A novel and efficient route for the isolation of antibodies that recognise T cell receptor Vαs

Molecular Immunology

Volumn 33, Issue 6, 1996, Pages 493-502

  Popov, Sergei ^a   Hubbard, J Gregory ^a   Ward, E Sally ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Antibodies; Phage display; Single chain Fv; T cell receptor

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ANTIBODY PRODUCTION; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYBRIDOMA; IMMUNOTHERAPY; PRIORITY JOURNAL; SERODIAGNOSIS;

EID: 0030130966     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/0161-5890(96)00020-X     Document Type: Article

References (73)

1. Acha-Orbea H., Mitchell D. J., Timmerman L., Wraith D. C., Tausch G. S., Waldor M. K., Zamvil S. S., McDevitt H. O. and Steinman L. (1988) Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 54, 263.
2. Barbas C. F., Bain J. D., Hoekstra D. M. and Lerner R. A. (1992) Semisynthetic combinatorial antibody libraries: a chemical solution to the diversity problem. Proc. natn. Acad. Sci. U.S.A. 89, 4457.
3. Benhar I. and Pastan I. (1994) Cloning, expression and characterization of the Fv fragments of the anti-carbohydrade mAbs B1 and B5 as single chain immunotoxins. Protein Engng. 11, 1509.
4. Bird R. E., Hardman K. D., Jacobson J. W., Johnson S., Kaufman B. M., Lee S.-M., Lee T., Pope S. H., Riordan G. S. and Whitlow M. (1988) Single-chain antigen-binding proteins. Science 242, 423.
5. Breitling F., Dübel S., Seehaus T., Klewinghaus I. and Little M. (1991) A surface expression vector for antibody screening. Gene 104, 157.
6. Burton D. R., Barbas C. F., Persson M. A. A., Koenig S., Chanock R. M. and Lerner R. A. (1991) A large array of human monoclonal antibodies to type I human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals. Proc. natn. Acad. Sci. U.S.A. 88, 10134.
7. Callan M. F. C., Reyburn H. T., Bowness P., Ottenhoff T. H., Engel I., Klausner R. D., Bell J. I. and McMichael A. (1993) A method for producing monoclonal antibodies to human T cell-receptor β-chain variable regions. Proc. natn. Acad. Sci. U.S.A. 90, 10454.
8. Choi Y., Kotzin B., Lafferty J., White J., Pigeon M., Kubo R., Kappler J. and Marrack P. (1991) A method for the production of antibodies to human T cell receptor β-chain variable regions. Proc. natn. Acad. Sci. U.S.A. 88, 8357.
9. Ciubotaru M. and Ward E. S. (1994) Expression of soluble T cell receptor fragment derived from T cell clone associated with murine collagen induced arthritis. Immun. Lett. 43, 139.
10. Clackson T., Hoogenboom H. R., Griffiths A. D. and Winter G. (1990) Making antibody fragments using phage display libraries. Nature 352, 624.
11. Deng S. J., Mackenzie C. R., Sadowska J., Michniewicz J., Young N. M., Bundel D. R. and Narang S. A. (1994) Selection of antibody single-chain variable fragments with improved carbohydrate binding by phage display. J. biol. Chem. 269, 9533.
12. DerSimonian H., Band H. and Brenner M. B. (1991) Increased frequency of T cell receptor Vα12.1 expression on CD8+ T cells: evidence that Vα participates in shaping the peripheral T cell repertoire. J. exp. Med. 174, 639.
13. Devaux B., Bjorkman P. J., Stevenson C., Greif W., Elliott J.-F., Sagerström C., Clayberger C., Krensky A. M. and Davis M. M. (1991) Generation of monoclonal antibodies against soluble human T cell receptor polypeptides. Eur. J. Immun. 21, 2111.
14. Diu A., Romagne F., Genevee C., Bruneau J.-M., David A., Praz F. and Hercend T. (1993) Fine specificity of monoclonal antibodies directed at human T cell receptor variable regions: comparison with oligonucleotide-driven amplification for evaluation of Vβ expression. Eur. J. Immun. 23, 1422.
15. Dower W. J., Miller J. F. and Ragsdale C. W. (1988) High efficiency transformation of E. coli by high voltage electroporation. Nucl. Acids Res. 16, 6127.
16. Engel I., Ottenhoff T. H. M. and Klausner R. D. (1992) High-efficiency expression and solubilization of functional T cell antigen receptor heterodimers. Science 256, 1318.
17. Essig N. Z., Wood J. F., Howard A. J., Raag R. and Whitlow M. (1993) Crystallization of single-chain Fv proteins. J. molec. Biol. 234, 897.
18. Evan G. I., Lewis G. K., Ramsay G. and Bishop J. M. (1985) Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Molec. cell. Biol. 5, 3610.
19. Fields B. A., Ysern X., Poljak R., Shao X., Ward E. S. and Mariuzza R. A. (1994) Crystallization and preliminary X-ray diffraction study of a bacterially produced T cell antigen receptor Vα domain. J. molec. Biol. 239, 339.
20. Gascoigne N. R. J., Goodnow C. C., Dudzik K. I., Oi V. T. and Davis M. M. (1987) Secretion of a chimeric T cell receptor-immunoglobulin protein. Proc. natn. Acad. Sci. U.S.A. 84, 2936.
21. Gascoigne N. R. J. and Ames K. T. (1991) Direct binding of secreted T cell receptor β chain to superantigen associated with class II major histocompatibility complex protein. Proc. natn. Acad. Sci. U.S.A. 88, 613.
22. George A. J. T., Titus J. A., Jost C. R., Kurucz I., Perez P., Andrew S. M., Nicholls P. J., Huston J. S. and Segal D. M. (1994) Redirection of T cell mediated cytotoxicity by a recombinant single-chain Fv molecule. J. Immun. 152, 1802
23. Gibson, T. J. (1984) PhD. Thesis. University of Cambridge. U.K.
24. Gold D. P., Offner H., Sun D., Wiley S., Vandenbark A. A. and Wilson D. B. (1991) Analysis of T cell receptor β chains in Lewis rats with experimental allergic encephalomyelitis: conserved complementarity determining region 3. J. exp. Med. 174, 1467.
25. Gram H., Marconi L.-A., Barbas C. F., Collet T. A., Lerner R. A. and Kang A. S. (1992) In vitro selection and affinity maturation of antibodies from a naive combinatorial immunoglobulin library. Proc. natn. Acad. Sci. U.S.A. 89, 3576.
26. Gregoire C., Rebai N., Schweisguth F., Necker A., Mazza G., Auphan N., Millward A., Schmitt-Verhulst A.-M. and Malissen B. (1991) Engineered secreted T cell receptor αβ heterodimers. Proc. natn. Acad. Sci. U.S.A. 88, 8077.
27. Griffiths A. D., Malmquist M., Marks J. D., Bye J. M., Embleton M. J., McCafferty J., Baier M., Holliger K. P., Gorick B. D., Hughes-Jones N. C., Hoogenboom H. R. and Winter G. (1993) Human anti-self antibodies with high specificities from phage display libraries. EMBO J. 12, 725.
28. Griffiths A. D., Williams S. C., Hartley O., Tomlinson I. M., Waterhouse P., Crosby W. L., Kontermann R. E., Jones P. T., Low N. M., Allison T. J., Prospero T. D., Hoogenboom H. R., Nissim A., Cox J. P. L., Harrison J. L., Zaccolo M., Gheradi E. and Winter G. (1994) Isolation of high affinity human antibodies directly from large synthetic repertoires. EMBO J. 13, 3245
29. Harlow, E. and Lane, D. (1988) In Antibodies - A Laboratory Manual. Cold Spring Harbor Laboratories, Cold Spring Harbor, New York.
30. Hawkins R. E., Russell S. J. and Winter G. (1992) Selection of phage antibodies by binding affinity. J. molec. Biol. 226, 889.
31. Holliger P., Prospero T. and Winter G. (1993) "Diabodies": small bivalent and bispecific antibody fragments. Proc. natn. Acad. Sci. U.S.A. 90, 6444.
32. Hoogenboom H. R., Griffiths A. D., Johnson K. S., Chiswell D. J., Hudson P. and Winter G. (1991) Multi-subunit proteins on the surface of filamentous phage: methodologies for displaying antibody (Fab) heavy and light chains. Nucl. Acids Res. 19, 4133.
33. Hoogenboom H. R., Marks J. D., Griffiths A. D. and Winter G. (1992) Building antibodies from their genes. Immun. Rev. 130, 41.
34. Hoogenboom H. R. and Winter G. (1992) By-passing immunisation: human antibodies from synthetic repertoires of germline VH gene segments rearranged in vitro. Molec. Biol. 227, 381.
35. Horton R. M., Hunt H. D., Ho S. N., Pullen J. K. and Pease L. R. (1989) Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene 77, 61.
36. Howell M. D., Diveley J. P., Lundeen K. A., Esty A., Winters S. T., Carlo D. J. and Brostoff S. W. (1991) Limited T cell receptor β-chain heterogeneity among interleukin 2 receptor-positive synovial T cells suggests a role for superantigen in rheumatoid arthritis. Proc. natn. Acad. Sci. U.S.A. 88, 10921.
37. Huse W. D., Sastry L., Iverson S. A., Kang A. S., Alting-Mees M., Burton D. R., Benkovic S. J. and Lerner R. A. (1989) Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. Science 246, 1275.
38. Huston J. S., Levinson D., Mudgett-Hunter M., Tai M.-S., Novotny J., Margolies M. N., Ridge R. J., Bruccoleri R. E., Haber E., Crea R. and Opperman H. (1988) Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single chain Fv analogue produced in Escherichia coli. Proc. natn. Acad. Sci. U.S.A. 85, 5879.
39. Jameson S. C., Kaye J., Gascoigne N. R. J. (1989) A T cell receptor Vα region selectively expressed in CD4+ cells. J. Immun. 145, 1324
40. Rabat E. A., Wu T. T., Perry H. M., Gottesman K. S. and Foeller C. (1991) Sequences of Proteins of Immunological Interest. U.S. Department of Health and Human Services, National Institutes of Health, Bethesda, MD.
41. Kang A.S., Barbas C.F., Janda K.D., Benkovic S.J. and Lerner R.A. (1991a) Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces. Proc. natn. Acad. Sci. U.S.A. 88, 4363.
42. Kang A.S., Jones T.M. and Burton D.R. (1991b) Antibody redesign by chain shuffling from random combinatorial immunoglobulin libraries. Proc. natn. Acad. Sci. U.S.A. 88, 11120.
43. Kipriyanov S. M., Dubel S., Breitling F., Kontermann R. E. and Little M. (1994) Recombinant single-chain Fv fragments carrying C-terminal cysteine residues: production of bivalent and biotinylated miniantibodies. Molec. Immun. 31, 1047.
44. Köhler G. and Milstein C. (1975) Continuous culture of fused cells secreting antibody of predefined specificity. Nature 256, 495.
45. Larrick J. W., Danielsson L., Brenner C. A., Abrahamson M., Fry K. E., Borrebaeck C. A. K. (1989) Rapid cloning of rearranged immunoglobulin genes from human hybridoma cells using mixed primers and the polymerase chain reaction. Biochem. biophys. Res. Commun. 160, 1250.
46. Lin A. Y., Devaux B., Green A., Sagerström C., Elliott J. F. and Davis M. M. (1990) Expression of T cell antigen receptor in a lipid-linked form. Science 249, 677.
47. Marks J. D., Hoogenboom H. R., Bonnert T. P., McCafferty J., Griffiths A. D. and Winter G. (1991) By-passing immunization: human antibodies from V-gene libraries displayed on phage. J. molec. Biol. 222, 581.
48. Marks J.D., Griffiths A.D., Malmqvist M., Clackson T.P., Bye J.M. and Winter G. (1992a) By-passing immunization: building high affinity human antibodies by chain shuffling. BioTechnology 10, 779.
49. Marks J.D., Hoogenboom H.R., Griffiths A.D. and Winter G. (1992b) Molecular evolution of proteins on filamentous phage. J. biol. Chem. 267, 16007-16010.
50. Mariuzza R. A. and Winter G. (1989) Secretion of a homodimeric VαCα T cell receptor-immunoglobulin chimeric protein. J. biol. Chem. 264, 7310.
51. McCafferty J., Griffiths A. D., Winter G. and Chiswell D. J. (1990) Phage antibodies: filamentous phage displaying antibody variable domains. Nature 348, 552.
52. Miller, J. H. (1972) In Experiments in Molecular Genetics. Cold Spring Harbor Laboratories, Cold Spring Harbor, New York.
53. Myers L. K., Rosloniec E. F., Seyer J. M., Stuart J. M. and Kang A. H. (1993) A synthetic peptide analogue determinant of type II collagen prevents the onset of collagen-induced arthritis. J. Immun. 150, 4652.
54. Nissim A., Hoogenboom H. R., Tomlinson I. A., Flynn G., Midgley C., Lane D. and Winter G. (1994) Antibody fragments from a "single pot" phage display library as immunochemical reagents. EMBO J. 13, 692.
55. Novotny J., Ganju R. K., Smiley S. T., Hussey R. E., Luther M. A., Recny M. A., Siciliano R. F. and Reinherz E. L. (1991) A soluble, single-chain T cell receptor fragment endowed with antigen-combining properties. Proc. natn. Acad. Sci. U.S.A. 88, 8646.
56. Oksenberg J. R., Stuart S., Begovich A. B., Bell R. B., Erlich H. A., Steinman L. and Bernard C. C. A. (1990) Limited heterogeneity of rearranged T cell receptor Vα transcripts in brains of multiple sclerosis patients. Nature 345, 344.
57. Oksenberg J. R., Panzara M. A., Begovich A. B., Mitchell D., Erlich H. A., Murray R. S., Shimonkevitz R., Sherrit J., Rothbard J., Bernard C. C. A. and Steinman L. (1993) Selection of T cell receptor Vβ-Dβ-Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis. Nature 362, 68.
58. Orlandi R., Güssow D. H., Jones P. T. and Winter G. (1989) Cloning immunoglobulin variable domains for expression by the polymerase chain reaction. Proc. natn. Acad. Sci. U.S.A. 86, 3833.
59. Osman G. E., Toda M., Kanagawa O. and Hood L. E. (1993) Characterization of the T cell receptor repertoire causing collagen arthritis in mice. J. exp. Med. 177, 387.
60. Paliard X., West S. G., Lafferty J. A., Clements J. R., Kappler J. W., Marrack P. and Kotzin B. L. (1991) Evidence for the effects of superantigen in rheumatoid arthritis. Science 253, 325.
61. Soo Hoo W. F., Lacy M. J., Denzin L. K., Voss E. W., Hardman K. D. and Kranz D. M. (1992) Characterization of a single-chain T cell receptor expressed in Escherichia coli. Proc. natn. Acad. Sci. U.S.A. 89, 4759.
62. Staerz U. D., Rammensee H.-G., Benedetto J. D. and Bevan M. J. (1985) Characterization of a mirine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor. J. Immun. 134, 3994.
63. Traunecker A., Dolder B. and Karjalainen K. (1986) A novel approach for preparing anti-T cell receptor constant region antibodies. Eur. J. Immun. 16, 851.
64. Waldmann T. A. (1991) Monoclonal antibodies in diagnosis and therapy. Science 252, 1657.
65. Ward E. S., Güssow D. H., Griffiths A. D., Jones P. T. and Winter G. (1989) Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli. Nature 341, 544.
66. Ward E. S. (1991) Expression and secretion of T cell receptor Vα and Vβ domains using Escherichia coli cells. Scand. J. Immun. 34, 215.
67. Ward E.S. (1992a) Antibody engineering: the use of Escherichia coli as an expression host. FASEB J. 6, 2422.
68. Ward E.S. (1992b) Secretion of T cell receptor fragments from recombinant Escherichia coli cells. J. molec. Biol. 224, 885.
69. Ward E. S. (1995) VH shuffling can be used to convert an Fv fragment of anti-hen egg lysozyme specificity to one that recognises a T cell receptor Vα. Molec. Immun. 32, 147-156.
70. Whitlow M., Filpula D., Rollence M. L., Feng S.-L. and Wood J. F. (1994) Multivalent Fvs: characterization of single-chain Fv oligomers and preparation of a bispecific Fv. Protein Engng. 7, 1017.
71. Wraith D. C., Smilek D. E., Mitchell D. J., Steinman L. and McDevitt H. O. (1989) Antigen recognition in autoimmune encephalomyelitis and the potential for peptide mediated therapy. Cell 59, 247.
72. Wucherpfennig K. W., Ota K., Endo N., Seidman J. G., Rosenzweig A., Weiner H. L. and Hafler D. A. (1990) Shared human T cell receptor Vβ usage to immunodominant regions of myelin basic protein. Science 248, 1016.
73. Zumla A., McCormack A., George A., Batchelor R. and Lechler R. (1992) Use of a murine T cell hybridoma expressing human T cell receptor α and β-gene products as a tool for the production of human T cell receptor-specific antibodies. Hum. Immun. 35, 141.