Stimulation of phosphoinositide hydrolysis by γ- and δ- hexachlorocyclohexane in primary cultures of cerebellar granule cells: Interaction with glutamate and carbachol receptor-mediated phosphoinositide response and effects of specific pharmacological agents

Pesticide Biochemistry and Physiology

Volumn 55, Issue 1, 1996, Pages 64-76

  Sanfeliu, Coral ^a   Rosa, Roser ^a   Suñol, Cristina ^a   Rodríguez Farré, Eduard ^a   Cristòfol, Rosa M ^a  

^a CSIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0030136482     PISSN: 00483575     EISSN: None     Source Type: Journal    
DOI: 10.1006/pest.1996.0036     Document Type: Article

References (54)

1. 1. M. J. Berridge, Inositol triphosphate and diacylglicerol: Two interacting second messengers, Annu. Rev. Biochem. 56, 159 (1987).
2. 2. M. J. Berridge and R. F. Irvine, Inositol phosphates and cell signalling, Nature 341, 197 (1989).
3. 3. M. J. Berridge, Inositol triphosphate and calcium signalling, Nature 361, 315 (1993).
4. 4. S. K. Fisher, A. M. Heacock, and B. W. Agranoff, Inositol lipids and signal transduction in the nervous system: An update, J. Neurochem. 58, 18 (1992).
5. 5. E. Claro, A. García, and F. Picatoste, Carbachol and histamine stimulation of guanine-nucleotide-dependent phosphoinositide hydrolysis in rat brain cortical membranes, Biochem. J. 261, 29 (1989).
6. 2+ activates phospholipase C, Trends Neurosci. 11, 517 (1988).
7. 7. L. G. Costa, The phosphoinositide/protein kinase C system as a potential target for neurotoxicity, Pharmacol. Res. 22, 393 (1990).
8. 8. B. McNamara and S. Krop, Observations on the pharmacology of the isomers of hexachlorocyclohexane, J. Pharmacol. Exp. Ther. 92, 140 (1948).
9. 9. H. W. Vohland, J. Portig, and K. Stein, Neuropharmacological effects of isomers of hexachlorocyclohexane, 1. Protection against pentylenetetrazol-induced convulsions, Toxicol. Appl. Pharmacol. 57, 425 (1981).
10. 10. L. J. Lawrence and J. E. Casida, Interaction of lindane, toxaphene, and cyclodienes with brain specific t-butylbicyclophosphorothionate receptor, Life Sci. 35, 171 (1984).
11. 11. F. Matsumura, Involvement of picrotoxinin receptor in the action of cyclodiene insecticides, Neurotoxicology 6, 139 (1985).
12. 12. A. Pomés, E. Rodríguez-Farré, and C. Suñol, Disruption of GABA-dependent chloride flux by cyclodienes and hexachlorocyclohexanes in primary cultures of cortical neurons, J. Pharmacol. Exp. Ther. 271, 1616 (1994).
13. 35S]t-butylbicyclophosphorothionate to Torpedo electric organ membranes and stereospecificity of the binding site, Toxicol. Appl. Pharmacol. 95, 220 (1988).
14. 14. R. G. Thompson, D. E. Menking, and L. L. Valdes, Comparison of lindane, bicyclophosphate and picrotoxin binding to the putative chloride channel sites in rat brain and Torpedo electric organ, Neurotoxicol. Teratol. 12, 57 (1990).
15. 15. M. Vendrell, M. J. Pujol, J. M. Tusell, and J. Serratosa, Effect of different convulsants on calmodulin levels and proto-oncogene c-fos expression in the central nervous system, Mol. Brain Res. 14, 285 (1992).
16. 16. J. M. Tusell, S. Barrón, and J. Serratosa, Anticonvuĺ sant activity of δ-HCH, calcium channel blockers and calmodulin antagonists in seizures induced by lindane and other convulsant drugs, Brain Res. 622, 99 (1993).
17. 17. S. C. Bondy and L. Halsall, Lindane-induced modulation of calcium levels within synaptosomes, Neurotoxicology 9, 645 (1988).
18. 18. R. M. Joy and V. W. Burns, Exposure to lindane and two other hexachlorocyclohexane isomers increases free intracellular calcium levels in neurohybridoma cells, Neurotoxicology 9, 637 (1988).
19. 19. I. N. Pessah, F. C. Mohr, M. Schiedt, and R. M. Joy, Stereoselective modulation of ryanodine-sensitive calcium channels by the δ isomer of hexachlorocyclohexane (δ-HCH), J. Pharmacol. Exp. Ther. 262, 661 (1992).
20. 20. G. M. Omann and J. R. Lakowicz, Interactions of chlorinated hydrocarbon insecticides with membranes, Biochem. Biophys. Acta 684, 83 (1982).
21. 21. S. P. Verma and A. Rastogi, Organic pesticides modify lipid-lipid domains in model membranes. A laser Raman study, Biochim. Biophys. Acta 1027, 59 (1990).
22. 22. I. Carrero, J. C. Prieto, M. N. Recio, N. del Hoyo, and M. A. Perez-Albarsanz, The diverse actions of lindane in rat enterocytes: Interactions with lipid metabolism and membrane fluidity, Pestic. Biochem. Physiol. 47, 69 (1993).
23. 23. J. S. Kang and I. Yun, Effects of lindane on microviscosity of brain membranes, Asia Pacific J. Pharmacol. 9, 67 (1994).
24. 24. R. M. Cristòfol, E. Rodríguez-Farré, and C. Sanfeliu, Effects of γ and δ hexachlorocyclohexane isomers on inositol phosphate formation in cerebral cortex and hippocampus slices from developing and adult rat, Neurotoxicology 14, 451 (1993).
25. 25. S. Senar, M. N. Recio, and M. A. Pérez-Albarsanz, Lindane affects phosphoinositide hydrolysis through a different mechanism of the phosphatidylinositol synthesis inhibition in rat renal tubule cell culture, Cell. Signalling 6, 433 (1994).
26. 26. N. del Hoyo, J. A. Pulido, and M. A. Pérez-Albarsanz, Characterization of phosphoinositide hydrolysis products induced by hexachlorocyclohexane isomers in rat brain cortex, Biosci. Reports 13, 119 (1993).
27. 27. J. Xu and D.-M. Chuang, Muscarinic acetylcholine receptor-mediated phosphoinositide turnover in cultured cerebellar granule cells: Desensitization by receptor agonists, J. Pharmacol. Exp. Ther. 242, 238 (1987).
28. 28. E. M. Whitham, R. A. J. Challis, and S. R. Nahorski, M3 muscarinic cholinoreceptors are linked to phosphoinositide metabolism in rat cerebellar granule cells, Eur. J. Pharmacol. Mol. Pharmacol. 206, 181 (1991).
29. 29. F. Nicoletti, J. T. Wroblewski, A. Novelli, H. Alho, A. Guidotti, and E. Costa, The activation of inositol phospholipid metabolism as a signal-transducing system for excitatory amino acids in primary cultures of cerebellar granule cells, J. Neurosci. 6, 1905 (1986).
30. 30. E. Aronica, F. Nicoletti, D. F. Condorelli, and R. Balázs, Pharmacological characterization of metabotropic glutamate receptors in cultured cerebellar granule cells, Neurochem. Res. 18, 605 (1993).
31. 31. A. Schousboe, E. Meier, J. Drejer, and L. Hertz, Preparation of primary cultures of mouse (rat) cerebellar granule cells, in "A Dissection and Tissue Culture Manual of the Nervous System" (A. Shahar, J. De Vellis, A. Vernadakis and B. Haber, Eds.), p. 203, Alan R. Liss, New York, 1989.
32. 32. M. J. Berridge, C. P. Downes, and M. R. Hanley, Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands, Biochem. J. 206, 587 (1982).
33. 33. C. P. Downes, P. T. Hawkins, and R. F. Irvine, Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-biphosphate is the probable precursor of inositol 1,3,4-triphosphate in agonist-stimulated parotid gland, Biochem. J. 238, 501 (1986).
34. + stimulation in cultured cerebellar granule cells, Brain Res. 623, 155 (1993).
35. 35. J. D. Macklis and R. D. Madison, Progressive incorporation of propidium iodide in cultured mouse neurons correlates with declining electrophysiological status: A fluorescence scale of membrane integrity, J. Neurosci. Methods 31, 43 (1990).
36. 36. B. H. J. Juurlink and L. Hertz, Ischemia-induced death of astrocytes and neurons in primary culture: Pitfalls in quantifying neuronal cell death, Dev. Brain Res. 71, 239 (1993).
37. 37. A. L. Nieminen, G. J. Gores, J. M. Bond, R. Imberti, B. Herman, and J. J. Lemasters, A novel cytotoxicity screening assay using a multiwell fluorescence scanner, Toxicol. Appl. Pharmacol. 115, 147 (1992).
38. 38. M. Vignes, J. Guiramand, I. Sassetti, and M. Récasens, Dithiothreitol specifically inhibit metabotropic responses of glutamate and depolarizing agents in rat brain synaptoneurosomes, Neurochem. Int. 21, 229 (1992).
39. 39. D. D. Schoepp, B. G. Johnson, E. C. R. Smith, and L. A. McQuaid, Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid, Mol. Pharmacol. 38, 222 (1990).
40. 40. D. D. Schoepp and P. J. Con, Metabotropic glutamate receptors in brain function and pathology, Trends Pharmacol. Sci. 14, 13 (1993).
41. 41. D. A. Kendall and S. R. Nahorski, Inositol phospholipid hydrolysis in rat cerebral cortical slices: II. Calcium requirement, J. Neurochem. 42, 1388 (1984).
42. 42. J. Guiramand, M. Vignes, and M. Récasens, A specific transduction mechanism for the glutamate action on phosphoinositide metabolism via the quisqualate metabotropic receptor in rat brain synaptoneurosomes: II. Calcium dependency, cadmium inhibition, J. Neurochem. 57, 1501 (1991).
43. 43. J. Patel, R. A. Keith, A. I. Salama, and W. C. Moore, Role of calcium in regulation of phosphoinositide signaling pathway, J. Mol. Neurosci. 3, 19 (1991).
44. 44. R. Raulli, W. Danysz, and J. T. Wroblenski, Pretreatment of cerebellar granule cells with concanavalin A potentiates quisqualate-stimulated phosphoinositide hydrolysis, J. Neurochem. 56, 2116 (1991).
45. 45. M. Benuck, M. E. A. Reith, and A. Lajtha, Phosphoinositide hydrolysis induced by depolarization and sodium channel activation in mouse cerebrocortical slices, Neuropharmacology 28, 847 (1989).
46. 46. R. Rosa, E. Rodríguez Farré, and C. Sanfeliu, Cytotoxicity of hexachlorocyclohexane isomers and cyclodienes in prymary cultures of cerebellar granule cells. J. Pharmacol. Exp. Ther., in press.
47. + depolarization on inositol polyphosphate production in rat cerebral cortex, J. Neurochem. 53, 681 (1989).
48. 2+ entry in rat basophilic leukemia cells, Mol. Pharmacol. 48, 512 (1995).
49. 49. R. A. J. Challis, R. Mistry, D. W. Gray, and S. R. Nahorski, Modulatory effects of NMDA on phosphoinositide responses evoked by the metabotropic glutamate receptor agonist 1S,3R-ACPD in neonatal rat cerebral cortex, Br. J. Pharmacol. 112, 231 (1994).
50. 50. R. A. J. Challis, R. Mistry, D. W. Gray, and S. R. Nahorski, Modulation of muscarinic cholinoceptor-stimulated inositol 1,4,5-trisphosphate accumulation by N-methyl-D-aspartate in neonatal cerebral cortex, Neuropharmacology 33, 15 (1994).
51. 51. W.-W. Lin, C. Y. Lee, T. Yasumoto, and D-M. Chuang, Maitotoxin induces phosphoinositide turnover and modulates glutamatergic and muscarinic cholinergic receptor function in cultured cerebellar neurons, J. Neurochem. 55, 1563 (1990).
52. 2+ influx, γ-hexachlorocyclohexane, Biochem. Biophys. Res. Commun. 199, 699 (1994).
53. 53. G. S. Parries and M. Hokin-Neaverson, Inhibition of phosphatidylinositol synthase and other membrane-associated enzymes by stereoisomers of hexachlorocyclohexane, J. Biol. Chem. 260, 2687 (1985).
54. 54. D. Agrawal, A. Subramoniam, and F. Afad, Influence of hexachlorocyclohexane on phosphoinositides in rat erythrocyte membranes and brain, Toxicology 95, 135 (1995).