Clearance of the α2macroglobulin-trypsin complex and uptake of trypsin by perfused liver

Brazilian Journal of Medical and Biological Research

Volumn 29, Issue 6, 1996, Pages 797-803

  Nagaoka, M R ^a   Kouyoumdjian, M ^a   Borges, D R ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

2m Trypsin complex; 2Macroglobulin; Acute phase reaction; Liver clearance; Trypsin

Indexed keywords

ALPHA 2 MACROGLOBULIN; ALPHA 2 MACROGLOBULIN TRYPSIN COMPLEX; ALPHA-2-MACROGLOBULIN-TRYPSIN COMPLEX; TRYPSIN;

ACUTE PHASE RESPONSE; ANIMAL; ARTICLE; IN VITRO STUDY; LIVER; MALE; METABOLISM; PERFUSION; RAT; WISTAR RAT;

ACUTE-PHASE REACTION; ALPHA-MACROGLOBULINS; ANIMALS; LIVER; MALE; PERFUSION; RATS; RATS, WISTAR; TRYPSIN;

EID: 0030155652     PISSN: 0100879X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. 2-macroglobulin-trypsin complex and early recognition of severe acute pancreatitis after endoscopic retrograde pancreatography. Journal of Gastroenterology and Hepatology, 9: 272- 276.
2. Levine JJ & Pettei MJ (1991). Liver uptake of trypsin-inhibitor complexes: Differences between suckling and adult rats. Biology of the Neonate, 60: 230-235.
3. Lonberg-Holm K, Reed DL, Roberts RC, Hebert RR, Hillman MC & Kutney RM (1987). Three high molecular weight protease inhibitors of rat plasma. Journal of Biological Chemistry. 262: 438-445.
4. 2macroglobulin-trypsin complexes in hepatocytes and adipocytes. Biochimica et Biophysica Acta, 756: 230-237.
5. Sottrup-Jensen L (1989). α-Macroglobulins: structure, shape, and mechanism of proteinase complex formation. Journal of Biological Chemistry. 264: 11539-11542.
6. 2-macroglobulin to hepatocytes: Mechanism of in vivo clearance. Biochemical and Biophysical Research Communications, 128: 795-802.
7. 2-macroglobulin-trypsin complexes into rat and human cells. FEBS Letters. 188: 352-356.
8. International Guiding Principles for Biomedical Research Involving Animals by the Council for International Organizations of Medical Sciences (CIOMS) (1985). Geneva, Switzerland, 1-28.
9. Gordon H (1976). The alpha-macroglobulins of rat serum. Biochemical Journal, 159: 643-650.
10. Mancini G, Carbonara AO & Heremans JF (1965). Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry, 2: 235-254.
11. Kouyoumdjian M, Borges DR, Michelacci YM, Guimarães JA, Sampaio CAM & Prado JL (1987). Purification and characterization of the alpha form of rat plasma kallikrein. Brazilian Journal of Medical and Biological Research, 20: 549-552.
12. 2macroglobulin in serum from injured rats. Biochimica et Biophysica Acta, 668: 257-267.
13. Chase T & Shaw E (1967). p-Nitrophenylp-guanidinobenzoate MCI: a new active site titrant for trypsin. Biochemical and Biophysical Research Communications, 29: 508-514.
14. 2macroglobulin as trypsin-protein esterase. Clinica Chimica Acta, 14: 493-501.
15. Borges DR & Kouyoumdjian M (1992). The recognition site for hepatic clearance of plasma kallikrein is on its heavy chain and is latent on prokallikrein. Journal of Hepatology, 16: 115-121.
16. 125-labeled asialo-fetuin in isolated rat hepatocytes. Biochemical Pharmacology, 29: 917- 925.
17. Freeman T, Gordon AH & Humphrey JH (1958). Distinction between catabolism of native and denatured proteins by the isolated perfused liver after carbon loading. British Journal of Experimental Pathology, 39: 459-471.
18. van der Sluijs P, Braakman I, Meijer DKF & Groothuis GMM (1988). Heterogeneous acinar localization of the asialoglycoprotein internalization system in rat hepatocytes. Hepatology, 8: 1521-1529.
19. 2-macroglobulin: Evidence for alternate reaction pathways in the inhibition of trypsin. Biochemistry, 28: 7636-7643.
20. Loureiro-Silva MR, Kouyoumdjian M & Borges DR (1993). Plasma kallikrein and thrombin are cleared through unrelated hepatic pathways. Blood Coagulation and Fibrinolysis, 4: 551-554.
21. Collins PW, Macey MG, Cahill MR & Newland AC (1993). von Willebrand factor release and P-selectin expression is stimulated by thrombin and trypsin but not IL-1 in cultured human endothelial cells. Thrombosis and Haemostasis, 70: 346-350.
22. Chakraborti S & Michael JR (1991). Involvement of a serine esterase in oxidant-mediated activation of phospholipase A2 in pulmonary endothelium. FEBS Letters. 281: 185-187.
23. Rabito SF, Seichi AG, KherV & Carretero OA (1982). Immunoreactive glandular kallikrein in rat plasma: a radioimmunoassay for its determination. American Journal of Physiology, 242: H602-H610.
24. Kouyoumdjian M, Borges DR, Prado ES & Prado JL (1989). Identification of receptors in the liver that mediate endocytosis of circulating tissue kallikreins. Biochimica et Biophysica Acta, 980: 299-304.
25. Chao J, Tillmann DM, Wang M, Margolius HS & Chao L (1986). Identification of a new tissue-kallikrein-binding protein. Biochemical Journal, 239: 325-331.
26. 2-macroglobulin receptor containing a cluster of eight complement-type repeats. Journal of Biological Chemistry, 268: 13691-13696.
27. 2macroglobulin receptor (low density lipoprotein receptor-related protein). Journal of Biological Chemistry, 266: 14011-14017.
28. Ogata H, Kouyoumdjian M & Borges DR (1993). Comparison between clearance rates of plasma kallikrein-α-macroglobulins complexes by the liver. International Journal of Biochemistry, 25: 1047-1051.
29. 2macroglobulin-plasmin complexes with isolated hepatocytes. Biochimica et Biophysica Acta, 845: 389-395.
30. Fitch P, Bennett B, Booth NA, Croll A & Ewen SWB (1994). Distribution of plasminogen activator inhibitor in normal liver, cirmotic liver, and liver with metastases. Journal of Clinical Pathology, 47: 218-221.
31. Wong MWC & Jamieson JC (1979). Evidence for reduced uptake of asialo-ociacid glycoprotein during the acute phase response to inflammation. Life Sciences, 25: 827-834.
32. Martins B, Kouyoumdjian M, Limãos EA & Borges DR (1992). The clearance rate of plasma kallikrem by the liver increases during the acute-phase response to inflammation. Agents and Actions, 37: 111-113.
33. Le Moine O, Devaster JM, Deviére J, Thiry P, Cremer M & Ooms HA (1994). Trypsin activity - A new marker of acute alcoholic pancreatitis. Digestive Diseases and Sciences, 39: 2634-2638.