Interest of recombinant receptors for the testing of VIP/PACAP receptors agonists and antagonists;Intérêt des récepteurs recombinants dans l'élaboration d'agonistes et d'antagonistes des récepteurs du VIP et du PACAP

Journal de Pharmacie de Belgique

Volumn 51, Issue 3, 1996, Pages 165-169

  Robberecht, Patrick ^a,b   Gourlet, Philippe ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b Lab de Chim Biol et de la Nutr   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON; GLUCAGON LIKE PEPTIDE; GROWTH HORMONE RELEASING FACTOR; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE ANTAGONIST; CELL SURFACE RECEPTOR; HORMONE RECEPTOR; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE RECEPTOR; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE RECEPTOR 1; RECOMBINANT PROTEIN; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 1; VIPR1 PROTEIN, HUMAN;

AMINO ACID SEQUENCE; BINDING AFFINITY; CONFERENCE PAPER; ENZYME ACTIVITY; HORMONE RELEASE; PROTEIN ANALYSIS; RECEPTOR AFFINITY; RECEPTOR BINDING; ANIMAL; DRUG ANTAGONISM; DRUG POTENTIATION; GENETICS; HUMAN; MOLECULAR GENETICS; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; HUMANS; MOLECULAR SEQUENCE DATA; RECEPTORS, CELL SURFACE; RECEPTORS, PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; RECEPTORS, PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE, TYPE I; RECEPTORS, PITUITARY HORMONE; RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE; RECEPTORS, VASOACTIVE INTESTINAL POLYPEPTIDE, TYPE I; RECOMBINANT PROTEINS;

EID: 0030137835     PISSN: 00472166     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. 2 as a GRF antagonist on membranes. Endocrinology 1985, 117, 1759-1764.
2. 2 as a VIP antagonist. Endocrinology 1985, 116, 2643-2649.
3. Bissonnette, B.M., Collen, M.J., Adachi H., Jensen, R.T., Gardner, J.D. Receptors for vasoactive intestinal peptide and secretin on rat pancreatic acini. Am. J. Physiol. 1984, 246, G710-G717.
4. Dehaye J.P., Winand, J., Damien, C., Gomez, F., Poloczek, P., Robberecht, P., Vandermeers, A., Vandermeers-Piret, M.C., Stiévenart, M., Christophe, J. Receptors involved in helodermin action on rat pancreatic acini. Am. J. Physiol. 1986, 251, G602-G610.
5. Robberecht, P., Cauvin, A., Gourlet, P., Christophe, J. Heterogeneity of VIP receptors. In Pauwels, R., Lelebvre, R.A., and Herman, A.G. (Eds). Second Workshop on Nonadrenergic Noncholinergic Mechanisms, Arch. Int. Pharmacodyn. Ther. 1990, Vol. 303, pp 51-56.
6. Ishihara, T., Shigemoto, R., Mori, K., Takahashi, K., Nagata, S. Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide. Neuron 1992, 8, 811-819
7. Couvineau, A., Rouyer-Fessard, C., Darmoul, D., Maoret, J.-J., Carrero, I., Ogier-Denis, E., Laburthe, M. Human intestinal VIP receptor: Cloning and functional expression of two cDNA encoding proteins with different N-terminal domains. Biochem. Biophys. Res. Commun. 1994, 200, 769-776
8. 2 receptor: molecular characterisation of a cDNA encoding a novel receptor for vasoactive intestinal peptide. FEBS Lett. 1993, 334, 3-8.
9. Inagaki, N., Yoshida, H., Mizuta, M., Mizuno, N., Fujii, Y., Gonoi, T., Miyazaki, J.-I., Seino, S. Cloning and functional characterization of a third pituitary adenylate cyclase-activating polypeptide receptor subtype expressed in insulin-secreting cells. Proc. Watl. Acad. Sci. USA 1994, 91, 2679-2683.
10. Svoboda, M., Tastenoy, M., Ciccarelli, E., Stiévenart, M., Christophe, J. Cloning of a splice variant of the pituitary adenylate cyclase-activating polypeptide (PACAP) lype I receptor. Biochem. Biophys. Res. Commun. 1993, 195, 881-888.
11. Robberecht, P., Waelbroeck, M., De Neef, P., Tastenoy, M., Gourlet, P., Cogniaux, J., Christophe, J. A new type of functional VIP receptor has an affinity for helodermin in human SUP-T1 lymphoblasts. FEBS Lett. 1988, 228, 351-355.
12. Gourlet, P., De Neef, P., Woussen-Colle, M-C., Vandermeers, A., Vandermeers-Piret, M-C., Robberecht, P., Christophe J. The activation of adenylate cyclase by pituitary adenylale cyclase activating polypeptide (PACAP) via helodermin-preferring VIP receptors in human SUP-T1 lymphoblastic membranes. Biochim Biophys. Acta 1991, 1066, 245-251.
13. Robberecht, P., De Neef, P., Gourlet, P., Cauvin, A., Coy, D.H., Christophe, J. Pharmacological characterization of the novel helodermin/VIP receptor present in human SUP-T1 lymphoma cell membranes. Regul. Peptides 1989, 26, 117-126.
14. Usdin, T.B., Bonner, T.I., Mezey, E. Two receptors for vasoactive intestinal polypeptide with similar specificity and complementary distributions. Endocrinology 1994, 135, 2662-2680.
15. Pisegna, J.R., Wank, S.A. Molecular cloning and functional expression of the pituitary adenylate cyclase-activating polypeptide type 1 receptor. Proc. Natl. Acad. Sci. USA 1993, 90, 6345-6349.
16. Ogi, K., Miyamoto, Y., Masuda, Y., Habata, Y., Hosoya, M., Ohtaki, T., Masuo, Y., Onda, H., Fujino, M. Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor. Biochem. Biophys. Rrs. Commun. 1993, 196, 1511-1521.
17. Morrow, J.A., Lutz, E.M., West, K.M., Fink, G., Harmar, A.J. Molecular cloning and expression of a cDNA encoding a receptor for pituitary adenylate cyclase activating polypeptide (PACAP). FEBS Lett 1993, 329, 99-195.
18. Svoboda, M., Tastenoy, M., Ciccarelli, E., Stiévenart, M., Christophe, J. Cloning of a splice variant of the pituitary adenylate cyclase-activating polypeptide (PACAP) type I receptor. Biochcm. Biophys. Res. Commun. 1993, 195, 881-888.
19. Spengler, D., Waeber, C., Pantaloni, C., Holsboer, F., Bockaert, J., Seeburg, P.H., Journot, L. Differential signal transduction by five splice variants of the PACAP receptor. Nature 1993, 365, 170-175
20. Ciccarelli, E., Svoboda, M., De Neef, P., Di Paolo, E., Bollen, A., Dubeaux, C., Vilardaga, J.-P., Waelbroeck, M., Robberecht, P. Pharmacological properties of two recombinant splice variants of the PACAP type I receptor transfected and stably expressed in CHO cells. Eur. J. Pharmacol. 1995, 288, 259-267.
21. Ciccarelli, E., Vilardaga, J.-P., De Neef, P., Di Paolo, E., Waelbroeck, M., Bollen, A., Robberecht, P Properties of the VIP-PACAP type II receptor stably expressed in CHO cells. Regul. Peptides 1994, 54, 397-407.
22. Vilardaga, J.P., Ciccarelli, E., Dubeaux, C., De Neef, P., Bollen, A., Robberecht, P Properties and regulation of the coupling to adenylate cyclase of the secretin receptor stably transfected in CHO cells. Mol. Pharmacol. 1994, 45, 1022-1028.
23. Vilardaga, J.-P., De Neef, P., Di Paolo, E., Bollen, A., Waelbroeck, M., Robberecht, P. Properties of chimeric secretin and VIP receptor proteins indicate the importance of the N-terminal domain for ligand discrimination. Biochem. Biophys. Res. Commun 1995, 211, 885-891.
24. Deutsch, P.J., Sun, Y The 38-amino acid form of pituitary adenylate cyclase-activating polypeptide stimulates dual signaling cascades in PC12 cells and promotes neunte outgrowth. J. Biol. Chem. 1992, 267, 5108-5113.
25. 2+ in rat gonodotropes and somatotropes through different intracellular mechanisms. Endocrinology 1993, 132, 1447-1452.
26. 1 and inositol phosphates in human neuroblastoma NB-OK-1 cells. Peptides 1993, 14, 1111-1118.
27. Delporte, C., Poloczek, P., De Neef, P., Vertongen. P., Ciccarelli, E., Svoboda, M., Herchuelz, A., Winand, J., Robberecht, P. Pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal peptide stimulate two signaling pathways in CHO cells stably transfected with the selective type I PACAP receptor. Mol. Cell. Endocrinol. 1995, 107, 71-76.
28. s coupled receptors and dependent on receptor density. Mol. Pharmacol. 1994, 46, 460-469.