Evidence for heterotrimeric GTP-binding proteins in Toxoplasma gondii

Journal of Eukaryotic Microbiology

Volumn 43, Issue 3, 1996, Pages 187-193

  Halonen, Sandra K ^a,b   Weidner, Earl ^a   Siebenaller, Joseph F ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Aluminum fluoride activation; Antibody labeling; Exocytosis; Immunocytochemical probes; Parasitophorous vacuoles; Tubule secretion

Indexed keywords

PROTOZOA; TOXOPLASMA GONDII;

ALUMINUM DERIVATIVE; ALUMINUM FLUORIDE; FLUORIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTOZOAL PROTEIN; PROTOZOON ANTIBODY;

ANIMAL; ARTICLE; CELL VACUOLE; CERCOPITHECUS; CHEMISTRY; DRUG EFFECT; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOBLOTTING; IMMUNOLOGY; RAT; TOXOPLASMA; ULTRASTRUCTURE; VERO CELL;

ALUMINUM COMPOUNDS; ANIMALS; ANTIBODIES, PROTOZOAN; CERCOPITHECUS AETHIOPS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; FLUORIDES; GTP-BINDING PROTEINS; IMMUNOBLOTTING; PROTOZOAN PROTEINS; RATS; TOXOPLASMA; VACUOLES; VERO CELLS;

EID: 0030139317     PISSN: 10665234     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1550-7408.1996.tb01389.x     Document Type: Article

References (39)

1. i3. Science, 262:1569-1572.
2. Barr, F. A., Leyte, A., Mollner, S., Pfeffer, T., Tooze, S. A. & Huttner, W. B. 1991. Trimeric G proteins of the trans-Golgi network are involved in the formation of constitutive secretory vesicles and immature secretory granules. FEBS Lett., 294:239-243.
3. Barr, F. A., Leyte, A. & Huttner, W. B. 1992. Trimeric G proteins and vesicle formation. Trends Cell Biol., 2:91-94.
4. Burgoyne, R. D., Handel, S. E. & Morgan, A. 1994. Control of exocytosis in adrenal chromaffin cells by GTP-binding proteins studied using permeabilized cells and patch-clamp capacitance measurements. Biochem. Soc. Trans., 22:468-471.
5. Cesbron-Delauw, M. F., Guy, B., Torpier, G., Pierce, R. J., Lenzen, G., Cesbron, J. Y., Charif, H., Lepage, P., Darcy, F., Lecocq, J. P. & Capron, A. 1989. Molecular characterization of a 23-kilodalton major antigen secreted by Toxoplasma gondii. Proc. Natl. Acad. Sci. USA, 86: 7537-41.
6. Charif, H., Darcy, F., Torpier, G., Cesbron-Delauw, M. F. & Capron, A. 1990. Toxoplasma gondii: characterization and localization of antigens secreted from tachyzoites. Exp. Parasit., 71:114-124.
7. iα1 and the mechanism of GTP hydrolysis. Science, 265:1405-1412.
8. i-protein from Trypanosoma cruzi epimastigote membranes. Biochemical Journal, 287:443-6.
9. Dubremetz, J. F., Achbarou, A., Bermudes, D. & Joiner, K. A. 1993. Kinetics and pattern of organelle exocytosis during Toxoplasma gondii/host-cell interaction. Parasitol. Res., 79:402-408.
10. Frenkel, J. K. 1973. Toxoplasmosis: parasite life cycle, pathology, and immunology. In: Hammond, D. M. & Long, P. L. (ed.), The Coccidea: Eimeria, Isospora, Toxoplasma and related genera. University Park Press, Baltimore. 343-410.
11. Gilman, A. G. 1987. G proteins: transducers of receptor-generated signals. Ann. Rev. Biochem., 56:615-649.
12. Goldsmith, P., Gierschik, P., Milligan, G., Unson, C. G., Vinitsky, R., Makech, H. L. & Spiegel, A. M. 1987. Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophils and brain. J. Biol. Chem., 262:14683-14688.
13. i3 complementary DNA. J. Biol. Chem., 263:6476-6479.
14. o in different tissues of vertebrates and invertebrates. Mol. Pharm., 31:313-319.
15. Joiner, K. A., Fuhrman, S. A., Mietinnen, H. A., Kasper, L. L. & Mellman, I. 1990. Toxoplasma gondii: fusion competence of parasitophorous vacuoles in Fc receptor transfected fibroblasts. Science, 249:641-646.
16. Jones, T. C., Yeh, S. & Hirsch, J. G. 1972. The interaction between Toxoplasma gondii and mammalian cells. II. The absence of lysosomal fusion with phagocytic vacuoles containing living parasites. J. Exp. Med., 136:1173-1194.
17. Kahn, R. A. 1991. Fluoride is not an activator of the smaller (20-25 kDa) GTP-binding proteins. J. Biol. Chem., 266:15595-15597.
18. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227:680-685.
19. Leriche, M. A. & Dubremetz, J. F. 1990. Exocytosis of Toxoplasma gondii dense granules into the parasitophorous vacuole after host cell invasion. Parasitol. Res., 86:1-5.
20. McKenzie, F. R., Mullaney, I., Unson, C. G., Spiegel, A. M. & Milligan, G. 1988. The use of anti-peptide antisera to probe interactions between receptors and guanine nucleotide binding proteins. Biochem. Soc. Trans., 16:434-437.
21. iα2 to the Golgi by alternative spliced carboxyl-terminal region. Science, 263:95-98.
22. Mumby, S. M., Kahn, R. A., Manning, D. R. & Gilman, A. G. 1986. Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins. Proc. Natl. Acad. Sci. USA, 83:265-269.
23. Mumby, S. M. & Gilman, A. G. 1991. Synthetic peptide antisera with determined specificity for G proteins α or β subunits. Meth. Enzymol., 195:215-253.
24. Negishi, M., Hasimoto, H. & Ichikawa, A. 1992. Translocation of α subunits of stimulatory guanine nucleotide-binding proteins through stimulation of the prostacyclin receptor in mouse mastocytoma cells. J. Biol. Chem., 267:2364-2369.
25. Oz, H. S., Huang, H., Wittner, M., Tanowitz, H. B., Bilezikian J. P. & Morris S. A. 1994. Evidence for guanosine triphosphate-binding proteins in Trypansoma cruzi. Am. J. Trop. Med.& Hyg., 50:620-31.
26. Pimplikar, S. W. & Simons, K. 1993. Role of heterotrimeric G proteins in polarized membrane transport. J. Cell Sci., Suppl., 17:27-32.
27. Sibley, L. D. 1988. Active modification of host cell phagosomes by Toxoplasma gondii. In: Moulder, J. W. (ed.), Intracellular Parasitism. CRC Press, Boca Raton. Pp. 245-257.
28. Sibley, L. D., Weidner, E. &Krahenbuhl, J.L. 1985. Phagosome acidification blocked by intracellular Toxoplasma gondii. Nature, 35: 416-419.
29. Sibley, L. D., Krahenbuhl, J. L., Adams, G. M. W. & Weidner, E. 1986. Toxoplasma modifies macrophage phagosomes by secretion of a vesicular network rich in surface proteins. J. Cell Biol., 103:867-74.
30. Sibley, L. D. & Boothroyd, J. 1991. Calcium regulated secretion and modification of host-cell endocytic compartments by Toxoplasma. J. Cell Biol., 115:5a.
31. 1 adenosine receptor modulation of adenylyl cyclase of a deep-living teleost fish, Antimora rostrata. Biol. Bull., 178:65-73
32. α C terminal antibodies. Proc. Natl. Acad. Sci. USA, 86:7809-7813.
33. Spiegel, A. M. 1990. Antibodies as probes of the structure and function of heterotrimeric GTP-binding proteins. In: Moss, J. & Vaughan, M. (ed.), ADP-Ribosylation Toxins and G-Proteins. American Society of Microbiology. Pp. 207-224.
34. αi-3, on Golgi membranes regulates the secretion of a heparan sulfate proteoglycan in LLC-PK1 epithelial cells. J. Cell Biol., 114:1113-1124.
35. Stow, J. L. & de Almeida, J. B. 1993. Distribution and role of heterotrimeric G proteins in the secretory pathway of polarized epithelial cells. J. Cell Sci., 17(suppl):33-39.
36. Tilney, L. G. & Roos, D. A. 1993. Membrane traffic and secretion in Toxoplasma gondii: a model of simplified plumbing. Mol. Biol. Cell, 4:208a.
37. o. J. Biol. Chem., 268:14715-14723.
38. Weidner, E. 1976. The microsporidian spore invasion tube. Ultrastructural isolation and characterization of the protein comprising the tube. J. Cell Biol., 71:23-24.
39. Yokoyama, S. & Starmer, W. T. 1992. Phylogeny and evolutionary rates of G protein α subunit genes. J. Mol. Evol., 35:230-238.