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Volumn 138, Issue 2, 1996, Pages 317-323

The peroxisome proliferators WY-14,643 and methylclofenapate induce hepatocyte ploidy alterations and ploidy-specific DNA synthesis in F344 rats

Author keywords

[No Author keywords available]

Indexed keywords

METHYLCLOFENAPATE; PEROXISOME PROLIFERATOR; PIRINIXIC ACID; BROXURIDINE; PYRIMIDINE DERIVATIVE;

EID: 0030153488     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.0130     Document Type: Article
Times cited : (20)

References (23)
  • 1
    • 0025334267 scopus 로고
    • Mitosis and histopathology in rat liver during methylclofenapate-induced hyperplasia
    • Bybee, A., Styles, J. A., Beck, S. L., and Blackburn, D. (1990). Mitosis and histopathology in rat liver during methylclofenapate-induced hyperplasia. Cancer Lett. 52, 95-100.
    • (1990) Cancer Lett. , vol.52 , pp. 95-100
    • Bybee, A.1    Styles, J.A.2    Beck, S.L.3    Blackburn, D.4
  • 2
    • 0014650975 scopus 로고
    • The growth of liver parenchymal nuclei and its endocrine regulation
    • Carriere, R. (1969). The growth of liver parenchymal nuclei and its endocrine regulation. Int. Rev. Cytol. 25, 201-277.
    • (1969) Int. Rev. Cytol. , vol.25 , pp. 201-277
    • Carriere, R.1
  • 3
    • 0028267158 scopus 로고
    • Computer simulation of cell growth governed by stochastic processes: Application to clonal growth cancer models
    • Conolly, R. B., and Kimbell, J. S. (1994). Computer simulation of cell growth governed by stochastic processes: Application to clonal growth cancer models. Toxicol. Appl. Pharmacol. 124, 284-295.
    • (1994) Toxicol. Appl. Pharmacol. , vol.124 , pp. 284-295
    • Conolly, R.B.1    Kimbell, J.S.2
  • 4
    • 0024241608 scopus 로고
    • Relationship of hepatic peroxisome proliferation and replicative DNA synthesis of the peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (WY-14,643) in rats
    • Marsman, D. S., Cattley, R. C., Conway, J. G., and Popp, J. A. (1988). Relationship of hepatic peroxisome proliferation and replicative DNA synthesis of the peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (WY-14,643) in rats. Cancer Res. 48, 6739-6744.
    • (1988) Cancer Res. , vol.48 , pp. 6739-6744
    • Marsman, D.S.1    Cattley, R.C.2    Conway, J.G.3    Popp, J.A.4
  • 5
    • 0027372446 scopus 로고
    • Ploidy and nuclearity of rat hepatocytes after compensatory regeneration or mitogen induced liver growth
    • Melchiorri, C., Chieco, P., Zedda, A. I., Coni, P., Ledda-Columbano, G. M., and Columbano, A. (1993). Ploidy and nuclearity of rat hepatocytes after compensatory regeneration or mitogen induced liver growth. Carcinogenesis 14, 1825-1830.
    • (1993) Carcinogenesis , vol.14 , pp. 1825-1830
    • Melchiorri, C.1    Chieco, P.2    Zedda, A.I.3    Coni, P.4    Ledda-Columbano, G.M.5    Columbano, A.6
  • 7
    • 0026638937 scopus 로고
    • Interpretation of labeling indices in the presence of cell death
    • Moolgavkar, S. H., and Luebeck, E. G. (1992). Interpretation of labeling indices in the presence of cell death. Carcinogenesis 13, 1007-1010.
    • (1992) Carcinogenesis , vol.13 , pp. 1007-1010
    • Moolgavkar, S.H.1    Luebeck, E.G.2
  • 8
    • 0021051308 scopus 로고
    • Carcinogenesis by hepatic peroxisome proliferators: Evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans
    • Reddy, J. K., and Lalwani, N. D. (1983). Carcinogenesis by hepatic peroxisome proliferators: Evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans. Crit. Rev. Toxicol. 12, 1-58.
    • (1983) Crit. Rev. Toxicol. , vol.12 , pp. 1-58
    • Reddy, J.K.1    Lalwani, N.D.2
  • 9
    • 0020079248 scopus 로고
    • Excessive accumulation of autofluorescent lipofuscin in the liver during hepatocarcinogenesis by methylclofenapate and other hypolipidemic peroxisome proliferators
    • Reddy, J. K., Lalwani, N. D., Reddy, M. K., and Qureshi, S. A. (1982a). Excessive accumulation of autofluorescent lipofuscin in the liver during hepatocarcinogenesis by methylclofenapate and other hypolipidemic peroxisome proliferators. Cancer Res. 42, 259-266.
    • (1982) Cancer Res. , vol.42 , pp. 259-266
    • Reddy, J.K.1    Lalwani, N.D.2    Reddy, M.K.3    Qureshi, S.A.4
  • 10
    • 0018345144 scopus 로고
    • Mitogenic and carcinogenic effects of a hypolipidemic peroxisome proliferator [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14,643), in rat and mouse liver
    • Reddy, J. K., Rao, M. S., Azarnoff, D. L., and Snell, S. (1982b). Mitogenic and carcinogenic effects of a hypolipidemic peroxisome proliferator [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14,643), in rat and mouse liver. Cancer Res. 39, 152-161.
    • (1982) Cancer Res. , vol.39 , pp. 152-161
    • Reddy, J.K.1    Rao, M.S.2    Azarnoff, D.L.3    Snell, S.4
  • 12
    • 0018822510 scopus 로고
    • Adaptive responses of rat liver to the gestagen and anti-androgen cyproterone acetate and other inducers. III. Cytological changes
    • Schulte-Hermann, R., Hoffmann, V., and Landgraf, H. (1980). Adaptive responses of rat liver to the gestagen and anti-androgen cyproterone acetate and other inducers. III. Cytological changes. Chem. - Biol. Interact. 31, 301-311.
    • (1980) Chem. - Biol. Interact. , vol.31 , pp. 301-311
    • Schulte-Hermann, R.1    Hoffmann, V.2    Landgraf, H.3
  • 13
    • 0021207486 scopus 로고
    • Emergence of a population of small, diploid hepatocytes during hepatocarcinogenesis
    • Schwarze, P. E., Pettersen, E. O., Shoaib, M. C., and Seglen, P. O. (1984). Emergence of a population of small, diploid hepatocytes during hepatocarcinogenesis. Carcinogenesis 5, 1267-1275.
    • (1984) Carcinogenesis , vol.5 , pp. 1267-1275
    • Schwarze, P.E.1    Pettersen, E.O.2    Shoaib, M.C.3    Seglen, P.O.4
  • 14
    • 0025052559 scopus 로고
    • Growth-related alterations during liver carcinogenesis: Effect of promoters
    • Seglen, P. O., and Gerlyng, P. (1990). Growth-related alterations during liver carcinogenesis: Effect of promoters. Environ. Health Perspect. 88, 197-205.
    • (1990) Environ. Health Perspect. , vol.88 , pp. 197-205
    • Seglen, P.O.1    Gerlyng, P.2
  • 15
    • 0018910080 scopus 로고
    • Involvement of the iodothyronines in liver and hepatoma cell proliferation in the rat
    • Short, J., Klein, K., Kibert, L., and Ove, P. (1980). Involvement of the iodothyronines in liver and hepatoma cell proliferation in the rat. Cancer Res. 40, 2417-2422.
    • (1980) Cancer Res. , vol.40 , pp. 2417-2422
    • Short, J.1    Klein, K.2    Kibert, L.3    Ove, P.4
  • 16
    • 0025348696 scopus 로고
    • Studies on the hyperplastic response of binucleated rat hepatocytes
    • Styles, J. A., Bybee, A., Pritchard, N. R., and Kelly, M. D. (1990). Studies on the hyperplastic response of binucleated rat hepatocytes. Carcinogenesis 11, 1149-1152.
    • (1990) Carcinogenesis , vol.11 , pp. 1149-1152
    • Styles, J.A.1    Bybee, A.2    Pritchard, N.R.3    Kelly, M.D.4
  • 17
    • 0021979252 scopus 로고
    • Irreversible depression in the ratio of tetraploid:Diploid liver nuclei in rats treated with 3′-methyl-4-dimethyl-aminoazobenzene (3′M)
    • Styles, J. A., Elliott, B. M., Lefevre, P. A., Robinson, M., Pritchard, N., Hart, D., and Ashby, J. (1985). Irreversible depression in the ratio of tetraploid:diploid liver nuclei in rats treated with 3′-methyl-4-dimethyl-aminoazobenzene (3′M). Carcinogenesis 6, 21-28.
    • (1985) Carcinogenesis , vol.6 , pp. 21-28
    • Styles, J.A.1    Elliott, B.M.2    Lefevre, P.A.3    Robinson, M.4    Pritchard, N.5    Hart, D.6    Ashby, J.7
  • 18
    • 0023212221 scopus 로고
    • A cytological comparison between regeneration, hyperplasia and early neoplasia in the rat liver
    • Styles, J. A., Kelly, M., and Elcombe, C. R. (1987). A cytological comparison between regeneration, hyperplasia and early neoplasia in the rat liver. Carcinogenesis 8, 391-399.
    • (1987) Carcinogenesis , vol.8 , pp. 391-399
    • Styles, J.A.1    Kelly, M.2    Elcombe, C.R.3
  • 19
    • 0023769551 scopus 로고
    • A species comparison of acute hyperplasia induced by the peroxisome proliferator methylclofenapate: Involvement of the binucleated hepatocytes
    • Styles, J. A., Kelly, M., Pritchard, N. R., and Elcombe, C. R. (1988). A species comparison of acute hyperplasia induced by the peroxisome proliferator methylclofenapate: Involvement of the binucleated hepatocytes. Carcinogenesis 9, 1647-1655.
    • (1988) Carcinogenesis , vol.9 , pp. 1647-1655
    • Styles, J.A.1    Kelly, M.2    Pritchard, N.R.3    Elcombe, C.R.4
  • 20
    • 0002438717 scopus 로고
    • Hypocholesterolemic and other effects of methylclofenapate, a novel derivative of clofibrate
    • Thorp, J. (1970). Hypocholesterolemic and other effects of methylclofenapate, a novel derivative of clofibrate. Atheroscler. Proc. Second Int. Symp. 541-544.
    • (1970) Atheroscler. Proc. Second Int. Symp. , pp. 541-544
    • Thorp, J.1
  • 21
    • 0023292769 scopus 로고
    • The kinetics of nuclear polyploidization and tumour formation in livers of CF-1 mice exposed to dieldrin
    • van Ravenzwaay, B., Tennekes, H., Stöhr, M., and Kunz, W. (1987). The kinetics of nuclear polyploidization and tumour formation in livers of CF-1 mice exposed to dieldrin. Carcinogenesis 8, 265-269.
    • (1987) Carcinogenesis , vol.8 , pp. 265-269
    • Van Ravenzwaay, B.1    Tennekes, H.2    Stöhr, M.3    Kunz, W.4
  • 22
    • 77957177553 scopus 로고
    • Dose-related effects of the hepatocarcinogen, Wy-14,643, on peroxisomes and cell replication
    • Wada, N., Marsman, D. S., and Popp, J. A. (1992). Dose-related effects of the hepatocarcinogen, Wy-14,643, on peroxisomes and cell replication. Fundam. Appl. Toxicol. 18, 149-154.
    • (1992) Fundam. Appl. Toxicol. , vol.18 , pp. 149-154
    • Wada, N.1    Marsman, D.S.2    Popp, J.A.3
  • 23
    • 0014816935 scopus 로고
    • DNA synthesis in polyploid and binucleate hepatic cells in the regenerating rat liver of different ages
    • Watanabe, M. (1970). DNA synthesis in polyploid and binucleate hepatic cells in the regenerating rat liver of different ages. Nagoya J. Med. Sci. 33, 1-11.
    • (1970) Nagoya J. Med. Sci. , vol.33 , pp. 1-11
    • Watanabe, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.