Selection of Enterococcus faecium strains with stable and unstable resistance to the streptogramin RP 59500 using stepwise in vitro exposure

Diagnostic Microbiology and Infectious Disease

Volumn 25, Issue 1, 1996, Pages 15-20

  Millichap, John ^a   Ristow, Tracey A ^a   Noskin, Gary A ^a   Peterson, Lance R ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN MEMORIAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DALFOPRISTIN; DALFOPRISTIN PLUS QUINUPRISTIN; STREPTOGRAMIN DERIVATIVE; VANCOMYCIN;

AGAR GEL DIFFUSION; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GROWTH; CONTROLLED STUDY; ENTEROCOCCUS FAECALIS; MINIMUM INHIBITORY CONCENTRATION; PRIORITY JOURNAL; STRAIN DIFFERENCE; STREPTOCOCCUS INFECTION;

EID: 0030152388     PISSN: 07328893     EISSN: None     Source Type: Journal    
DOI: 10.1016/0732-8893(96)00067-3     Document Type: Article

References (12)

1. Andrews JM, Wise R (1994) The in vitro activity of a new semisynthetic streptogramin compound, RP 59500, against staphylococci and respiratory pathogens. J Antimicrob Chemother 33:849-853.
2. Armstrong D, Neu H, Peterson LR, Tomasz A (1995) The prospects of treatment failure in the chemotherapy of infectious diseases in the 1990s. Microbial Drug Resist 1:1-4.
3. Aumercier M, Bouhallab S, Capmau ML, LeGoffic F (1992) RP 59500: a proposed mechanism for its bactericidal activity. J Antimicrob Chemother 30(Suppl A):9-14.
4. Casewell MW, Seyed-Akhavani M, Wade J (1993) In vitro activity of RP 59500 against vancomycin-resistant Enterococcus faecium also resistant to >512 μg/ml of Gentamicin. Program Abstracts of the Interscience Conference on Antimicrobial Agents and Chemotherapy, abst. 1058.
5. Collins LA, Malanoski GJ, Eliopoulos GM, Wennersten CB, Ferraro MJ, Moellering RC Jr (1993) In vitro activity of RP 59500, an injectable streptogramin antibiotic, against vancomycin-resistant Gram-positive organisms. Antimicrob Agents Chemother 37:598-601.
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7. Etienne SD, Montay G, LeLiboux A, Frydman A, Garaud JJ (1992) A phase I-double blind, placebo-controlled study of the tolerance and pharmokinetic behaviour of RP 59500. J Antimicrob Agents Chemother 30(Suppl A):123-131.
8. Fass RJ (1991) In vitro activity of RP 59500, a semisynthetic injectable pristinamycin, against staphylococci, streptococci, and enterococci. Antimicrob Agents Chemother 35: 553-559.
9. Linden PK, Pasculle AW, Manez R, Kramer DJ, Fung JJ, Pinna AD, Kusne S (1996) Differences in outcome in patients with bacteremia due to vancomycin-resistant and vancomycin-susceptible Enterococcus faecium. Clin Infect Dis 22:663-670.
10. National Committee for Clinical Laboratory Standards (NCCLS) (1993) Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically: approved standard M7-A3. Villanova, PA: NC-CLS.
11. Peterson LR, Willard KE, Sinn LM, Fasching CE, Gerding DN (1993) GyrA sequence analysis of Staphylococcus aureus and methicillin-resistant S. aureus strains selected, in vitro, for high level ciprofloxacin resistance. Diagn Microbiol Infect Dis 17:97-101.
12. Rende-Fournier R, Leclercq R, Galimand M, Duval J, Courvalin P (1993) Identification of the sat A gene encoding a streptogramin A acetyltransferase in Enterococcus faecium BM4145. Antimicrob Agents Chemother 37:2119-2125.