A facile method for the labeling of proteins with zirconium isotopes

Nuclear Medicine and Biology

Volumn 23, Issue 4, 1996, Pages 439-448

  Meijs, Wilma E ^a   Haisma, Hidde J ^b   Van Der Schors, Roel ^a   Wijbrandts, René ^a   Van Den Oever, Karin ^a   Klok, Rob P ^a   Pinedo, Herbert M ^b   Herscheid, Jacobus D M ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Desferal; Protein labeling; Zirconium 88; Zirconium 89

Indexed keywords

CITRIC ACID; DEFEROXAMINE; DEFEROXAMINE MESYLATE; PROTEIN; UNCLASSIFIED DRUG; ZIRCONIUM 88; ZIRCONIUM 89; ZIRCONIUM DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; INTRAVENOUS DRUG ADMINISTRATION; ISOTOPE LABELING; MOUSE; PHARMACOKINETICS; POSITRON EMISSION TOMOGRAPHY;

EID: 0030152944     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/0969-8051(96)00020-0     Document Type: Article

References (41)

1. 1. Arano Y., Inoue T., Mukai T., Wakisaka K., Sakahara H., Konishi J. and Yokoyama A. (1994b) Discriminated release of a hippurate-like radiometal chelate in nontarget tissues for target-selective radioactivity localization using pH-dependent dissociation of reduced antibody. J. Nucl. Med. 35, 326-333.
2. 2. Arano Y., Matsushima H., Tagawa M., Inoue T., Koizumi M., Hosono M., Sakahara H., Endo K., Konihi J. and Yokoyama A. (1994a) A newly designed radioimmuno conjugate releasing a hippurate-like radiometal chelate for enhanced target/nontarget radioactivity. Nucl. Med. Biol. 21, 63-69.
3. 89Zr, a potential PET antibody label. Appl. Radiat. Isot. 41, 789-790.
4. 4. Duncan J. R. and Welch M. J. (1993) Intracellular metabolism of indium-111-DTPA labeled receptor targeted proteins. J. Nucl. Med. 34, 1728-1738.
5. 5. Fletcher C. R. (1969) The radiological hazards of zirconium-95 and niobium-95. Health Phys. 16, 209-220.
6. 111In-DTPA-∈-lysme as the primary metabolic and excretory product. Nucl. Med. Biol. 21, 1023-1034.
7. 7. Garg P. K., Garg S. and Zalutsky M. R. (1991) Fluorine-18 labelling of monoclonal antibodies and fragments with preservation of immunoreactivity. Bioconjug. Chem. 2, 44-49.
8. 8. Haisma H. J., Hilgers J. and Zurawski V. R. Jr. (1986) Iodination of monoclonal antibodies for diagnosis and radiotherapy using a convenient one vial method. J. Nucl. Med. 27, 1890-1895.
9. 9. Herscheid J. D. M., Isaacs H., de Jong R. B. J. and Hoekstra A. (1986) Evaluation of the renal scanning agent N-succinyldesferrioxamine B in dogs. Eur. J. Nucl. Med. 11, 363-364.
10. 10. Hnatowich D. J., Griffin T. W., Kosciuczyk C., Rusckowski M., Childs R. L., Mattis J. A., Shealy D. and Doherty P. W. (1985) Pharmacokinetics of an indium-111-labeled monoclonal antibody in cancer patients. J. Nucl. Med. 26, 849-858.
11. 67Ga]desferrioxamine-HSA: Synthesis of chelon protein conjugates using carbodiimide as a coupling agent. Int. J. Appl. Radiat. Isot. 34, 871-877.
12. 12. Jiménez C. R., van Veelen P. A., Li K. W., Wildering W. C., Geraerts W. P. M., Tjaden U. R. and van der Greef J. (1994) Neuropeptide expression and processing as revealed by direct matrix-assisted laser desorption ionization mass spectrometry of single neurons. J. Neurochem. 62, 404-407.
13. 13. Kilbourn M. R., Dence C. S., Welch M. J. and Mathias C. J. (1987) Fluorine-18 labeling of proteins. J. Nucl. Med. 28, 462-470.
14. 67Ga-labeled antibodies using deferoxamine as a bifunctional chelate: An improved method. J. Immunol. Methods 104, 93-102.
15. 125I-labeled monoclonal antibodies in osteogenic sarcoma xenografts in nude mice. Cancer Res. 49, 1752-1757.
16. 67Ga tumor-to-blood ratios and tumor imaging. Eur. J. Nucl. Med. 7, 229-233.
17. 17. Kukis D. L., DeNardo G. L., DeNardo S. J., Mirick G. R., Miers L. A., Greiner D. P. and Meares C. F. (1995) Effect of extent of chelate substitution on the immunoreactivity and biodistribution of 2IT-BAT-Lym-1 immunoconjugates. Cancer Res. 55, 878-884.
18. 89Zr for antibody labeling and positron emission tomography. J. Label. Compds. Radiopharm. 23, 1297-1298 (Abstract).
19. 19. Maunsbach A. B. (1969) Functions of lysosomes in kidney cells. In Lysosomes in Biology and Pathology (Edited by Dingle J. T. and Fell H. B.), pp. 115-154. North Holland Publishing, Amsterdam.
20. 4N-methylthiosemicarbazone) (TSC) bifunctional chelates. J. Label. Compds. Radiopharm. 28, 877-899.
21. 21. Mealey J. (1957) Turn-over of carrier-free zirconium-89 in man. Nature 179, 673-674.
22. 22. Mease R. C., Meinken G. E., Lambert C., Steplewski Z. and Srivastava S. C. (1991) New ligands for labeling antibodies with cobalt for PET imaging. J. Nucl. Med. 32, 842 (Abstract).
23. 23. Meijs W. E., Herscheid J. D. M., Haisma H. J. and Pinedo H. M. (1992) Evaluation of desferal as a bifunctional chelating agent for labeling antibodies with Zr-89. Appl. Radiat. Isot. 43, 1443-1447.
24. 89Zr for the labelling of antibodies with a positron emitter. Appl. Radiat. Isot. 45, 1142-1147.
25. 25. Morphy J. R., Parker D. and Alexander R. (1988) Antibody labelling with functionalised cyclam macrocycles. J. Chem. Soc. Chem. Commun. 156-158.
26. 67Ga-labelled human IgG and its Fab fragments using desferoxamine as chelating agent. Eur. J. Nucl. Med. 11, 240-245.
27. 27. Motta-Hennessy C., Sharkey R. M. and Goldenberg D. M. (1990) Metabolism of indium-111-labeled murine monoclonal antibody in tumor and normal tissue of the athymic mouse. J. Nucl. Med. 31, 1510-1519.
28. 125I radiolabeled T101 anti-CD5 monoclonal antibody. Nucl. Med. Biol. 17, 201-207.
29. 67Ga-labeled human fibrinogen: A new promising thrombus imaging agent. Eur. J. Nucl. Med. 7, 458-461.
30. 111In-labeled monoclonal antibodies. Nucl. Med. Biol. 13, 325-334.
31. 31. Otsuka F. L., Welch M. J., Kilbourn M. R., Dence C. S., Dilley W. G. and Wells S. A. Jr. (1991) Antibody fragments labeled with fluorine-18 and gallium-68: In vivo comparison with indium-111 and iodine-125-labeled fragments. Nucl. Med. Biol. 18, 813-816.
32. 32. Parker D., Morphy J. R., Jankowski K. and Cox J. (1989) Implementation of macrocycle conjugated antibodies for tumour-targetting. Pure & Appl. Chem. 61, 1637-1641.
33. 33. Pimm M. V. and Gribben S. J. (1994) Prevention of renal tubule reabsorption of radiometal (indium-111) labelled Fab fragment of a monoclonal antibody in mice by systemic administration of lysine. Eur. J. Nucl. Med. 21, 663-665.
34. 34. Ryser J. E., Jones R. M. L., Egeli R., Pélegrin A., Rose K., Kurt A. M., Perin M., Broquet P. E., Ambrosetti P., Fisch I., Pochon S., Donath A., Mach J. P. and Offord R. E. (1992) Colon carcinoma immunoscintigraphy by monoclonal anti-CEA antibody labeled with gallium-67-aminooxyacetyldeferroxamine. J. Nucl. Med. 33, 1766-1773.
35. 95Nb in newborn, juvenile and adult rats. Health Phys. 22, 373-378.
36. 67Cu-labeled intact and fragmentated anti-colon carcinoma monoclonal antibody Mab35. Cancer Res. 53, 5727-5733.
37. 37. Srivastava S. C., Mausner L. F., Mease R. C., Kolsky K. L., Meinken G. E., Joshi V., Pyatt B., Wolf A. P., Schlyer D. J., Levy A. V. and Fowler J. S. (1993) Co-55-labeled monoclonal antibodies (MAbs) for tumor imaging with PET. J. Nucl. Med. 34, 237P (Abstract).
38. 38. van Gog F. B., Visser G. W. M., Klok R., van der Schors R., Snow G. B. and van Dongen G. A. M. S. (1996) Monoclonal antibodies labeled with rhenium-186 using the MAG3 chelate for clinical application: Relationship between the number of chelated groups and biodistribution characteristics. J. Nucl. Med. 37, 352-362.
39. 39. Verbeke K. A., Van Hecke W. B., Mortelmans L. A. and Verbruggen A. M. (1994) First evaluation of technetium-99m dimercaptopropionyl albumin as a possible tracer agent for ventriculography in a volunteer. Eur. J. Nucl. Med. 21, 906-912.
40. 40. Yokoyama A., Ohmomo Y., Horiuchi K., Saji H., Tanaka H., Yamamoto K., Ishii Y. and Torizuka K. (1982) Deferoxamine, a promising bifunctional chelating agent for labeling proteins with gallium: Ga-67 DF-HSA: Concise communication. J. Nucl. Med. 23, 909-914.
41. 41. Zweit J., Downey S. and Sharma H. L. (1991) Production of no-carrier-added zirconium-89 for positron emission tomography. Appl. Radiat. Isot. 42, 199-201.