Role of aspartate in ischemic spinal cord damage

Journal of Orthopaedic Research

Volumn 14, Issue 3, 1996, Pages 504-510

  Ogata, T ^a   Nakamura, Y ^a   Tsuji, K ^a   Okumura, H ^a   Kataoka, K ^a   Shibata, T ^a  

^a EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; CALCIUM; CELLS; DISEASES; MEDICAL PROBLEMS; NEUROPHYSIOLOGY;

ASPARTATE; CULTURED NEURONS; EXCITATORY NEUROTRANSMISSION; GLIAL CELLS; GLUTAMATE; HYPOXIC HYPOGLYCEMIC TREATMENT; ISCHEMIA; PATHOLOGY; SPINAL CORD DAMAGE;

AMINO ACIDS;

ASPARTIC ACID; CALCIUM ION; EXCITATORY AMINO ACID; GLUTAMIC ACID;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; EMBRYO; GLIA CELL; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY; SPINAL CORD ISCHEMIA; SPINAL CORD NERVE CELL;

EID: 0030152273     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1002/jor.1100140322     Document Type: Article

References (16)

1. 1 Balcar VJ, Borg J, Mandel P: High affinity uptake of L‐glutamate and L‐aspartate by glial cells. J Neurochem 28: 87–93, 1977
2. 2 Benveniste H, Drejer J, Schousboe A, Diemer NH: Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem 43: 1369–1374, 1984
3. 3 Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein‐dye binding. Analyt Biochem 72: 248–254, 1976
4. 4 Choi DW: Glutamate neurotoxicity in cortical cell culture is calcium dependent. Neurosci Lett 58: 293–297, 1985
5. 5 Choi DW, Viseskul V, Amirthanayagam M, Monyer H: Aspartate neurotoxicity on cultured cortical neurons. J Neurosci Res 23: 116–121, 1989
6. 6 Erecinska M, Troeger MB, Wilson DF, Silver IA: The role of glial cells in regulation of neurotransmitter amino acids in the external environment. II. Mechanism of aspartate transport. Brain Res 369: 203–214, 1986
7. 7 Kochhar A, Zivin JA, Lyden PD, Mazzarella V: Glutamate antagonist therapy reduces neurologic deficits produced by focal central nervous system ischemia. Arch Neurol 45: 148–153, 1988
8. 8 Koh JY, Choi DW: Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay. J Neurosci Methods 20: 83–90, 1987
9. 9 May cox PR, Hell JW, Jahn R: Amino acid neurotransmission: spotlight on synaptic vesicles. Trends Neurosci 13: 83–87, 1990
10. 10 Mitani A, Imon H, Iga K, Kubo H, Kataoka K: Gerbil hippocampal extracellular glutamate and neuronal activity after transient ischemia. Brain Res Bull 25: 319–324, 1990
11. 11 Ogata T, Nakamura Y, Shibata T, Kataoka K: Release of excitatory amino acids from cultured hippocampal astrocytes induced by a hypoxic‐hypoglycemic stimulation. J Neurochem 58: 1957–1959, 1992
12. 12 Ogata T, Nakamura Y, Tsuji K, Shibata T, Kataoka K: Steroid hormones protect spinal cord neurons from glutamate toxicity. Neuroscience 55: 445–449, 1993
13. 13 Ogata T, Nakamura Y, Tsuji K, Shibata T, Kataoka K, Schubert P: Adenosine enhances intracellular Ca 2+ mobilization in conjunction with metabotropic glutamate receptor activation by t‐ACPD in cultured hippocampal astrocytes. Neurosci Lett 170: 5–8, 1994
14. 14 Ozyurt E, Graham DI, Woodruff GN, McCulloch J: Protective effect of the glutamate antagonist, MK‐801 in focal cerebral ischemia in the cat. J Cereb Blood Flow Metab 8: 138–143, 1988
15. 15 Sakoda M, Hiromi K: Determination of best‐fit values of kinetic parameters of the Michaelis‐Menten equation by method of least squares with the Taylor expansion. J Biochem 80: 547–555, 1976
16. 16 Sheardown MJ, Nielsen EØ, Hansen AJ, Jacobsen P, Honore T: 2,3‐dihydroxy‐6‐nitro‐7‐sulfamoyl‐benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia. Science 247: 571–574, 1990