Biodegradable microparticles as a delivery system for measles virus cytotoxic T cell epitopes

Molecular Immunology

Volumn 33, Issue 6, 1996, Pages 485-491

  Partidos, C D ^a   Vohra, P ^a   Anagnostopoulou, C ^a   Jones, D H ^b   Farrar, G H ^b   Steward, M W ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

CTL epitopes; Measles virus; PLG microparticles

Indexed keywords

EPITOPE; MEASLES VACCINE; POLYGLACTIN; SYNTHETIC PEPTIDE;

ANIMAL EXPERIMENT; ARTICLE; BIODEGRADATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DRUG DELIVERY SYSTEM; IMMUNIZATION; INTRAPERITONEAL DRUG ADMINISTRATION; MEASLES; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA; MEASLES VIRUS;

EID: 0030131086     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/0161-5890(96)00032-6     Document Type: Article

References (36)

1. Aguado M. T. and Lambert P. H. (1992) Controlled-release vaccines - Biodegradable polylactide-polyglycolide (PL/PG) microspheres as antigen vehicles. Immunobiology 184, 113-125.
2. Alonso M. J., Gupta R. K., Min C., Siber G. R. and Longer R. (1994) Biodegradable microspheres as controlled release tetanus toxoid delivery systems. Vaccine 12, 299-306.
3. k restricted cytotoxic T lymphocyte epitopes in the measles virus nucleoprotein. Virology 203, 172-177.
4. Deres K., Schild H., Weismuller K. H., Jung G. and Rammensee H. G. (1989) In vivo priming of virus specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine. Nature 342, 561-564.
5. Eldridge J.H., Staas J.K., Meulbroek J.A., McGhee J.R., Tice T.R. and Gilley R.M. (1991a) Biodegradable microspheres as a vaccine delivery system. Molec. Immun. 28, 287-294.
6. Eldridge J.H., Staas J.K., Meulbroek J.A., Tice T.R. and Gilley R.M. (1991b) Biodegradable and biocompatible poly(dl-lactide-co-glycolide) microspheres as an adjuvant for staphylococcal enterotoxin B toxoid which enhances the level of toxin-neutralizing antibodies. Infect. Immun. 59, 2978-2986.
7. + T cell help. J. Immun. 147, 4069-4073.
8. Fooks A. R., Schadeck E., Liebert U. G., Dowsett B., Rima B. K., Steward M. W., Stephenson J. R. and Wilkinson G. W. G. (1995) High-level expression of the measles virus nucleocapsid protein by using a replication-deficient adenovirus vector: Induction of an MHC-1 restricted CTL response and protection in a murine model. Virology 210, 456-485.
9. Good R. A. and Zak S. J. (1956) Disturbances in gamma globulin synthesis as experiments of nature. Pediatrics 18, 109-112.
10. Gopas J., Itzhaky D., Segev Y., Salzberg S., Trink B., Isakov N. and Rager-Zisman B. (1992) Persistent measles virus infection enhances major histocompatibility complex class I expression and immunogenicity of murine neuroblastoma cells. Cancer Immun. Immunother. 34, 313-320.
11. Hora M. S., Rana R. K., Nunberg J. H., Tice T. R., Gilley R. M. and Hudson M. E. (1990) Release of human serum albumin from poly(lactide-co-glycolide) microspheres. Pharm Res. 7, 1190-1195.
12. Jones D. H., McBride B. W., Jeffery H., O'Hagan D. T., Robinson A. and Farrar G. H. (1995) Protection of mice from Bordetella pertussis respiratory infection using microencapsulated pertussis fimbriae. Vaccine 13, 675-681.
13. Kast W. M., Roux L., Curren J., Blom H. J. J., Voordouw A. C., Meloen R. H., Kolakofsky D. and Melief C. J. M. (1991) Protection against lethal Sendai virus infection by in vivo priming of virus specific cytotoxic T lymphocytes with a free synthetic peptide. Proc. Natn. Acad. Sci. U.S.A. 88, 2283-2287.
14. + cytotoxic T cells. Vaccine 12, 73-80.
15. Maloy K. J., Donachie M. A., O'Hagan D. T. and Mowat A. (1994) Induction of mucosal and systemic immune responses by immunization with ovalbumin entrapped in poly(lactide-co-glycolide) microparticles. Immunology 81, 661-667.
16. Marx P. A., Compans R. W., Gettie X., Staas J. K., Gilley R. M., Mulligan M. J., Yamshchikov G. V., Chen D. and Eldridge J. H. ( 1993) Protection against vaginal SIV transmission with microencapsulated vaccine. Science 260, 1323-1327.
17. Men Y., Corradin G., Thomasin C., Merkle H. P. and Gander B. (1994) Immunopotentiation of a synthetic antigen by-incorporation into biodegradable microspheres. Proceed. Int. Symp. Control Rel. bioact. Mater. 21, 50-51.
18. Milich D. R. (1989) Synthetic T and B recognition sites:implications for vaccine development. Adv. Immun. 45, 195-264.
19. + cytotoxic T lymphocytes. J. exp. Med. 176, 1739-1744.
20. Miller R. A., Brady J. M. and Cutwright D. E. (1977) Degradation rates of resorbable implants (polylactides and polyglycolides): Rate modification with changes in PLA/PLGA copolymer ratios. J. biomed. Mater. Res. 11, 711-715.
21. Nair S., Zhou F., Reddy R., Huang L. and Rouse B. T. (1992) Soluble protein delivered to dendritic cells via pH-sensitive liposomes induce primary cytotoxic T lymphocyte responses in vitro. J. exp. Med. 175, 609-612.
22. Nair S., Buiting A. M. J., Rouse R. J. D., van Rooijen N., Huang L. and Rouse B. T. (1995) Role of macrophages and dendritic cells in primary cytotoxic T lymphocyte responses. Int. Immun. 7, 679-688.
23. Obeid E. O., Partidos C. D., Howard C. R. and Steward M. W. (1995) Protection against morbillivirus induced encephalitis by immunization with a rationally designed synthetic peptide vaccine containing B and T cell epitopes from the fusion protein of measles virus. J. Virol. 69, 1420-1428.
24. Partidos C. D. and Steward M. W. (1990) Prediction and identification of a T cell epitope in the fusion protein of measles virus immunodominant in mice and humans. J. gen. Virol. 71, 2099-2105.
25. Partidos C. D., Stanley C. M. and Steward M. W. (1991) Immune responses in mice following immunization with chimeric synthetic peptides representing B and T cell epitopes of measles virus. J. gen. Virol. 72, 1293-1299.
26. Partidos C. D., Shaw D. M., Gander G., Merkle H. P., Howard C. R. and Steward M. W. (1994) Induction of antibody responses to a synthetic peptide entrapped in biodegradable microparticles. Vaccine Res. 3, 203-209.
27. Partidos C. D., Vohra P. and Steward M. W. (1996) Induction of measles virus specific cytotoxic T cell responses after intranasal immunization with synthetic peptides. Immunology 87, 179-185.
28. Rager-Zisman B., Egan J. E., Kress Y. and Bloom B. R. (1984) Isolation of cold-sensitive mutants of measles virus from persistently infected murine neuroblastoma cells. J. Virol. 51, 845-855.
29. Redding T. W., Schally A. V., Tice T. R. and Meyers W. E. (1984) Long acting delivery systems for peptides: Inhibition of rat prostate tumors by controlled release of D-Trp 6-LH-RH from injectable microparticles. Proc. natn. Acad. Sci. U.S.A. 81, 5845-5847.
30. Reddy R., Zhou F., Nair S., Huang L. and Rouse B. T. (1992) In vivo cytotoxic T lymphocyte induction with soluble proteins administered in liposomes. J. Immun. 148, 1585-1589.
31. Rock K. L., Rothstein L., Fleischacker C. and Gamble S. (1992) Inhibition of class I and class II MHC restricted antigen presentation by cytotoxic T lymphocytes specific for an exogenous antigen. J. Immun. 148, 3028-3033.
32. Rouse B. T., Norley S. and Martin S. (1988) Antiviral cytotoxic T lymphocyte induction and vaccination. Rev. infect. Dis. 10, 16-31.
33. Saha K. and Wong P. K. Y. (1992) Protective role of cytotoxic Lymphocytes against Leukemia virus-induced neurologic disease and immunodeficiency is enhanced by the presence of helper T cells. Virology 188, 921-925.
34. Tabata Y. and Ikada Y. (1990) Phagocytosis of polymer microspheres by macrophages. Adv. Polym. Sci. 94, 107-141.
35. Townsend A. and Bodmer H. (1989) Antigen recognition of class I restricted T lymphocytes. A. Rev. Immun. 7, 601-624.
36. Widmann C., Romero P., Maryanski J. L., Corradin G. and Valmori D. (1992) T helper epitopes enhance the cytotoxic response of mice immunized with MHC class I restricted malaria peptides. J. immunol. Meth. 155, 95-99.