Strategies for reducing isotopic dilution in the synthesis of 18F-labeled polyfluorinated ethyl groups

Applied Radiation and Isotopes

Volumn 47, Issue 4, 1996, Pages 401-407

  Johnström, Peter S ^a   Stone Elander, Sharon ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

DISTILLATION; ESTERS; FLUORINE; ISOTOPES; SYNTHESIS (CHEMICAL);

ETHYL BROMODIFLUOROACETATE; ETHYL TRIFLUOROACETATE; FLUORODEBROMINATION REACTION; FUNCTIONALIZED MERRIFIELD RESIN; ISOTOPIC DILUTION; OXAZOLINE; POLYFLUORINATED ETHYL GROUPS; RADIOACTIVE LABELING; TRIFLUOROETHYL TRIFLATE;

FLUOROCARBONS;

FLUORINE 18; TRIFLUOROTHIOACETIC ACID ETHYL ESTER; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ISOTOPE LABELING; PRIORITY JOURNAL;

EID: 0030130817     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/0969-8043(95)00321-5     Document Type: Article

References (22)

1. 18F in the 1-position. J. Chem. Soc., Chem. Commun. 1064.
2. Das M. K. and Mukherjee J. (1993) Radiosynthesis of [F-18]fluoxetine as a potential radiotracer for serotonin reuptake sites. Appl. Radiat. Isot. 44, 835.
3. 18F-labeled HFA-134a. Appl. Radiat. Isot. 46, 241.
4. Gordon A. J. and Ford R. A. (1972) The Chemist's Companion: A Handbook of Practical Data, Techniques and References. Wiley, New York.
5. Green T. W. (1981) Protective Groups in Organic Synthesis. Wiley, New York.
6. 18F]-(S)-fluoxetine: a selective serotonin uptake inhibitor. J. Label. Compds. Radiopharm. 33, 703.
7. Hwang D. -R., MoerLein S. M., Lang L. and Welch M. J. (1987) Application of microwave technology to the synthesis of short-lived radiopharmaceuticals. J. Chem. Soc., Chem. Commun. 1799.
8. 18F]labeling of tresylate. J. Label. Compds. Radiopharm. 32, 104.
9. Johnström P. and Stone-Elander S. (1994) Synthesis of fluorine-18 labeled 2,2,2-trifluoroethyl triflate. J. Label. Compds. Radiopharm. 35, 146.
10. 18F-labelled alkylating agent 2,2,2-trifluoroethyl triflate: synthesis and specific activity. J. Label. Compds. Radiopharm. 36, 537.
11. Lemaire C., Cantineau R., Guillaume M., Plenevaux A. and Christiaens L. (1991) Fluorine-18 altanserin: a radioligand for the study of serotonin receptors with PET: radiolabeling and in vivo biologic behavior in rats. J. Nucl. Med. 32, 2266.
12. 18F]fluoromisonidazole. Appl. Radiat. Isot. 44, 1129.
13. Meyers A. I., Temple D. L., Nolen R. L. and Mihelich E. D. (1974) Oxazolines. IX. Synthesis of homologated acetic acids and esters. J. Org. Chem. 39, 2778.
14. Mulholland G. K. and Jewett D. M. (1995) Solid phase reagents in radiosynthesis. Chemists' View of Imaging Centers (A. M. Emran, Ed.), Plenum Press. New York.
15. 11C]cyanide ion on quaternary ammonium resins. J. Label. Compas. Radiopharm. 26, 378.
16. 18F]fluoride. Acta Radiol. Suppl. 376, 59.
17. Roush D. M. and Patel M. M. (1985) A mild procedure for the preparation of 2-oxazolines. Synth. Commun. 15, 675.
18. Satter M. R., Martin C. C., Oakes T. R., Christian B. F. and Nickles R. J. (1994) Synthesis of the fluorine-18 labeled inhalation anesthetics. Appl. Radiat. Isot. 45, 1093.
19. 11C]alkyl halides. J. Label. Compds. Radiopharm. 34, 949.
20. 11C]cyanide. J. Label. Compds. Radiopharm. 31, 207.
21. 18F]fluoro-D-glucose by direct nucleophilic exchange on a quaternary 4-aminopyridinium resin. Nucl. Med. Biol. 17, 273.
22. 18F]fluoroalkyiations of aporphine and tetralin derivatives. J. Org. Chem. 58, 1643.