Optimization of poly(ethylene glycol) precipitation of hepatitis a virus used to prepare VAQTA, a highly purified inactivated vaccine

Biotechnology Progress

Volumn 12, Issue 3, 1996, Pages 406-412

  Hagen, Anna J ^a   Oliver, Cynthia N ^a,b   Sitrin, Robert D ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Medlmmune Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLOMERATION; BIOTECHNOLOGY; CHROMATOGRAPHY; ENZYMES; IONIC STRENGTH; MOLECULAR WEIGHT DISTRIBUTION; NUCLEIC ACIDS; OPTIMIZATION; PH; POLYETHYLENE GLYCOLS; PRECIPITATION (CHEMICAL); VACCINES;

ANION EXCHANGE CHROMATOGRAPHY; CRUDE LYSATE; HEPATITIS; HIGHLY PURIFIED FORMALIN INACTIVATED VACCINE; NUCLEASE; SEMIPERMEABLE MEMBRANES;

VIRUSES;

HEPATITIS A VACCINE; HEPATITIS VACCINE; INACTIVATED VACCINE; MACROGOL DERIVATIVE; SODIUM CHLORIDE; VIRUS DNA;

ARTICLE; CHEMISTRY; HEPATITIS A VIRUS; IMMUNOLOGY; ISOLATION AND PURIFICATION; OSMOLARITY; PH; PRECIPITATION; TEMPERATURE; TIME;

DNA, VIRAL; HEPATITIS A VACCINES; HEPATITIS A VIRUS, HUMAN; HYDROGEN-ION CONCENTRATION; OSMOLAR CONCENTRATION; POLYETHYLENE GLYCOLS; PRECIPITATION; SODIUM CHLORIDE; TEMPERATURE; TIME FACTORS; VACCINES, INACTIVATED; VIRAL HEPATITIS VACCINES;

EID: 0030131710     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp950081g     Document Type: Article

References (13)

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