P.N. 1990. Potassium channel toxins. Pharmacological Therapeutics, 46:137-162.
15. VAN DERWALT, M.P.K., VAN ROOYEN, J.M., OBERHOLZER, G. & VAN ASWEGEN, G. 1992. Cardiotoxicity of the skin of the red-banded rubber frog, Phrynomerus bifasciatus (Smith 1847). Onderstepoort Journal of Veterinary Research, 59:107-109.
16. YATANI, A., KIRSCH, G.E., POSSANI, L.D. & BROWN, A.M. 1988. Effects of New World scorpion toxins on single channel and whole-cell cardiac sodium currents. American Journal of Physiology, 254:H443-H452.