Hyperglycemia decreases dehydroepiandrosterone in Japanese male with impaired glucose tolerance and low insulin response

Endocrine Journal

Volumn 43, Issue 3, 1996, Pages 285-290

  Yamauchi, Akira ^a   Takei, Izumi ^a   Nakamoto, Shinya ^a   Ohashi, Norimi ^a   Kitamura, Yuko ^a   Tokui, Mikiya ^a   Nakano, Satomi ^a   Takayama, Sumiyo ^a   Kasuga, Akira ^a   Katsukawa, Fuminori ^a   Saruta, Takao ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Dehydroepiandrosterone (DHEA); Hyperglycemia; Hyperinsulinemia; Impaired glucose tolerance (IGT); Oral glucose tolerance test (OGTT)

Indexed keywords

PRASTERONE;

ARTICLE; BLOOD; DIABETES MELLITUS; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HUMAN; HYPERGLYCEMIA; INSULIN RESISTANCE; JAPAN; MALE; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; TIME;

DEHYDROEPIANDROSTERONE; DIABETES MELLITUS; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HUMANS; HYPERGLYCEMIA; INSULIN RESISTANCE; JAPAN; MALE; MIDDLE AGED; TIME FACTORS;

EID: 0030155552     PISSN: 09188959     EISSN: None     Source Type: Journal    
DOI: 10.1507/endocrj.43.285     Document Type: Article

References (34)

1. Barret-Conner E, Khaw KT, Yen SSC (1986) A prospective study of dehydroepiandrosterone sulfate, mortality and cardiovascular disease. N Engl J Med 315: 1519-1524.
2. Gray A, Feldman HA, McKinlay JB, Longcope C (1991) Age, disease, and changing sex hormone levels in middle-aged men: Results of the Massachusetts male aging study. J Clin Endocrinol Metab 73: 1016-1025.
3. Slowinska-Szednicka J, Zgliczynski S, Ciswicka-Sznajderman M, Srzednicki M, Soszynski P, Biernacka M, Woroszylska M, Ruzyllo W, Sadowski Z (1989) Decreased plasma dehydroepiandrosterone sulfate and dihydrotestosterone concentrations in young men after myocardial infarction. Atherosclerosis 79: 197-203.
4. Ben-David M, Dikstein S, Bismuth G, Sulman FG (1967) Anti-hypercholesterolemic effect of dehydroepiandrosterone in rats. Proc Soc Exp Biol Med 125: 1136-1140.
5. Gordon GB, Bush DE, Weisman HF (1988) Reduction of atherosclerosis by administration of dehydroepiandrosterone. A study in the hypercholesterolemic New Zealand White rabbit with aortic intimal injury. J Clin Invest 82: 712-720.
6. Kurzman ID, MacEwen EG, Haffa ALM (1990) Reduction in body weight and cholesterol in spontaneously obese dogs by dehydroepiandrosterone. Int J Obesity 14: 95-104.
7. Cleary MP, Shepherd A, Jenks B (1984) Effect of dehydroepiandrosterone on growth in lean and obese Zucker rats. J Nutr 114: 1242-1251.
8. Cleary MP (1991) The antiobesity effect of dehydroepiandrosterone in rats. Proc Soc Exp Biol Med 196: 8-16.
9. Coleman DL, Leiter EH, Schwizer RW (1982) Therapeutic effect of dehydroepiandrosterone (DHEA) in diabetic mice. Diabetes 31: 830-833.
10. Coleman DL, Schwizer RW, Leiter EH (1984) Effect of genetic background on the therapeutic effects of dehydroepiandrosterone (DHEA) in diabetes-obesity mutants and in aged normal mice. Diabetes 33: 26-32.
11. Arad Y, Badimon JO, Badimon L, Hembrec W, Ginsberg HN (1989) Dehydroepiandrosterone feeding prevents aortic fatty streak formation and cholesterol accumulation in cholesterol-fed rabbits. Arteriosclerosis 9: 159-166.
12. Morales AJ, Nolan JJ, Nelson JC, Yen SSC (1994) Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. J Clin Endocrinol Metab 78: 1360-1367.
13. Reaven GM (1988) Role of insulin resistance in human disease. Diabetes 37: 1595-1607.
14. DeFronzo RA, Ferrannini E (1991) Insulin resistance: A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14: 173-194.
15. Reaven GM (1991) Insulin resistance, hyperinsulinemia, hypertriglyceridemia, and hypertension: parallels between human disease and rodent models. Diabetes Care 14: 195-202.
16. Nestler JE, Clore JN, Blackard WG (1992) Dehydroepiandrosterone: The "missing link" between hyperinsulinemia and atherosclerosis? FASEB J 6: 3073-3075.
17. Nestler JE, Usiskin KS, Barlascini CO, Welty DF, Clore JN, Blackard WG (1989) Suppression of serum dehydroepiandrosterone sulfate levels by insulin: An evaluation of possible mechanisms. J Clin Endocrinol Metab 69: 1040-1046.
18. Diamond MP, Grainger DA, Laudano AJ, Starick-Zych K, DeFronzo RA (1991) Effect of acute physiological elevations of insulin on circulating androgen levels in nonobese women. J Clin Endocrinol Metab 72: 883-887.
19. 4 androstenedione and dehydroepiandrosterone sulfate during oral glucose tolerance test in normal females. J Clin Endocrinol Metab 73: 781-784.
20. Smith S, Ravnikar VA, Barbieri RL (1987) Androgen and insulin response to an oral glucose challenge in hyperandrogenic women. Fertil Steril 48: 72-77.
21. Schriock ED, Buffington CK, Hubert GD, Kurtz BR, Kitabchi AE, Buster JE, Givens JR (1988) Divergent correlation of circulating dehydroepiandrosterone sulfate and testosterone with insulin levels and insulin receptor binding. J Clin Endocrinol Metab 66: 1329-1331.
22. Beer NA, Jakubowicz DJ, Beer RM, Nestler JE (1993) The calcium channel blocker amlodipine raises serum dehydroepiandrosterone sulfate and androstenedione, but lowers serum cortisol, in insulin-resistant obese and hypertensive men. J Clin Endocrinol Metab 76: 1464-1469.
23. Beer NA, Jakubowicz DJ, Beer RM, Arocha IR, Nestler JE (1993) Effects of nitrendipine on glucose tolerance and serum insulin and dehydroepiandrosterone sulfate levels in insulin-resistant obese and hypertensive men. J Clin Endocrinol Metab 76: 178-183.
24. Nestler JE, Beer NA, Jacubowicz DJ, Beer RM(1994) Effects of a reduction in circulating insulin by metformin on serum dehydroepiandrosterone sulfate in nondiabetic men. J Clin Endocrinol Metab 78: 549-554.
25. Nestler JE, Beer NA, Jacubowicz DJ, Colombo C, Beer RM (1994) Effects of insulin reduction with benfluorex on serum dehydroepiandrosterone (DHEA), DHEA sulfate, and blood pressure in hypertensive middle-aged and elderly men. J Clin Endocrinol Metab 80: 700-706.
26. Barrett-Connor E (1992) Lower endogenous androgen levels and dyslipidemia in men with non-insulin dependent diabetes mellitus. Annals of Intern Med 117: 807-811.
27. Couch RM (1992) Dissociation of cortisol and adrenal androgen secretion in poorly controlled insulin-dependent diabetes mellitus. Acta Endocrinol 127: 115-117.
28. Yamauchi A, Takei I, Kasuga A, Kitamura Y, Ohashi N, Nakano S, Takayama S, Nakamoto S, Katsukawa F, Saruta T (1996) The depression of dehydroepiandrosterone in Japanese diabetic men -comparison between NIDDM and IGT. Europ J Endocrinol (In press).
29. Kosaka K, Hagura R, Kuzuya T, Kuzuya N (1974) Insulin secretory response of diabetics during the period pf improvement of glucose tolerance to normal range. Diabetologia 10: 775-782.
30. Kosaka K, Hagura R, Kuzuya T (1977) Insulin responses in equivocal and definite diabetes, with special reference to subjects who had mild glucose intolerance but later developed definite diabetes. Diabetes 26: 944-952.
31. Nestler JE, McClanahan MA, Clore JN, Blackard WG (1992) Insulin inhibits adrenal 17, 20-lyrase activity in men. J Clin Endocrinol Metab 74: 362-367.
32. Karwash Z, OminBrien R, Nestler JE (1993) Insulin acutely increases the metabolic clearance rate (MCR) of dehydroepiandrosterone (DHEA) in men. Clin Res 41: 800A (Abstract).
33. Parker LN, Levin ER, Lifrak ET (1985) Evidence for adrenocortical adaptation to severe illness. J Clin Endocrinol Metab 60: 947-952.
34. Semple GC, Gray CE, Beatall GH (1987) Adrenal androgens and illness. Acta Endocrinol (Copenh) 116: 155-160.