Examiantion of mutagenicity, genotoxicity, and cogenotoxicity of nitro musks in the environment;Untersuchungen zur Mutagenität, Genotoxizität und Kogenotoxizität umweltrelevanter Nitromoschusverbindungen

Zentralblatt fur Hygiene und Umweltmedizin

Volumn 198, Issue 5, 1996, Pages 429-442

  Mersch Sundermann, Volker ^a,b   Reinhardt, Alexander ^a,b   Emig, Michael ^a,b  

^a Inst F Med Mikrobiol Und Hygiene

^b MEDICAL FACULTY MANNHEIM HEIDELBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGEN; MONOUNSATURATED FATTY ACID; MUSK; NITRO DERIVATIVE; OXIDOREDUCTASE;

ANIMAL; ARTICLE; CULTURE TECHNIQUE; DNA DAMAGE; DOSE RESPONSE; DRUG EFFECT; ENZYME INDUCTION; ENZYMOLOGY; HUMAN; LIVER; MALE; METABOLISM; MUTAGEN TESTING; RAT; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CARCINOGENS, ENVIRONMENTAL; CULTURE TECHNIQUES; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; FATTY ACIDS, MONOUNSATURATED; HUMANS; LIVER; MALE; MUTAGENICITY TESTS; NITRO COMPOUNDS; OXIDOREDUCTASES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030132926     PISSN: 09348859     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Emig, M., R. Reinhardt, and V. Mersch-Sundermann: A comparative study of five nitro musk compounds for genotoxicity in the SOS chromotest and Salmonella mutagenicity. Toxicol. Lett, (in press)
2. Hahn, J.: Untersuchungen zum Vorkommen von Xylol-Moschus in Fischen. Deut. Lebensm-Rundsch. 89 (1993) 175-177
3. Ippen, H.: Nitromoschus. 1. Mitteilung Bundesgesundhbl. 94 (1994) 255-260
4. Ippen, H.: Nitromoschus. 2. Mitteilung Bundesgesundhbl. 94 (1994) 291-294
5. Iwata, N., K. Minegishi, K. Suzuki, Y. Ohno, T. Kawanishi, and T. Takahashi: Musk xylene is a novel specific inducer of cytochrome P450 IA2 Biochem. Biophys. Res. Commun. 184(1992) 149-153
6. Iwata, N., K. Minegishi, K. Suzuki, Y. Ohno, T. Igarashi, T. Satoh, and T. Takahashi: An unusual profile of musk xylene-induced drug metabolizing enzymes in rat liver. Biochem. Pharmacol. 45 (1993) 1659-1665
7. Lehman-McKeeman, L. D., D. Caudill, J. A. Young, and T. A. Dierckman: Musk xylene induces and inhibits mouse hepatic cytochrome P-450 2B enzymes. Biochem. Biophys. Res. Commun. 206 (1995) 975-980
8. Liebl, B. and S. Ehrenstorfer: Nitro musks in human milk. Chemosphere 27 (1993) 2253-2255
9. Maron, D. M. and B. N. Ames: Revised methods for the Salmonella mutagenicity test. Mutât. Res. 113 (1983) 173-215
10. Mersch-Sundermann, V., S. Kevekordes, and S. Mocbayedi: Sources of variability of the Erscherichia coli PQ37 genotoxicity assay (SOS chromotest). Mutât. Res. 252 (1990) 51-60
11. Mersch-Sundermann, V., S. Kern, and F. Wintermann: Genotoxicity of nitrated polycyclic aromatic hydrocarbons and related structures on Escherichia coli PQ37 (SOS chromotest). Environ. Mol. Mutagen. 18 (1991) 41-50
12. Mersch-Sundermann, V. and H. Krämer: The influence of culture conditions on the susceptibility of Salmonella typhimurium in the Salmonella mutagenicity test. Zbl. Hyg. 193 (1993) 471-480
13. Mersch-Sundermann, V., F. Wintermann, S. Kern, and H. Hof: Influence of S9 mix composition on the SOS response in Escherichia coli PQ37 by polycyclic aromatic hydrocarbons. Mutât. Res. 291 (1993) 53-60
14. Mersch-Sundermann, V., S. Mochayedi, S. Kevekordes, S. Kern, and F. Wintermann: The genotoxicity of unsubstituted and nitrated polycyclic aromatic hydrocarbons. Anticancer Res. 13 (1993) 2037-2044
15. Mersch-Sundermann, V., U. Schneider, G. Klopmann, and H. S. Rosenkranz: SOS induction in Escherichia coli and Salmonella mutagenicity: a comparison using 330 compounds. Mutagenesis 9 (1994) 205-224
16. Mersch-Sundermann, V., M. Emig, R. Reinhardt, and S. Kevekordes: DNA damages, micronocleus formation and P450 enzyme induction by nitro musks. Anticancer Res. 15/5A (1995) 1653-1654
17. Nair, J., H. Ohshima, C. Malaveille, M. Friesen, I. K. O'Neill, A. Hautefeuille, and H. Bartsch: Identification, occurence and mutagenicity in Salmonella typhimurium of two synthetic nitroarenes, musk ambrette and musk xylene, in Indian chewing tobacco and betel quid. Food Chem. Toxicol. 24 ( 1986) 27-31
18. Opdyke, D. L.: Musk tibetene. Food Cosm. Toxicol. 13 (1975) 879
19. Quillardet, P. and M. Hofnung: The SOS chromotest, a colorimetric bacterial assay for genotoxins: procedures. Mutât. Res. 147 (1985) 65-78
20. Rimkus, G. und M. Wolf: Rückstände und Verunreinigungen in Fischen aus Aquakultur. Dt. Lebensm. Rdsch. 89 (1.993) 171-175
21. Rimkus, G., B. Rimkus, and M. Wolf: Nitro tnusks in human adipose tissue and breast milk. Chemosphere 28 (1994) 421-432
22. Walker, G. C.: Mutagenesis and inducible response to desoxyribonucleic acids damage in Escherichia colt Microbiol. Rev. 48 (1984) 60-93
23. Wild, D., M. T. King, and £. Gocke: Study of artificial flavouring substances for mutagenicity in the Salmonella/microsome, base and micronucleus test. Food. Chem. Toxicol. 21 (1983) 707-719
24. Yamagishi, T., T. Miyazaki, S. Horii, and S. Kaneko: Identification of musk ketone in freshwater fish collected from the Tama River, Tokyo. Bull. Environ. Contam. Toxicol. 26(1981)656-662
25. "Yamagishi, T., T. Miyazaki, S. Horii, and K. Akiyama: Synthetic musk residues in biota and water form Tama River and Tokyo Bay (Japan) Arch. F.nviron. Contam. Toxicol. 12(1983) 83-89