Interaction of styrene and ethylmethylketone in the induction of cytochrome P450 enzymes in rat lung, kidney and liver after separate and combined inhalation exposures

Central European Journal of Public Health

Volumn 4, Issue 2, 1996, Pages 115-118

  Nedelcheva, V ^a  

^a NATIONAL INSTITUTE OF PUBLIC HEALTH   (Czech Republic)

Author keywords

Combined exposure; Ethylmethylketone; Immunodetection; P450 forms; Styrene

Indexed keywords

ALKANONE; CYTOCHROME P450; METHYLETHYL KETONE; STYRENE; STYRENE DERIVATIVE;

ANIMAL; ARTICLE; BIOSYNTHESIS; DRUG EFFECT; ELECTROPHORESIS; ENVIRONMENTAL EXPOSURE; ENZYME INDUCTION; ENZYMOLOGY; KIDNEY; LIVER; LUNG; MALE; RAT; WESTERN BLOTTING; WISTAR RAT;

ANIMALS; BLOTTING, WESTERN; BUTANONES; CYTOCHROME P-450 ENZYME SYSTEM; ELECTROPHORESIS; ENVIRONMENTAL EXPOSURE; ENZYME INDUCTION; KIDNEY; LIVER; LUNG; MALE; RATS; RATS, WISTAR; STYRENE; STYRENES;

EID: 0030133067     PISSN: 12107778     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Lehman, E., Gmehling, J., Weidlich, U.: Survey on organic solvents of various products and method for estimating workplace exposures Safety and Health aspects of organic solvents. A. R Liss, 1986, 31-34.
2. Leibman, K. C., Ortiz, E.: Oxidation of styrene in liver microsomes, Biochem Pharmacol. 18, 1969, 552-554.
3. de Meester, C., Poncelet, F., Roberfroid, M., Rondelet, J., Mercier, M.: Mutagenicity of styrene and styrene oxide. Mutat Res 56, 1977, 147-152.
4. Meretoja, T., Vainio, H., Jarventaus, H.: Clastogenic effects of styrene exposure on bone marrow cells of rat. Toxicol. Let. 1, 1978, 315-318.
5. Conti, B., Maltoni, C., Perino, G., Ciliberti, A.: Long term carcinogenicity bioassays on styrene administered by inhalation, ingestion and injection and styrene oxide administered by ingestion in Sprague-Dawley rats and Swiss mice. Ann. N. Y. Acad. Sci 534, 1988, 203-234.
6. Foureman, G. L., Harris, G., Guengerich, F. P., Bend, J.: Stereoselectivity of styrene oxidation in microsomes and in purified cytochrome P450 Enzymes form rat liver. J. Pharmacol. exp Ther 248, 1989, 492-496.
7. Nakajima, T., Elovaara, E., Gonzales, F., Gelboin, F., Raunio, H., Pelkonen, O., Vainio, H., Aoyama, T.: Styrene metabolism by cDNA-expressed human hepatic and pulmonary cytochromes P450 Chem. Res. Toxicol. 7, 1994, 891-896.
8. Gut, I., Terelius, Y., Frantík, E., Linhart, I., Souček, P., Filipcová, B., Klučková, H.: Exposure to various benzene derivatives differently induces cytochromes P450 2B1 and P450 2E1 in rat liver. Arch Toxicol. 67, 1993, 237-243.
9. Frantík, E., Kratochvíle, K.: Inhalation exposure apparatus with total evaporation of micropump delivered liquids In: Adverse effects of environmental chemicals and psychotropic drugs M. Horvath, E. Frantík [Eds], Elsevier, Amsterdam, 1976, Vol. 2, 320-324.
10. Lowry, O. H., Rosebrough, N. J., Farr, A. L., Randall, R. J.: Protein measurement with the Folin C phenol reagent J. biol. Chem. 193, 1951, 265-275.
11. Omura, T., Sato, R.: The carbon-monoxide-binding pigment of liver microsomes. II. Solubilization, purification, properties J. biol. Chem. 239, 1964, 2379-2385.
12. 4. Nature 227, 1970, 680-685.
13. Towbin, H., Staehelin, T., Gordon, J.: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc nat. Acad. Sci USA 76, 1979, 4350.
14. Johansson, I., Ekström, G., Scholte, B., Puzycki, D., Jörnvall, H., Ingelman-Sundberg, M.: Ethanol-, fasting-, and acetone-inducible cytochrome P-450 in rat liver: Regulation and characteristics of enzymes belonging to the IIB and IIE gene subfamilies Biochemistry 27, 1988, 1925-1934.
15. Tindberg, N., Ingelman-Sundberg, M.: Cytochrome P-450 and oxygen toxicity. Oxygen-dependent induction of ethanol- inducible cytochrome P-450 in rat liver and lung. Biochemistry 28, 1989, 4449-4504.
16. Peter, R., Bocker, R., Beaune, P. H., Iwasaki, M., Guengerich, F. P., Yang, C. S.: Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P450IIE1. Chem. Res Toxicol. 3, 1990, 566-573.
17. Lubet, R. A., Mayer, R. T., Cameron, J. W., Nims, R. W., Burcke, M. D., Wolf, T., Guengerich, F. P.: Dealkylation of pentoxyresorufin: a rapid and sensetive assay for measuring induction of cytochromes P450 by phenobarbital and other xenobiotics in the rat. Arch Biochem. Biophys 283, 1985, 43-48.
18. Burcke, M. D., Thopmson, S., Elcombe, C. R., Halpert, J., Haaparanta, T., Mayer, R. T.: Ethoxy-, penthoxy- and benzyloxy-phenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P450 Biochem Pharmacol 34, 1985, 3337-3345.
19. Vainio, H., Zitting, A.: Interaction of styrene and acetone with drug biotransformation enzymes in rat liver. Scand. J. Work Environ. Hlth 4, 1978, 47-52.
20. Raunio, H., Liira, J., Elovaara, E., Riihimaki, V., Pelkonen, O.: Cytochrome P450 izoenzyme induction by methyl ethyl ketone and m-xylene in rat liver. Toxicol. appl. Pharmacol. 24, 1989, 234-239.
21. Pakki, M. G., Marniemi, J., Vainio, H.: Action of styrene and its metabolites styrene oxide and styrene glycol on activities of xenobiotic transformation enzymes in rat liver in vivo Toxicol. appl Pharmacol. 38, 1976, 59-64.
22. Sandell, J., Parkki, M. G., Marniemi, J., Aitio, A.: Effect of inhalation of cutaneous exposure to styrene on drug metabolizing enzymes in the rat. Res. Commun. Chem Pathol. Pharmacol. 19, 1978, 109.