Activated C protein resistance laboratory study and prevalence of the defect in Chile;Resistencia a la proteina C activada: Estudio de laboratorio y prevalencia del defecto en la población chilena

Revista Medica de Chile

Volumn 124, Issue 6, 1996, Pages 663-668

  Pereira G, Jaime ^a,b   Quiroga G, Teresa ^a   Goycoolea M, Manuela ^a   Munoz V, Blanca ^a   Hidalgo P, Patricia ^a   Kaltwasser G, Gustavo ^a   Mezzano A, Diego ^a  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 5; PROTEIN C;

ARTICLE; BLOOD CLOTTING FACTOR 5 DEFICIENCY; CHILE; DISEASE PREDISPOSITION; GENETICS; HUMAN; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PARTIAL THROMBOPLASTIN TIME; PHYSIOLOGY; POINT MUTATION; POLYMERASE CHAIN REACTION;

BASE SEQUENCE; CHILE; DISEASE SUSCEPTIBILITY; FACTOR V; FACTOR V DEFICIENCY; HUMANS; MOLECULAR SEQUENCE DATA; PARTIAL THROMBOPLASTIN TIME; POINT MUTATION; POLYMERASE CHAIN REACTION; PROTEIN C;

EID: 0030155494     PISSN: 00349887     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. WEINMANN EE, SAIZMAN EW. Deep-vein thrombosis. N Engl J Med 1994; 331: 1630-41.
2. NACHMAN RL, SILVERSTEIN R. Hypercoagulable states. Ann Intern Med 1993; 119: 819-27.
3. GREAVES M, PRESTON FF. The hypercoagulable state in clinical practice. Br J Heamatol 1991; 79 148-51.
4. RODGERS GM, CHANDLER WL. Laboratory and clinical aspects of inherited thrombotic disorders. Am J Hematol 1992; 41: 113-22
5. DAHLBÄCK B, CARLSSON M, SVENSSON PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C. Proc Natl Acad Sci 1993; 90: 1004-08.
6. KOSTER T, ROSENDAAL FR, DE RONDE F, BRIET E, VANDENBROUCKE JP, BERTINA RM. Venous thrombosis due to poor response to activated protein C: Leiden thrombophilia study. Lancet 1993; 342: 1503-06.
7. SVENSSON PJ, DAHLBÄCK H. Novel mechanism for thrombosis characterized by poor anticoagulant response to activated protein C constitutes a major cause of thrombophilia. Thromb Haemost 1993; 69: 999.
8. GRIFFIN JH, EVATT B, WIDESMAN C, FERNANDEZ JA. Anticoagulant protein C pathway defective in a majority othrombophilic patients. Blood 1993; 82: 1989-93.
9. BEAUCHAMP NJ, DALY ME, HAMPTON KK, COOPER PC, PRESTON E, PEAKE IR. High prevalence of a mutation in the factor V gene within the UK population: Relationship to activated protein C resistance and familial thrombosis. Br J Haematol 1994; 88: 219-22.
10. BERTINA RM, KOELEMAN BPC, KOSTER T, ROSENDAAL FR, DIRVEN RH, DE RONDE H, VAN DER VELDEN PA, REITSMA PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-7.
11. VOORBERG J, ROELSE J, KOOPMAN R, BÜLLER H, BERENDS F, TEN CATE: JT, MERTENS K, VAN MOURIK JA. Association of idiopathic thromboembolism with single point mutation at Arg506 of factor V. Lancet; 94; 343: 1535-36.
12. R506Q. J Biol Chem 1995; 270: 4053-57.
13. DE RONDE H, BERTINA RM. Laboratory diagnosis of APC-resistance: a critical evaluation of the test and the development of diagnostic criteria. Thromb Haemost 1994: 72; 880-86.
14. SVENSSON PJ, DAHLBÄCK B. Resistance to activated protein C as a basis for venous thrombosis. N Engl J Med 1994; 330: 517-22.
15. RIDKER PM, HENNEKENS CH, LINDPAINTER K ET AL. Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke and venous thrombosis in apparently healthy men. N Engl J Med 1995; 332: 912-17.
16. CRIPE LD, MOORE KD, KANE WH. Structure of the gene for human coagulation factor V. Biochemistry 1992; 31: 3777-85.
17. HELLGREN M, SVENSSON PJ DAHLBÄCK B. Resistance to activated protein C as a basis for venous thromboembolism associated with pregnancy and oral contraceptives. Am J Obstet Gyn 1995; 173: 210-13.
18. EHRENFORTH S, RADTKE KP, SCHARRER I. Acquired activated protein C resistance in patients with lupus anticoagulants, Thromb Haemost 1995; 74: 797-98.