Effect of combined B1 and B2 kinin receptor blockade in porcine endotoxin shock

Immunopharmacology

Volumn 33, Issue 1-3, 1996, Pages 81-84

  Siebeck, Matthias ^a   Spannagl, Erwin ^a   Schorr, Markus ^a   Stumpf, Bernhard ^a   Fritz, Hans ^a   Whalley, Eric T ^b   Cheronis, John C ^b  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b Departments of New Leads Chemistry and Pharmacology   (United States)

Author keywords

B1 and B2 bradykinin receptor antagonist; LPS shock; pathophysiology; pig

Indexed keywords

BRADYKININ B1 RECEPTOR; BRADYKININ B1 RECEPTOR ANTAGONIST; BRADYKININ B2 RECEPTOR; BRADYKININ B2 RECEPTOR ANTAGONIST; DELTIBANT; KALLIDIN[9 LEUCINE 10 DEARGININE]; LIPOPOLYSACCHARIDE; SALMONELLA ENDOTOXIN; UNCLASSIFIED DRUG; BRADYKININ RECEPTOR; BRADYKININ, LYS LEU(8) DESARG(9); BRADYKININ, LYS-LEU(8)-DESARG(9)-; DRUG DERIVATIVE; KALLIDIN; PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; DRUG ANTAGONISM; HOST RESISTANCE; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SEPTIC SHOCK; SURVIVAL RATE; SWINE; ANIMAL; ARTICLE; DISEASE MODEL; DRUG INTERACTION; RANDOMIZATION;

ANIMALS; DISEASE MODELS, ANIMAL; DRUG INTERACTIONS; KALLIDIN; LIPOPOLYSACCHARIDES; PEPTIDES; RANDOM ALLOCATION; RECEPTOR, BRADYKININ B1; RECEPTOR, BRADYKININ B2; RECEPTORS, BRADYKININ; SHOCK, SEPTIC; SWINE;

EID: 0030153311     PISSN: 01623109     EISSN: None     Source Type: Journal    
DOI: 10.1016/0162-3109(96)00060-4     Document Type: Conference Paper

References (13)

1. Cheronis, J.C., Whalley, E.T., Nguyen, K.T., Eubanks, S,R., Allen, L.G., Duggan, M.J., Loy, S.D., Bonham, K.A. and Blodgett, J.K. (1992). A new class of bradykinin antagonists: Synthesis and in vitro activity of bissuccinimidoalkane peptide dimers. J Med Chem 35:1563-1572.
2. DeLa Cadena, R.A., Suffredini, A.F., Page, J.D., Pixley, R.A., Kaufman, N., Parrillo, J.E. and Colman, R.W. (1993). Activation of the kallikrein-kinin system after endotoxin administration to normal human volunteers. Blood 81:3313-3317.
3. Kalter, E.S., van Dijk, W.C., Timmermann, A., Verhoef, J. and Bouma, B.N. (1983). Activation of purified human plasma prekallikrein triggered by cell wall fractions of Excherichia coli and Staphylococcus aureus. J Infect Dis 148:682-691.
4. 1 receptors: a review, Immunopharmacology 30:1-26.
5. Regoli, D., Marceau, F. and Barabé. J. (1978). De novo formation of vascular receptors for bradykinin. Can J Physiol Pharmacol 56:674-677.
6. Ridings, P.C., Sugerman, H.J., Blocher, C.R., Fisher, B.J. and Fowler, A.A. (1995). Hemodynamic effects of bradykinin antagonism in porcine Gram-negative sepsis. J Invest Surg 8:115-122.
7. Schremmer-Danninger, E., Öffner, A., Siebeck, M., Heinz-Erian, P., Gais, P. and Roscher, A.A. (1995). Autoradiographic visualisation of B1 bradykinin receptors in porcine vascular tissue m the presence or absence of inflammation Immunopharmacology, 33, 95-100.
8. 9-bradykinin increases during E. coli septicemia in the pig. Adv Exp Med Biol 2476:389-393.
9. Siebeck, M., Fink, E., Weipert, J., Jochum, M., Fritz, H., Spannagl, M., Kroworsch, P., Shimamoto, K. and Schweiberer, L. (1993). Inhibition of plasma kallikrein with aprotinin in porcine endotoxin shock. J Trauma 34:193-198.
10. 1 kinin receptor activity is associated with pre-existing inflammation in pigs (abstract). Shock 3(Suppl):61.
11. 2 bradykinin receptors in bovine pulmonary artery endothelial cells. Mol Pharmacol 47:525-534.
12. Ueno, A., Ishida, H. and Ohishi, S. (1995). Comparative study of endotoxin-induced hypotension in kininogen-deficient rats with that in normal rats. Br J Pharmacol 114:1250-1256.
13. 7]-Bk (B4148). Br J Pharmacol 94:282-284.