Architectural flexibility in lambda site-specific recombination: Three alternate conformations channel the attL site into three distinct pathways

Genes to Cells

Volumn 1, Issue 5, 1996, Pages 453-463

  Segall, Anca M ^a,b   Nash, Howard A ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b SAN DIEGO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; BACTERIOPHAGE RECEPTOR; INTEGRASE; VIRUS DNA;

ARTICLE; BACTERIOPHAGE LAMBDA; CHEMISTRY; CONFORMATION; ENZYME SPECIFICITY; GENETIC RECOMBINATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; PHENOTYPE;

ATTACHMENT SITES, MICROBIOLOGICAL; BACTERIOPHAGE LAMBDA; BASE SEQUENCE; DNA, BACTERIAL; DNA, VIRAL; INTEGRASES; MUTATION; NUCLEIC ACID CONFORMATION; PHENOTYPE; RECOMBINATION, GENETIC; SUBSTRATE SPECIFICITY;

EID: 0030133847     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.1996.d01-254.x     Document Type: Article

References (5)

1. Burgin, Jr., A.D. & Nash, H.A. (1995) Suicide substrates reveal properties of the homology-dependent steps during integrative recombination of bacteriophage λ. Curr. Biol. 5, 1312-1321.
2. Colicelli, J. & Goff, S.P. (1988) Sequence and spacing requirements of a retrovirus integration site. J. Mol. Biol. 199, 47-59.
3. Echols, H. (1970) Integrative and excisive recombination by bacteriophage 1: Evidence for an excision-specific recombination protein. J. Mol. Biol. 47, 575-583.
4. Enquist, L.W. & Weisberg, R.A. (1984) An integration-proficient int mutant of bacteriophage lambda. Mol. Gen. Genet. 195, 62-69.
5. Goodman, S.D., Nicholson, S.C. & Nash, H.A. (1992) Deformation of DNA during site-specific recombination of bacteriophage lambda: replacement of IHF protein by HU protein or sequence-directed bends. Proc. Natl. Acad. Sci. USA 89, 11910-11914.