Generation and characterization of a human monoclonal autoantibody that acts as a high affinity interleukin-1α specific inhibitor

Molecular Immunology

Volumn 33, Issue 7-8, 1996, Pages 649-658

  Garrone, Pierre ^a   Djossou, Odile ^a   Fossiez, François ^a   Reyes, Jean ^a   Ait Yahia, Smina ^a   Maat, Corien ^a   Ho, Stephen ^a   Hauser, Thomas ^b   Dayer, Jean Michel ^b   Greffe, Jacques ^c   Miossec, Pierre ^d   Lebecque, Serge ^a   Rousset, Françoise ^a   Banchereau, Jacques ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b University Hospital ^*  (Switzerland)

^c CENTRE HOSPITALIER LE VINATIER   (France)

^d EDOUARD HERRIOT HOSPITAL   (France)

Author keywords

autoantibodies; cytokine antagonists; human monoclonal antibodies; interleukin 1

Indexed keywords

AUTOANTIBODY; CD40 ANTIGEN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY HUMAB X 3; UNCLASSIFIED DRUG;

ANTIBODY PRODUCTION; ANTIGEN BINDING; ARTICLE; B LYMPHOCYTE; CELL IMMORTALIZATION; DISSOCIATION CONSTANT; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; IMMUNOGLOBULIN VARIABLE REGION; MONONUCLEAR CELL; PRIORITY JOURNAL; SOMATIC MUTATION;

HUMAN HERPESVIRUS 4;

EID: 0030152113     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/0161-5890(96)00017-X     Document Type: Article

References (46)

1. Abrams J. S., Roncarolo M.-G., Yssel H., Andersson U., Gleich G. J. and Silver J. E. (1992) Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immun. Rev. 127, 5-24.
2. Arend W. P. (1993) Interleukin-1 receptor antagonist. Adv. Immun. 54, 167-227.
3. Banchereau J., de Paoli P., Vallé A., Garcia E. and Rousset F. (1991) Long term human B cell lines dependent on interleukin 4 and antibody to CD40. Science 251, 70-72.
4. Banchereau J. and Rousset F. (1991) Growing human B lymphocytes in the CD40 system. Nature 353, 678-679.
5. Bendtzen K. (1994) Cytokines and natural regulators of cytokines. Immun. Lett. 43, 111-123.
6. Bendtzen K., Svenson M., Jonsson V. and Hippe E. (1990) Autoantibodies to cytokines: friends or foes? Immun. Today 11, 167-169.
7. Beuscher H. U., Rausch U.-P., Otterness I. G. and Röllinghoff M. (1992) Transition from Interleukin 1β (IL-1β) to IL-1α production during maturation of inflammatory macrophages in vivo. J. exp. Med. 175, 1793-1797.
8. Bonnefoy J. Y., Denoroy M. C., Guillot O., Martens C. L. and Banchereau J. (1989) Activation of normal human B cells through their antigen receptor induces membrane expression of IL-1α and secretion of IL-1β. J. Immun. 143, 864-869.
9. Chomczynski P. and Sacchi N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Analyt. Biochem. 162, 156-159.
10. Colotta F., Re F., Muzio M., Bertini R., Polentarutti N., Sironi M., Giri J. G., Dower S. K., Sims J. E. and Mantovani A. (1993) Interleukin-1 type II receptor: as a decoy target for IL-1 that is regulated by IL-4. Science 261, 472-475.
11. Conlon P. J., Grabstein K. H., Alpert A., Prickett K. S., Hopp T. P. and Gillis S. (1987) Localization of human mononuclear cell interleukin 1. J. Immun. 139, 98-102.
12. De Mulder P. H. M., Wessels J. M. C., Rosenbrand D. A., Smeulders J.B.J.M., Wagener D. J. and Haanen C. (1981) Monocyte purification with counterflow centrifugation monitored by continuous flow cytometry. J. immunol. Meth. 47, 31-38.
13. Dechanet J., Briolay J., Rissoan M.-C., Chomarat P., Galizzi J.-P., Banchereau J. and Miossec P. (1993) Interleukin 4 inhibits growth factor-stimulated rheumatoid synoviocyte proliferation by blocking the early phases of the cell cycle. J. Immun. 151, 4908-4917.
14. Dinarello C. A. (1991) Interleukin-1 and interleukin-1 antagonism. Blood 77, 1627-1652.
15. Dinarello C. A. (1994) Is there a role for interleukin-1 blockade in intravenous immunoglobulin therapy? Immun. Rev. 139, 173-188.
16. Dinarello C. A. and Wolff S. M. (1993) The role of interleukin-1 in disease. N. Engl. J. Med. 328, 106-113.
17. Dower S. K., Fanslow W., Jacobs C., Waugh S., Sims J. E. and Widmer M. B. (1994) Interleukin-1 antagonists. Ther. Immun. 1, 113-122.
18. Elliott M. J., Maini R. N., Feldmann M., Kalden J. R., Antoni C., Smolen J. S., Leeb B., Breedveld F. C., Macfarlane J. D., Bijl H. and Woody J. N. (1994a) Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis. Lancet 344, 1105-1110.
19. Elliott M. J., Maini R. N., Feldmann M., Long-Fox A., Charles P., Bijl H. and Woody J. N. (1994b) Repeated therapy with monoclonal antibody to tumour necrosis factor α (cA2) in patients with rheumatoid arthritis. Lancet 344, 1125-1127.
20. Finkelman F. D., Madden K. B., Morris S. C., Holmes J. M., Boiani N., Katona I. M. and Maliszewski C. R. (1993) Anti-cytokine antibodies as carrier proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes. J. Immun. 151, 1235-1244.
21. Gillis S., Ferm W., Ou W. and Smith K. A. (1978) T cell growth factor: parameters of production and a quantitative micro assay for activity. J. Immun. 120, 2027-3032.
22. Guerne P.-A., Zuraw B. L., Vaughan J. H., Carson D. A. and Lotz M. (1989) Synovium as a source of interleukin 6 in vitro: contribution to local and systemic manifestations of arthritis. J. clin. Invest. 83, 585-592
23. Kabat E. A., Wu T. T., Perry H. M., Gottesman K. S. and Foeller C. (1991) In Sequences of Proteins of Immunological Interest. U.S. Dept. Health and Human Serv., National Inst. of Health, Bethesda.
24. Kurt-Jones E. A., Beller D. I., Mizel S. B. and Unanue E. R. (1985) Identification of a membrane-associated interleukin 1 in macrophages. Proc. natn. Acad. Sci. U.S.A. 82, 1204-1208.
25. Lowenthal J. W. and MacDonald H. R. (1986) Binding and internalization of interleukin 1 by T cells. Direct evidence for high-and low-affinity classes of interleukin 1 receptor. J. exp. Med. 164, 1060-1074.
26. Madec A. M., Rousset F., Ho S., Robert F., Thivolet C., Orgiazzi J. and Lebecque S. (1996) Four IgG anti-islet human monoclonal antibodies isolated from a type 1 diabetes patient recognize distinct epitopes of glutamic acid decarboxylase 65 and are somatically mutated. J. Immun. 156, 3541-3549.
27. Mae N., Liberato D. J., Chizzonite R. and Satoh H. (1991) Identification of high-affinity anti-IL-1α autoantibodies in normal human serum as an interfering substance in a sensitive enzyme-linked immunosorbent assay for IL-1α. Lymph. Cyt. Res. 10, 61-68.
28. May L. T., Neta R., Moldawer L. L., Kenney J. S., Patel K. and Sehgal P. B. (1993) Antibodies chaperone circulating IL-6. Paradoxical effects of anti-IL-6 "neutralizing" antibodies in vivo. J. Immun. 151, 3225-3236.
29. Olee T., Yang P.-M., Siminovitch K. A., Olsen N. J., Hillson J., Wu J., Kozin F., Carson D. A. and Chen P. P. (1991) Molecular basis of an autoantibody-associated restriction fragment length polymorphism that confers susceptibility to autoimmune diseases. J. clin. Invest. 88, 193-203.
30. Pech M., Jaenichen H.-R., Pohlenz H.-D., Neumaier P. S., Klobeck H.-G. and Zachau H. G. (1984) Organization and evolution of a gene cluster for human immunoglobulin variable regions of the kappa type. J. molec. Biol. 176, 189-204.
31. Peltz G. A., Trounstine M. L. and Moore K. W. (1988) Cloned and expressed human Fc receptor for IgG mediates anti-CD3 dependent lymphoproliferation. J. Immun. 141, 1891-1896.
32. Peyron E., Nicolas J. F., Réano A., Roche P., Thivolet J., Haftek M., Schmitt D., Péronne C., Banchereau J. and Rousset F. (1994) Human monoclonal autoantibodies specific for the bullous pemphigoid antigen 1 (BPAg 1). J. Immun. 153, 1333-1339.
33. Randen I., Pascual V., Victor K., Thompson K. M., Forre O., Capra J. D. and Natvig J. B. (1993) Synovial IgG rheumatoid factors show evidence of an antigen-driven immune response and a shift in the V gene repertoire compared to IgM rheumatoid factors. Eur. J. Immun. 23, 1220-1225.
34. Saurat J.-H., Schifferli J., Steiger G., Dayer J.-M. and Didierjean L. (1991) Anti-interleukin-1α autoantibodies in humans: characterization, isotype distribution, and receptor-binding inhibition. Higher frequency in Schnitzler's syndrome (urticaria and macroglobulinemia). J. Allerg. clin. Immun. 88, 244-256.
35. Scala G., Morrone G., Tamburrini M., Alfinito F., Pastore C. I., D'Alessio G. and Venuta S. (1987) Autocrine growth function of human interleukin 1 molecules on ROHA-9, an EBV-transformed human B cell line. J. Immun. 138, 2527-2534.
36. Seckinger P., Lowenthal J. W., Williamson K., Dayer J.-M. and MacDonald H. R. (1987) A urine inhibitor of interleukin 1 activity that blocks ligand binding. J. Immun. 139, 1546-1549.
37. Sims J. E., Gayle M. A., Slack J. L., Alderson M. R., Bird T. A., Giri J. G., Colotta F., Re F., Mantovani A., Shanebeck K., Grabstein K. H. and Dower S. K. (1993) Interleukin-1 signaling occurs exclusively via the type I receptor. Proc. natn. Acad. Sci. U.S.A. 90, 6155-6159.
38. Suzuki H., Ayabe T., Kamimura J. and Kashiwagi H. (1991) Anti-IL-1α autoantibodies in patients with rheumatic diseases and in healthy subjects. Clin. exp. Immun. 85, 407-412.
39. Suzuki H., Kamimura J., Ayabe T. and Kashiwagi H. (1990) Demonstration of neutralizing autoantibodies against IL-1α in sera from patients with rheumatoid arthritis. J. Immun. 145, 2140-2146.
40. Suzuki H., Takemura H., Yoshizaki K., Koishihara Y., Ohsugi Y., Okano A., Akiyama Y., Tojo T., Kishimoto T. and Kashigawi H. (1994) IL-6-anti-IL-6 autoantibody complexes with IL-6 activity in sera from some patients with systemic sclerosis. J. Immun. 152, 935-942.
41. Svenson M., Hanse M. B., Kayser L., Rasmussen A. K., Reimert C. M. and Bendtzen K. (1992) Effects of human anti-IL-1α autoantibodies on receptor binding and biological activities of IL-1. Cytokine 4, 125-133.
42. Svenson M., Hansen M. B. and Bendtzen K. (1990) Distribution and characterization of autoantibodies to interleukin 1α in normal human sera. Scand. J. Immun. 32, 695-701.
43. Svenson M., Hansen M. B. and Bendtzen K. (1993) Binding of cytokines to pharmaceutically prepared human immunoglobulin. J. clin. Invest. 92, 2533-2539.
44. Vallé A., Zuber C. E., Defrance T., Djossou O., De Rie M. and Banchereau J. (1989) Activation of human B lymphocytes through CD40 and interleukin 4. Eur. J. Immun. 19, 1463-1467.
45. Visco V., Dolecek C., Dénépoux S., Le Mao J., Guret C., Rousset F., Guinepain M. T., Kraft D., Valenta R., Wayer A., Banchereau J. and Lebecque S. (1996) Human IgG monoclonal antibodies that modulate the binding of specific IgE to birch pollen Bet v 1. J. Immun. (In press).
46. Yssel H., De Vries J. E., Koken M., Van Blitterswijk W. and Spits H. (1984) Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones. J. immunol. Meth. 72, 219-227.