Long-term interferon-α treatment of children with chronic hepatitis delta: A multicentre study

Journal of Viral Hepatitis

Volumn 3, Issue 3, 1996, Pages 123-128

  Di Marco, V ^a,o   Giacchino, R ^b   Timitilli, A ^b   Bortolotti, F ^c   Crivellaro, C ^d   Calzia, R ^e   Iannuzzi, C ^f   Prestileo, T ^g   Vajro, P ^h   Nebbia, G ⁱ   Stringhi, C ^j   Rosina, F ^k   Biassoni, D ^l   Callea, F ^m   Rizzetto, M ⁿ   Craxi, A ^a  

^a UNIVERSITY OF PALERMO   (Italy)

^b G GASLINI INSTITUTE   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

^d Division Malattie Infettive   (Italy)

^e UNIVERSITY OF GENOA   (Italy)

^f II Clinica Malattie Infettive   (Italy)

^g Divisione Malattie Infettive   (Italy)

^h UNIVERSITY OF NAPLES FEDERICO II   (Italy)

ⁱ Clinica Pediatrica De Marchi   (Italy)

^j OSPEDALE NIGUARDA CA GRANDA   (Italy)

^k MOLINETTE HOSPITAL   (Italy)

^l Biology Research   (Italy)

^m OSPEDALI RIUNITI   (Italy)

ⁿ Dipartimento di Medicina Interna   (Italy)

^o VILLA SOFIA CERVELLO HOSPITAL   (Italy)

more..

Author keywords

Children; Chronic hepatitis D; Interferon

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA INTERFERON; ANTIVIRUS AGENT; HEPATITIS B(E) ANTIGEN; RECOMBINANT INTERFERON; VIRUS ANTIGEN; VIRUS DNA; VIRUS RNA;

ADOLESCENT; ARTICLE; BLOOD; CHILD; CHRONIC DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DELTA AGENT HEPATITIS; FEMALE; GENETICS; HEPATITIS B VIRUS; HEPATITIS DELTA VIRUS; HUMAN; IMMUNOLOGY; MALE; MULTICENTER STUDY; PATIENT COMPLIANCE;

ADOLESCENT; ALANINE TRANSAMINASE; ANTIGENS, VIRAL; ANTIVIRAL AGENTS; CHILD; CHRONIC DISEASE; DNA, VIRAL; FEMALE; HEPATITIS B E ANTIGENS; HEPATITIS B VIRUS; HEPATITIS D; HEPATITIS DELTA VIRUS; HUMANS; INTERFERON TYPE I, RECOMBINANT; INTERFERON-ALPHA; MALE; PATIENT COMPLIANCE; RNA, VIRAL;

EID: 0030133134     PISSN: 13520504     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2893.1996.tb00002.x     Document Type: Article

References (30)

1. Rizzetto M, Verme G, Recchia S et al. Chronic HBsAg hepatitis with intrahepatic expression of delta antigen. An active and progressive disease unresponsive to immunosuppressive treatment. Ann Intern Med 1983; 98: 437-441.
2. Sagnelli E, Stroffolini T, Ascione A et al. The epidemiology of hepatitis delta infection in Italy. J Hepatol 1992; 15: 211-215.
3. Hadziyannis SJ, Dourakis SP, Papaioannou C, Alexopoulou A, Hadziyannis ES, Gioustozi A. Changing epidemiology and spreading modalities of hepatitis delta virus infection in Greece. Prog Clin Biol Res 1993; 382: 259-266.
4. Bonino F, Caporaso N, Dentico P et al. Familiar clustering and spreading of hepatitis delta virus infection. J Hepatol 1985; 1: 221-226.
5. Craxì A, Tinè F, Vinci M et al. Transmission of hepatitis B and hepatitis delta viruses in the households of chronic hepatitis B surface antigen carriers: A regression analysis of indicators of risk. Am J Epidemiol 1991; 134: 641-650.
6. Bortolotti F, Calzia F, Vegnente A et al. Chronic hepatitis in childhood: the spectrum of the disease. Gut 1988; 29: 659-664.
7. Farci P, Barbera C, Navone C et al. Infection with the delta agent in children. Gut 1985; 26: 2-7.
8. Maggiore G, Hadchouel M, Sessa F et al. A retrospective study of the role of delta agent infection in children with HBsAg-positive chronic hepatitis. Hepatology 1985; 5: 7-9.
9. Rizzetto M, Ponzetto A. Epidemiology of hepatitis delta virus: overview. Prog Clin Biol Res 1991; 364: 1-20.
10. Bortolotti F, Di Marco V, Vajro P et al. Long-term evolution of chronic delta hepatitis in children. J Pediatr 1993; 122: 736-739.
11. Rosina F, Pintus C, Meschievitz C, Rizzetto M. A randomized controlled trial of a 12-month course of recombinant human interferon-alfa in chronic delta (type D) hepatitis: A multicenter Italian study. Hepatology 1991; 13: 1052-1056.
12. Farci P, Mandas A, Coiana A et al. Treatment of chronic hepatitis D with interferon alfa-2a. N Engl J Med 1994; 330: 88-94.
13. Gaudin J-L, Faure P, Godinot H, Trepo C. The French experience of treatment of chronic type D hepatitis with a 12-month course of interferon alpha-2B. Results of a randomized controlled trial. Liver 1995; 15: 45-52.
14. Gowans EJ, Bonino F. Hepatitis delta virus pathogenicity. Prog Clin Biol Res 1993; 382: 125-130.
15. Colombo P, Di Blasi F, Magrin S et al. Smouldering hepatitis B virus replication in patients with chronic liver disease and hepatitis delta virus superinfection. J Hepatol 1991; 12: 64-69.
16. Craxì A, Di Marco V, Volpes R et al. Treatment with recombinant Ó2b-interferon of chronic HDV hepatitis in children. Prog Clin Bio lRes 1991; 364: 399-404.
17. Smedile A, Rizzetto M, Denniston K et al. Delta hepatitis: the clinical significance of hepatitis delta virus RNA in serum as detected by a hybridation based assay. Hepatology 1986; 6: 1297-1302.
18. Knodell RG, Ishak KG, Black WC et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981; 1: 431-435.
19. Verme G, Brunetto MR, Oliveri F et al. Role of hepatitis delta virus infection in hepatocellular carcinoma. Dig Dis Sci 1991; 36: 1134-1136.
20. Craxi A, Di Marco V, Lo Iacono O et al. The natural history of chronic HDV infection. Prog Clin Biol Res 1993; 382: 301-310.
21. Raimondo G, Craxì A, Longo G et al. Delta infection in hepatocellular carcinoma positive for hepatitis B surface antigen. Ann Int Med 1984; 101: 343-344.
22. Bortolotti F, Cadrobbi P, Crivellaro C et al. Long-term outcome of chronic type B hepatitis in patients who acquire hepatitis B virus infection in childhood. Gastroenterology 1990; 99: 805-810.
23. Ilan Y, Klein A, Taylor J, Tur-Kaspa R. Resistance of hepatitis delta virus replication to interferon-α treatment in transfected human cells. J Infect Dis 1992; 166: 1164-1166.
24. McNair ANB, Monjardino J, Cheng D, Thomas HC. Hepatitis delta virus and the interferon system. Prog Clin Biol Res 1993; 382: 161-164.
25. Arrigoni A, Ponzetto A, Actis G, Bonino F. Levamisole and chronic delta hepatitis. Ann Intern Med 1983; 98: 1024.
26. Garripoli A, Di Marco V, Cozzolongo R et al. Ribavirin treatment for chronic hepatitis D: a pilot study. Liver 1994; 14: 154-157.
27. Buti M, Esteban R, Jardi R, Rodriguez F, Guardia J. Ribavirin therapy in chronic delta hepatitis. J Hepatol 1993; 19: 318.
28. Kay MH, Wyllie R, Deimler C, Caulfield M, Steffen R, Baetz-Greenwalt B. Alpha interferon therapy in children with chronic active hepatitis B and delta virus infection. J Pediatr 1993; 123: 1001-1004.
29. Chu C-M, Liaw Y-F. Intrahepatic expression of hepatitis B core and surface antigens in chronic hepatitis delta-virus infection. J Hepatol 1992; 16: 153-158.
30. Rosina F, Garripoli A, Fabiano A et al. Immunoblotting for the hepatitis delta antigen: Diagnostic role. Prog Clin Biol Res 1991; 364: 173-177.