Pretargeted tumour imaging with streptavidin immunoconjugates of monoclonal antibody CC49 and 111In-DTPA-biocytin

Nuclear Medicine and Biology

Volumn 23, Issue 4, 1996, Pages 459-466

  Alvarez Diez, Teresa M ^a   Polihronis, Jeannie ^a   Reilly, Raymond M ^a,b  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Biotin; Colon cancer; Monoclonal antibody CC49; Pretargeted tumour imaging; Streptavidin

Indexed keywords

BIOCYTIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CC49; PENTETATE INDIUM IN 111; STREPTAVIDIN;

ANIMAL EXPERIMENT; ARTICLE; COLON CARCINOMA; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; SCINTILLATION COUNTING; TUMOR XENOGRAFT;

EID: 0030152869     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/0969-8051(96)00022-4     Document Type: Article

References (34)

1. 1. Colcher D., Minelli M. F., Roselli M., Muraro R., Simpson-Milenic D. and Schlom, J. (1988) Radioimmunolocalization of human carcinoma xenografts with B72.3 second-generation monoclonal antibodies. Cancer Res. 48, 4597-4603.
2. 2. Del Rosario R. B. and Wahl R. L. (1989) Site-specific radiolabelling of monoclonal antibodies with biotin/streptavidin. Nucl. Med. Biol. 16, 525-529.
3. 3. Flessner M. F., Dedrick R. L. and Schultz J. S. (1985) Exchange of macromolecules between peritoneal cavity and plasma. Am. J. Physiol. 248, H15-H25.
4. 4. Gallinger S., Reilly R. M., Kirsh J. C., Odze R. D., Schmocker B. J., Hay K., Polihronis J., Damani M. T., Shpitz B. and Stern H. S. (1993) Comparative dual label study of first and second generation antitumor-associated glycoprotein-72 monoclonal antibodies in colorectal cancer patients. Cancer Res. 53, 271-278.
5. 5. Gold D. V. and Mattes M. J. (1988) Monoclonal antibody B72.3 reacts with a core region structure of O-linked carbohydrates. Tumor Biol. 9, 137-144.
6. 6. Goodwin D. A., Meares C. F., McCall M. J., McTigue M. and Chaovapong W. (1988) Pre-targeted immunoscintigraphy of murine rumors with indium-111-labelled bifunctional haptens. J. Nucl. Med. 29, 226-234.
7. 7. Hnatowich D. J., Griffin T. W., Kosciuczyk C., Rusckowski M., Childs R. L., Mattis J. A., Shealy D. and Doherty P. W. (1985) Pharmacokinetics of an indium-111-labelled monoclonal antibody in cancer patients. J. Nucl. Med. 26, 849-858.
8. 8. Kalofonos H. P., Rusckowski M., Siebecker D. A., Sivolapemko G. B., Snook D., Lavender J. P., Epenetos A. A. and Hnatowich D. J. (1990) Imaging of tumor in patients with indium-111-labelled biotin and strep-tavidin-conjugated antibodies: Preliminary communication. J. Nucl. Med. 31, 1791-1796.
9. 9. Kuijpers W. H. A., Bos E. S., Kaspersen F. M., Veeneman G. H. and van Boeckel, C. G. A. (1993) Specific recognition of antibody-oligonucleotides: A novel approach for two-step radioimmunotherapy of cancer. Bioconjug. Chem. 4, 92-102.
10. 10. Lamki L. M., Murray J. L., Rosenblum M. G., Patt Y. Z., Babaian R. and Unger M. W. (1988) Effect of unlabeled monoclonal antibody (MoAb) on biodistribution of indium-111-labelled MoAb. Nucl. Med. Commun. 9, 553-564.
11. 11. Le Doussal J-M., Chetanneau A., Gruaz-Guyon A., Martin M., Gautherot E., Lehut P.-A., Chatal J.-F., Delaage M. and Barbet J. (1993) Bispecific monoclonal antibody-mediated targeting of an indium-111-labeled DTPA dimer to primary colorectal tumors: Pharmacokinetics, biodistribution, scintigraphy and immune response. J. Nucl. Med. 34, 1662-1671.
12. 12. Lindmo T., Boven E., Cuttitta F., Fedorko J. and Bunn Jr. P. A. (1984) Determination of the immunoreactive fraction of radiolabelled monoclonal antibodies by linear extrapolation to binding at infinite antigen excess. J. Immunol. Methods 72, 77-89.
13. 99mTc monoclonal antibodies: Clinical studies. Int. J. Nucl. Med. Biol. 11, 184-188.
14. 14. Muraro R., Kuroki M., Wunderlich D., Poole D. J., Colcher D., Thor A., Greiner J. W., Simpson J. F., Molinolo A., Noguchi P. and Schlom J. (1988) Generation and characterization of B72.3 second-generation monoclonal antibodies reactive with the tumor-associated glycoprotein 72 antigen. Cancer Res. 48, 4588-4596.
15. 1311-CC49 in colorectal cancer. Cancer (Suppl.) 73, 1057-1066.
16. 111In-labeled monoclonal antibody 96.5. Cancer Res. 45, 2376-2381.
17. 17. Nagy J. A., Herzberg K. T., Masse E. M., Zientara G. P. and Dvorak H. F. (1989) Exchange of macromolecules between plasma and peritoneal cavity in ascites, tumor-bearing, normal, and seretonin-injected mice. Cancer Res. 49, 5448-5458.
18. 18. Ngai W. M. and Reilly R. M. (1993) A simple method to determine the immunoreactivity of radiolabelled monoclonal antibodies to the TAG-72 antigen. Appl. Radiat. Isot. 44, 1195-1197.
19. 19. Ngai W. M., Reilly R. M., Polihronis J. and Shpitz B. (1995) In vitro and in vivo evaluation of streptavidin immunoconjugates of the second-generation TAG-72 monoclonal antibody CC49. Nucl. Med. Biol. 22, 77-86.
20. 20. Paganelli G., Belloni C., Magnani P., Zito F., Pasini A., Sassi I., Meroni M., Mariani M., Vignali M., Siccardi A. G. and Fazio F. (1992) Two-step tumor imaging in ovarian cancer patients using biotinylated monoclonal antibodies and radioactive streptavidin. Eur. J. Nucl. Med. 19, 322-329.
21. 90Y-DOTA-biotin: Initial evaluation. J. Nucl. Med. 34, 94P (Abstract).
22. 22. Paganelli G., Magnani P., Zito F., Villa E., Sudati F., Lopalco L., Rossetti C., Malcovati M., Chiolerio F., Seccamani E., Siccardi A. G. and Fazio F. (1991b) Three-step monoclonal antibody tumor targeting in carcinoembryonic antigen-positive patients. Cancer Res, 51, 5960-5966.
23. 23. Paganelli G., Malcovati M. and Fazio F, (1991a) Monoclonal antibody pretargeting techniques for tumor localization: The avidin-biotin system. Nucl. Med. Commun. 12, 211-234.
24. 24. Patt Y. Z., Lamki L. M., Haynie T. P., Unger M. W., Rosenblum M. G., Shirkhoda A. and Murray J. L. (1988) Improved tumor localization with increasing close of indium-111-labeled anti-carci-noembryonic antigen monoclonal antibody ZCE-025 in metastatic colorectal cancer. J. Clin. Oncol. 6, 1220-1230.
25. 25. Perkins A. C., and Pimm M. V. (1991) Clinical role of immunoscintigraphy. In Immunoscintigraphy: Practical Aspects and Clinical Applications (Edited by Perkins A. C. and Pimm M. V.) pp. 129-162. New York: Wiley-Liss.
26. 26. Pimm M. V., Fells H. F., Perkins A. C. and Baldwin R. W. (1988) Iodine-131 and Indium-111 labelled avidin and streptavidin for pretargeted immunoscintigraphy with biotinylated anti-tumor monoclonal antibody. Nucl. Med. Commun. 9, 931-941.
27. 27. Reilly R. M., Sandhu J., Alvarez-Diez T. M., Gallinger S., Kirsh J. and Stern H. (1995) Problems of delivery of monoclonal antibodies: Pharmaceutical and pharmacokinetic solutions. Clin. Pharmacokinet. 28, 126-142.
28. 28. Rowlinson-Busza G., Hnatowich D. J., Rusckowki M., Snook D. and Epenetos A. A. (1993) Xenograft localization using pretargeted streptavidin-conjugated monoclonal antibody and In-111-labelled biotin. Antibody Immunoconjug. Radiopharm. 6, 97-109.
29. 29. Schechter B., Silberman R., Arnon R. M. and Wilchek M. (1990) Tissue distribution of avidin and streptavidin injected to mice: Effect of avidin carbohydrate, streptavidin truncation and exogenous biotin. Eur. J. Biochem. 189, 327-331.
30. 30. Schildt B. and Nilsson A. (1970) Standardized burns in mice. Eur. Surg. Res. 2, 23-33.
31. 90Y-labelled monoclonal antibodies for ovarian cancer: Pharmacokinetics and normal tissue dosimetry. Int. J. Cancer (Suppl.)3, 71-76.
32. 32. Thomas G. D., Chappell M. J., Dykes P. W., Ramsden D. B., Godfrey K. R., Ellis J. R. and Bradwell A. R. (1989) Effect of the dose, molecular size, affinity, and protein binding on tumor uptake of antibody or ligand: A biomathematical model. Cancer Res. 49, 3290-3296.
33. 33. Thor A., Ohuchi N., Szpak C. A., Johnston W. W. and Schlom J. (1986) Distribution of oncofetal antigen tumor-associated glycoprotein-72 defined by monoclonal antibody B72.3. Cancer Res. 46, 3118-3124.
34. 34. van Osdol W. W., Sung C., Dedrick R. L. and Weinstein J. N. (1993) A distributed pharmacokinetic model of two-step imaging and treatment protocols: Application to streptavidin-conjugated monoclonal antibodies and radiolabeled biotin. J. Nucl. Med. 34, 1552-1564.