Contrast enhancement with Gd-EOB-DTPA in MR imaging of hepatocellular carcinoma in mice: A comparison with superparamagnetic iron oxide

Journal of Magnetic Resonance Imaging

Volumn 6, Issue 3, 1996, Pages 472-477

  Fujita, Makoto ^a   Yamamoto, Reiko ^a   Fritz Zieroth, Bernhard ^b   Yamanaka, Tsuyoshi ^b   Takahashi, Masaya ^a,b   Miyazawa, Tomoaki ^b   Tatsuta, Masaharu ^a,b   Terada, Nobuyuki ^a   Hosomi, Naohiro ^a   Inoue, Etsuo ^a   Kuroda, Chikazumi ^a  

^a OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

^b Nihon Schering ^*  (Japan)

Author keywords

Contrast media; Contrast media, comparative study; Liver, MR; Liver, neoplasms, MR; Magnetic resonance (MR) contrast enhancement

Indexed keywords

CONTRAST MEDIUM; DIAGNOSTIC AGENT; DRUG DERIVATIVE; GADOLINIUM ETHOXYBENZYL DTPA; GADOLINIUM PENTETATE; IRON; MAGNETITE; ORGANOMETALLIC COMPOUND; OXIDE; PENTETIC ACID;

ANIMAL; ARTICLE; C57BL MOUSE; COMPARATIVE STUDY; IMAGE ENHANCEMENT; LIVER; LIVER TUMOR; MALE; MOUSE; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; SENSITIVITY AND SPECIFICITY;

ANIMALS; CONTRAST MEDIA; FERROSOFERRIC OXIDE; GADOLINIUM DTPA; IMAGE ENHANCEMENT; IRON; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MAGNETIC RESONANCE IMAGING; MALE; MICE; MICE, INBRED C57BL; ORGANOMETALLIC COMPOUNDS; OXIDES; PENTETIC ACID; SENSITIVITY AND SPECIFICITY;

EID: 0030136980     PISSN: 10531807     EISSN: None     Source Type: Journal    
DOI: 10.1002/jmri.1880060310     Document Type: Article

References (31)

1. Itai Y, Ohtomo K, Furui S, et al. MR imaging of hepatocellular carcinoma. J Comput Assist Tomogr 1986; 10:963-968.
2. Ebara M, Ohto M, Watanabe Y, et al. Diagnosis of small hepatocellular carcinoma: correlation of MR imaging and tumor histologic studies. Radiology 1986; 159:371-377.
3. Ito K, Nishimura K, Togashi K, et al. Hepatocellular carcinoma: MR imaging. Radiology 1987; 164:21-25.
4. Kadoya M, Matsui O, Takashima T, Nonomura A. Hepatocellular carcinoma: correlation of MR imaging and histopathologic findings. Radiology 1992; 183:819-825.
5. Edelman RR, Siegel JB, Singer A, Dupuis K, Longmaid HE. Dynamic MR imaging of the liver with Gd-DTPA: initial clinical results. AJR 1989; 153:1213-1219.
6. Yoshida H, Itai Y, Ohtomo K, Kokubo T, Minami M, Yashiro N. Small hepatocellular carcinoma and cavernous hemangioma: differentiation with dynamic FLASH MR imaging with Gd-DTPA. Radiology 1989; 171:339-342.
7. Semelka RC, Shoenut JP, Kroeker MA, et al. Focal liver disease: comparison of dynamic gadolinium-enhanced MR imaging at 1.5 T. Radiology 1992; 184:687-694.
8. Saini S, Stark DD, Hahn PF, Wittenberg J, Brady TJ, Ferrucci JT. Ferrite particles: a superparamagnetic MR contrast agent for the reticuloendothelial system. Radiology 1987; 162:211-216.
9. Stark DD, Weissleder R, Elizondo G, et al. Superparamagnetic iron oxide: clinical application as a contrast agent for MR imaging of the liver. Radiology 1988; 168:297-301.
10. Marchal G. Van Hecke P, Demaerel P, et al. Detection of liver metastases with superparamagnetic iron oxide in 15 patients: results of MR imaging at 1.5 T. AJR 1989; 152:771-775.
11. Fretz CJ, Elizondo G, Weissleder R, Hahn PF, Stark DD, Ferrucci JT. Superparamagnetic iron oxide-enhanced MR imaging: pulse sequence optimization for detection of liver cancer. Radiology 1989; 172:393-372.
12. Ferrucci JT, Stark DD. Iron oxide-enhanced MR imaging of the liver and spleen; review of the first 5 years. AJR 1990; 155:943-950.
13. Bellin MF, Zaim S, Auberton E, et al. Liver metastases: safety and efficacy of detection with superparamagnetic iron oxide in MR imaging. Radiology 1994; 193:657-663.
14. Duda SH, Laniado M, Kopp AF, et al. Superparamagnetic iron oxide: detection of focal liver lesions at high-field-strength MR imaging. JMRI 1994; 4:309-314.
15. Hamm B, Staks T, Taupitz M, et al. Contrast-enhanced MR imaging of liver and spleen: first experience in humans with a new superparamagnetic iron oxide. JMRI 1994; 4:659-668.
16. Shtern F, Garrido L, Compton C, Swiniarsky JK, Lauffer R, Brady TJ. MR imaging of blood-borne liver metastases in mice: contrast enhancement with Fe-EHPG. Radiology 1991; 178:83-89.
17. Hamm B, Vogl TJ, Branding G, et al. Focal liver lesions: MR imaging with Mn-DPDP - initial clinical results in 40 patients. Radiology 1992; 182:167-174.
18. Aicher KP, Laniado M, Kopp AF, Groenewaeller E, Duda SH, Claussen CD. Mn-DPDP-enhanced MR imaging of malignant liver lesions: efficacy and safty in 20 patients. JMRI 1993; 3: 731-737.
19. Schuhmann-Giampieri G, Schmitt-Willich H, Press WR, Negishi C, Weinmann HJ, Speck U. Preclinical evaluation of Gd-EOB-DTPA as a contrast agent in MR imaging of the hepatobiliary system. Radiology 1992; 183:59-64.
20. Clément O, Mühler A, Vexler V, Berthezène Y, Brasch RC. Gadolinium-ethoxybenzyl-DTPA, a new liver-specific magnetic resonance contrast agent: kinetic and enhancement patterns in normal and cholestatic rats. Invest Radiol 1992; 27:612-619.
21. Mühler A, Clément O, Vexler V, Berthezène Y, Rosenau W, Brasch RC. Hepatobiliary enhancement with Gd-EOB-DTPA: comparison of spin-echo and STIR imaging for detection of experimental liver metastases. Radiology 1992; 184:207-213.
22. Marchal G, Zhang X, Ni Y, Van Hecke P, Yu J, Baert AL. Comparison between Gd-DTPA, Gd-EOB-DTPA, and Mn-DPDP in induced HCC in rats: a correlation study of MR imaging, microangiography, and histology. Magn Reson Imaging 1993; 11:665-674.
23. Ni Y, Marchak G, Yu J, Mühler A, Lukito G, Baert AL. Prolonged positive contrast enhancement with Gd-EOB-DTPA in experimental liver tumors: potential value in tissue characterization. JMRI 1994; 4:355-363.
24. Yamamoto R, Iishi H, Tatsuta M, Tsuji M, Terada N. Roles of ovaries and testes in hepatocellular tumorigenesis induced in mice by 3′-methyl-4-dimethylaminoazobenzene. Int J Cancer 1991; 49:83-88.
25. Kawamori Y, Matsui O, Kadoya M, Yoshikawa J, Demachi H, Takashima T. Differentiation of hepatocellular carcinomas from hyperplastic nodules induced in rat liver with ferrite-enhanced MR imaging. Radiology 1992; 183:65-72.
26. Edmondson HA, Steiner PE. Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer 1954; 7: 462-503.
27. Vesselinovitch SD, Mihailovitch N, Rao KVN. Morphology and metastatic nature of induced hepatic nodular lesions in C57BLXC3H-F1 mice. Cancer Res 1978; 38:2003-2010.
28. Muramatsu Y, Nawano S, Takayasu K, et al. Early hepatocellular carcinoma: MR imaging. Radiology 1991; 181:209-213.
29. Hacker HJ, Mtiro H, Bannasch P, Vesselinovitch SD. Histochemical profile of mouse hepatocellular adenomas and carcinomas induced by a single dose of diethylnitrosamine. Cancer Res 1991; 51:1952-1958.
30. Mühler A, Staks T, Frenzel T, Vogler H, Lange L, Weinmann HJ. First use of the hepatobiliary MR contrast agent Gd-EOB-DTPA in man (abstract). In: Book of Abstracts: Society of Magnetic Resonance in Medicine. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1994; 894.
31. Ni Y, Marchal G, Lukito G, Yu J, Mühler A, Baert AL. MR imaging evaluation of enhancement by Gd-EOB-DTPA in selective and total bile duct obstruction in rats: correlation with serologic, microcholangiographic, and histologic findings. Radiology 1994; 190:753-758.