Sepsis increases putrescine concentration and protein synthesis in mucosa of small intestine in rats

Shock

Volumn 5, Issue 5, 1996, Pages 333-340

  Noguchi, Yoshifumi ^b   Meyer, Tory ^b   Tiao, Greg ^a   Fischer, Josef E ^a   Hasselgren, Per Olof ^a  

^a UNIVERSITY OF CINCINNATI   (United States)

^b SHRINERS HOSPITALS FOR CHILDREN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EFLORNITHINE; ENZYME INHIBITOR; ORNITHINE DECARBOXYLASE; PUTRESCINE;

ANIMAL; ARTICLE; CELL CULTURE; DRUG ANTAGONISM; MALE; METABOLISM; PATHOPHYSIOLOGY; PROTEIN SYNTHESIS; RAT; SEPSIS; SMALL INTESTINE; SPRAGUE DAWLEY RAT;

ANIMALS; CELLS, CULTURED; EFLORNITHINE; ENZYME INHIBITORS; INTESTINE, SMALL; MALE; ORNITHINE DECARBOXYLASE; PROTEIN BIOSYNTHESIS; PUTRESCINE; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS;

EID: 0030133348     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-199605000-00004     Document Type: Article

References (31)

1. Wilmore DW, Smith RJ, Sarah T, O'Dwyer ST, Jacobs DO, Ziegler TR, Wang XD: The gut: A central organ after surgical stress. Surgery 104: 917-923, 1988.
2. von Allmen D, Hasselgren PO, Higashiguchi T, Frederick J. Zamir O, Fischer JE: Increased intestinal protein synthesis during sepsis and following the administration of tumor necrosis factor α or interleukin-α. Biochem J 286:585-589, 1992.
3. Higashiguchi T, Noguchi Y. O'Brien W, Wagner K, Fischer JE, Hasselgren PO: Effect of sepsis on mucosal protein synthesis in different parts of the gastrointestinal tract in rats. Clin Sci 87:207-211, 1994.
4. Yoshida S, Leskiw MJ, Schluter MD, et al: Effect of total parenteral nutrition, systemic sepsis, and glutamine on gut mucosa in rats. Am J Physiol 263:E368-E373, 1992.
5. Higashiguchi T, Noguchi Y, Meyer T, Fischer JE, Hasselgren PO: Protein synthesis in isolated enterocytes from septic or endotoxemic rats: Regulation by glutamine. Clin Sci 89:311-319, 1995.
6. McNurlan MA, Tomkins AM, Garlick PJ: The effect of starvation on the rate of protein synthesis in rat liver and small intestine. Biochem J 178:373-379, 1979.
7. Meyer T, Wang JJ, Tiao CM, Ogle CK, Fischer JE, Hasselgren PO: Sepsis and endotoxemia stimulate intestinal interleukin-6 production. Surgery 118:336-342, 1995.
8. Pegg AE: Recent advances in the biochemistry of polyamines in eukaryotes. Biochem J 234:249-262, 1986.
9. McCormack SA, Johnson LR: Role of polyamines in gastrointestinal mucosal growth. Am J Physiol 260:G795-G806, 1991.
10. Noguchi Y. Meyer TA, Tiao G, Ogle CK, Fischer JE, Hasselgren PO: Influence of sepsis and endotoxemia on polyamine metabolism in mucosa of small intestine in rats: Metabolism 45:28-33, 1996.
11. Metcalf BW, Bey P, Danzin C, Jung MJ, Casara P, Vevert JP: Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C. 4.1.1.17) by substrate and product analogs. J Am Chem Soc 100:2551-2553, 1978.
12. Rafferty JF, Noguchi Y, Fischer JE, Hasselgren PO: Sepsis in rats stimulates cellular proliferation in mucosa of small intestine. Gastroenterology 107:121-127, 1994.
13. Pedersen PV, Warner BW, Bjornson HS, et al: Hemodynamic and metabolic alterations during experimental sepsis in young and adult rats. Surg Gynecol Obstet 168:148-156, 1989.
14. Wang JY, Johnson LR: Induction of gastric and duodenal mucosal ornithine decarboxylase during stress. Am J Physiol 257:G259-G265, 1989.
15. Wang JY, Johnson LR: Role of ornithine decarboxylase in repair of gastric mucosal stress ulcers. Am J Physiol 258:G78-G85, 1990.
16. Watford M, Lund P, Krebs HA: Isolation and metabolic characteristics of rat and chicken enterocytes. Biochem J 178:589-596, 1979.
17. Higashiguchi T, Hasselgren PO, Wagner K, Fischer JE: Effect of glutamine on protein synthesis in isolated intestinal epithelial cells. J Parenter Enterai Nutr 17:307-314, 1993.
18. Fujimoto K, Granger DN, Price VH, Tso P: Ornithine decarboxylase is involved in repair of small intestine after ischemia-reperfusion in rats. Am J Physiol 261:G523-G529, 1991.
19. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275, 1951.
20. Wang JY, Viar MJ, McCormack SA, Johnson LR: Effect of putrescine on S-adenosyl-methionine decarboxylase in small intestinal crypt cell line. Am J Physiol 263:G494-G501, 1992.
21. Wang JY, Johnson LR, Tsai YH, Castro GA: Mucosal ornithine decarboxylase, polyamines, and hyperplasia in infected intestine. Am J Physiol 260:G45-051, 1991.
22. Bucher NLR, Swaffield MN: Ribonucleic acid synthesis in relation to precursor pools in regenerating rat liver. Biochem Biophys Acta 174:491-502, 1969.
23. Chung DH, Evers BM, Townsend CM, et al: Cytokine regulation of gut ornithine decarboxylase gene expression and enzyme activity. Surgery 112:364-369, 1992.
24. Ko TC, Beauchamp RD, Townsend CM, Thompson JC: Glutamine is essential for epidermal growth factor-stimulated intestinal cell proliferation. Surgery 114:147-154, 1993.
25. Fitzpatrick LR, Wang P, Eikenburg BE, Haddox MK, Johnson LR: Effect of refeeding on polyamine biosynthesis in isolated enterocytes. Am J Physiol 250:G709-G713, 1986.
26. Halline AG, Dudeja PK, Brasitus TA: Differential stimulation of S-adenosylmethionine decarboxylase by difluoromethylornithine in the rat colon, small intestine: Biochem J 259:513-518, 1989.
27. Mamont PS, Danzin C: In vitro and in vivo regulation of S-adenosyl-L-methionine decarboxylase by polyamines. Adv Polyamine Res 3:123-135, 1981.
28. Wang JY, McCormack SA, Viar MJ, Johnson LR: Stimulation of proximal small intestinal mucosal growth by luminal polyamines. Am J Physiol 261:G504-G511, 1991.
29. McCormack SA, Johnson LR: Putrescine uptake and release by a normal rat small intestine crypt cell line, IEC-6. Exp Cell Res 193:241-252, 1991.
30. Ginty DD, Osborne DL, Seidel ER: Putrescine stimulates DNA synthesis in intestinal epithelial cells. Am J Physiol 257:G145-G150, 1989.
31. Guzman C, MacLeod RJ, Hamilton JR: Failure of ornithine decarboxylase inhibition to alter small intestinal epithelial repair after transient segmental ischemia. Gut 29:935-940, 1988.