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Volumn 1, Issue 3, 1996, Pages 191-203

Studies on the mechanism of action of 1-β-D-arabinofuranosyl-5-azacytosine (fazarabine) in mammalian lymphoblasts

Author keywords

DNA incorporation; Fazarabine; Mechanism of action; P388 and Molt 4 lymphoblasts; Phosphorylation

Indexed keywords

ANTINEOPLASTIC ANTIMETABOLITE; AZACITIDINE; DEOXYCYTIDINE; DNA; DRUG DERIVATIVE; FAZARABINE;

EID: 0030132023     PISSN: 13594117     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (6)

References (21)
  • 1
    • 0017672366 scopus 로고
    • The synthesis and anti-tumor activity of arabinosyl-5-azacytosine
    • Beisler JA, Abbasi MM, Driscoll JS. The synthesis and anti-tumor activity of arabinosyl-5-azacytosine. Biochem Pharmacol 26: 2469-2472, 1977.
    • (1977) Biochem Pharmacol , vol.26 , pp. 2469-2472
    • Beisler, J.A.1    Abbasi, M.M.2    Driscoll, J.S.3
  • 2
    • 0017801980 scopus 로고
    • Isolation, characterization and properties of a labile hydrolysis product of the antitumor nucleoside, 5-azacytidine
    • Beisler JA. Isolation, characterization and properties of a labile hydrolysis product of the antitumor nucleoside, 5-azacytidine. J Med Chem 21: 204-208, 1978.
    • (1978) J Med Chem , vol.21 , pp. 204-208
    • Beisler, J.A.1
  • 3
    • 0022620512 scopus 로고
    • Arabinosyl-5-azacytosine I: Antitumor and cytotoxic properties
    • Dalal M, Plowman J, Breitman TR, et al. Arabinosyl-5-azacytosine I: Antitumor and cytotoxic properties. Cancer Res 46: 831-838, 1986.
    • (1986) Cancer Res , vol.46 , pp. 831-838
    • Dalal, M.1    Plowman, J.2    Breitman, T.R.3
  • 4
    • 0024308824 scopus 로고
    • Arabinosyl-5-azacytosine activity against human tumors in athymic mice
    • Wallace RE, Lindth D, Durr FE. Arabinosyl-5-azacytosine activity against human tumors in athymic mice. Cancer Chemother Pharmacol 25: 117-123, 1989.
    • (1989) Cancer Chemother Pharmacol , vol.25 , pp. 117-123
    • Wallace, R.E.1    Lindth, D.2    Durr, F.E.3
  • 5
    • 0026666822 scopus 로고
    • A comparison of lethal effect in culture of cytosine arabinoside and arabinofuranosyl-5-azacytosine acting on the blast cells of acute myeloblastic leukemia
    • Yang GS, McCulloch EA. A comparison of lethal effect in culture of cytosine arabinoside and arabinofuranosyl-5-azacytosine acting on the blast cells of acute myeloblastic leukemia. Hematol Pathol 6: 125-130, 1992.
    • (1992) Hematol Pathol , vol.6 , pp. 125-130
    • Yang, G.S.1    McCulloch, E.A.2
  • 6
    • 0024443913 scopus 로고
    • Phase I trial and pharmacokinetic evaluation of fazarabine in children
    • Heideman RL, Gillespie A, Ford H, et al. Phase I trial and pharmacokinetic evaluation of fazarabine in children. Cancer Res 49: 5213-5216, 1989.
    • (1989) Cancer Res , vol.49 , pp. 5213-5216
    • Heideman, R.L.1    Gillespie, A.2    Ford, H.3
  • 9
    • 0025872404 scopus 로고
    • Clinical pharmacology of 1-β-D-arabinofuranosyl-5-azacytosine (fazarabine) following 72-hour infusion
    • Ho DH, Brown N, Lin JR, et al. Clinical pharmacology of 1-β-D-arabinofuranosyl-5-azacytosine (fazarabine) following 72-hour infusion. Drug Metab Disp 19: 643-664, 1991.
    • (1991) Drug Metab Disp , vol.19 , pp. 643-664
    • Ho, D.H.1    Brown, N.2    Lin, J.R.3
  • 10
    • 0021967065 scopus 로고
    • Metabolism of 1-β-D-arabinofuranosyl-5-azacytosine and incorporation into DNA of human T-lymphoblast cells (Molt-4)
    • Townsend A, Leclerc JM, Dutchman G, Cooney DA, Cheng Y-C. Metabolism of 1-β-D-arabinofuranosyl-5-azacytosine and incorporation into DNA of human T-lymphoblast cells (Molt-4). Cancer Res 45: 3522-3528, 1985.
    • (1985) Cancer Res , vol.45 , pp. 3522-3528
    • Townsend, A.1    Leclerc, J.M.2    Dutchman, G.3    Cooney, D.A.4    Cheng, Y.-C.5
  • 11
    • 0022540476 scopus 로고
    • Arabinosyl-5-azacytosine III: Mechanism of native and acquired resistance
    • Ahluwalia GS, Cohen M, Kang G, et al. Arabinosyl-5-azacytosine III: Mechanism of native and acquired resistance. Cancer Res 46: 4479-4485, 1986.
    • (1986) Cancer Res , vol.46 , pp. 4479-4485
    • Ahluwalia, G.S.1    Cohen, M.2    Kang, G.3
  • 12
    • 0003154873 scopus 로고
    • The prediction of biochemical mechanism of action from the in vitro antitumor screen of the National Cancer Institute
    • Foye WO ed. Washington:ACS
    • Paull KD, Hamel E, Malspeis L. The prediction of biochemical mechanism of action from the in vitro antitumor screen of the National Cancer Institute. In: Foye WO ed. Cancer Chemotherapeutic Agents, Washington:ACS 9-45, 1995.
    • (1995) Cancer Chemotherapeutic Agents , pp. 9-45
    • Paull, K.D.1    Hamel, E.2    Malspeis, L.3
  • 13
    • 0025775062 scopus 로고
    • Feasibility of a high-flux anticancer drugs screen utilizing a diverse panel of human tumor cell lines in culture
    • Monks A, Scudiero D, Skehan P, et al. Feasibility of a high-flux anticancer drugs screen utilizing a diverse panel of human tumor cell lines in culture. J Natl Cancer Inst 83: 757-766, 1991.
    • (1991) J Natl Cancer Inst , vol.83 , pp. 757-766
    • Monks, A.1    Scudiero, D.2    Skehan, P.3
  • 14
    • 0021668041 scopus 로고
    • 1-β-D-Arabinosyl-5-azacytosine: Cytocidal activity and effects on the synthesis and methylation of DNA in human colon carcinoma cells
    • Glazer RI, Knode, MC. 1-β-D-Arabinosyl-5-azacytosine: cytocidal activity and effects on the synthesis and methylation of DNA in human colon carcinoma cells. Mol Pharmocol 26: 381-387, 1984.
    • (1984) Mol Pharmocol , vol.26 , pp. 381-387
    • Glazer, R.I.1    Knode, M.C.2
  • 15
    • 0037798684 scopus 로고
    • Nucleic Acids Components and Their Analogues. LXVI. Hydrolysis of 5-azacytidine and its Connection with Biological Activity
    • Pithová P, Piskala A, Pitha J, Šorm F. Nucleic Acids Components and Their Analogues. LXVI. Hydrolysis of 5-azacytidine and its Connection with Biological Activity. Coll Czech Chem Comm 30: 2801-2811, 1965.
    • (1965) Coll Czech Chem Comm , vol.30 , pp. 2801-2811
    • Pithová, P.1    Piskala, A.2    Pitha, J.3    Šorm, F.4
  • 16
    • 27944485444 scopus 로고
    • The crystal and molecular structure of α-D-ribofurano[1′,2′:4,5]-2-oxazolidone, a decomposition product of 5-azacytidine
    • Singh P, Hodgson DJ. The crystal and molecular structure of α-D-ribofurano[1′,2′:4,5]-2-oxazolidone, a decomposition product of 5-azacytidine. Acta Cryst B32: 2329-2333, 1976.
    • (1976) Acta Cryst , vol.B32 , pp. 2329-2333
    • Singh, P.1    Hodgson, D.J.2
  • 17
    • 0019856151 scopus 로고
    • High-performance liquid Chromatographie analysis of chemical stability of 5-aza-2′-deoxycytidine
    • Lin K-T, Momparler RL, Rivard GE. High-performance liquid Chromatographie analysis of chemical stability of 5-aza-2′-deoxycytidine. J Pharm Sci 70: 1228-1232, 1981.
    • (1981) J Pharm Sci , vol.70 , pp. 1228-1232
    • Lin, K.-T.1    Momparler, R.L.2    Rivard, G.E.3
  • 18
    • 0023035969 scopus 로고
    • Differences in DNA damage produced by 5-aza-2′-deoxycytidine or 5,6-dihydro-5-azacytidine into DNA of mammalian cells
    • Covey JM, D'Lncalei M, Tilchen EJ, Zaharko DS, Kohn, KW. Differences in DNA damage produced by 5-aza-2′-deoxycytidine or 5,6-dihydro-5-azacytidine into DNA of mammalian cells. Cancer Res 46: 5511-5517, 1986.
    • (1986) Cancer Res , vol.46 , pp. 5511-5517
    • Covey, J.M.1    D'Lncalei, M.2    Tilchen, E.J.3    Zaharko, D.S.4    Kohn, K.W.5
  • 19
    • 0026575027 scopus 로고
    • The decomposition of 1-(β-D-ribofuranosyl)-1,2-dihydropyrimidin-2-one (zebularine) in alkali: Mechanism and products
    • Barchi JJ Jr, Musser S, Marquez VE. The decomposition of 1-(β-D-ribofuranosyl)-1,2-dihydropyrimidin-2-one (zebularine) in alkali: mechanism and products. J Org Chem 57: 536-541, 1992.
    • (1992) J Org Chem , vol.57 , pp. 536-541
    • Barchi Jr., J.J.1    Musser, S.2    Marquez, V.E.3
  • 20
    • 0018711735 scopus 로고
    • Synthesis and anti-tumor activity of 5-azacytosine arabinose
    • Beisler JA, Abbasi MM, Driscoll JS. Synthesis and anti-tumor activity of 5-azacytosine arabinose. J Med Chem 10: 1230-1234, 1979.
    • (1979) J Med Chem , vol.10 , pp. 1230-1234
    • Beisler, J.A.1    Abbasi, M.M.2    Driscoll, J.S.3
  • 21
    • 0024354465 scopus 로고
    • Cellular metabolism of 1-β-D-arabinofuranosyl-5-azacytidine and incorporation into DNA and RNA of human lymphoid CEM/O and CEM/deoxycytidine kinase deficient cells
    • Avramis VI, Powell WC, Mecum RA. Cellular metabolism of 1-β-D-arabinofuranosyl-5-azacytidine and incorporation into DNA and RNA of human lymphoid CEM/O and CEM/deoxycytidine kinase deficient cells. Cancer Chemother Pharmacol 25: 19-24, 1989.
    • (1989) Cancer Chemother Pharmacol , vol.25 , pp. 19-24
    • Avramis, V.I.1    Powell, W.C.2    Mecum, R.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.