No evidence for a protective effect of ascorbic acid on free radical generation and liver injury after hemorrhagic shock in rats

Shock

Volumn 5, Issue 4, 1996, Pages 280-283

  Minor, Thomas ^a   Niessen, Frank ^a   Klauke, Hiltrud ^a   Isselhard, Wolf ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; AMMONIA; ASCORBIC ACID; FREE RADICAL; LACTATE DEHYDROGENASE; MALONALDEHYDE; PEROXIDASE;

ANIMAL; ARTICLE; BLOOD; DRUG EFFECT; HEMODYNAMICS; HEMORRHAGIC SHOCK; LIVER; MALE; METABOLISM; PATHOPHYSIOLOGY; RAT; RESUSCITATION; WISTAR RAT;

ALANINE TRANSAMINASE; AMMONIA; ANIMALS; ASCORBIC ACID; FREE RADICALS; HEMODYNAMIC PROCESSES; L-LACTATE DEHYDROGENASE; LIVER; MALE; MALONDIALDEHYDE; PEROXIDASE; RATS; RATS, WISTAR; RESUSCITATION; SHOCK, HEMORRHAGIC;

EID: 0030124086     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-199604000-00008     Document Type: Article

References (25)

1. Marotto ME, Thurman RG, Lemasters JJ: Early midzonal cell death during low-flow hypoxia in the isolated perfused rat liver: Protection by allopurinol. Hepatology 8:585-890, 1988.
2. Minor Th, Isselhard W, Bergbaus K: Parenchymal and vascular endothelial cell injury in the hypoxic and reperfused rat liver: Evidence for superoxide anion generation by perfusion with ferricytochrome c. Biomed Pharmacother 47:213-218, 1993.
3. Biasi F, Chiarpotto E, Lafranco G, et al: Oxidative stress in the development of human ischemic hepatitis during circulatory shock. Free Radical Biol Med 17:225-233, 1994.
4. Marzi I, Rose S, Bühren V: Prävention des Multiorganversagens nach Trauma durch Einsatz des Sauerstoffradikalscavengers rh-Superoxid Dismutase. Intensivmed 28:443, 1991 (abstract).
5. Sauberlich HE: Pharmacology of vitamin C. Annu Rev Nutr 14:371-391, 1994 (abstract).
6. Kaufman MJ: Comparison of the free radical-scavenging ability of captopril and ascorbic acid in an in-vitro model of lipid oxidation: implications for reperfusion injury and ACE inhibitor therapy. J Pharm Pharmacol 46:217-220, 1994.
7. Lehr HA, Frei B, Arfors KE: Vitamin C prevents cigarette smoke-induced leukocyte aggregation, adhesion to endothelium in vivo. Proc Natl Acad Soc USA 91:7688-7692, 1994.
8. Ozaki M, Fuchinoue S, Teraoka S, Ota K: The in vivo cytoprotection of ascorbic acid against ischemia reoxygenation injury of rat liver. Arch Biochem Biophys 318:439-445, 1995.
9. Ekman T, Bagge U, Risberg B, Soussi B: Ascorbate preserves gastric mucosal metabolism and microcirculation after hemorrhagic shock and retransfusion in rats. Eur Surg Res 27:39-48, 1995.
10. Degroot H: Reactive oxygen species in tissue injury. Hepato-Gastroenterology 41:328-332, 1994.
11. Vanjaarsveld H, Kuyl JM, Alberts DW, Wild MN: Antioxidant supplementation partially protects against myocardial mitochondrial ischemia/ reperfusion injury, but ascorbate in the perfusate prevented the beneficial effect. Res Commun Mol Pathol Pharmacol 85:33-44, 1994.
12. Younes M, Kayser E, Strubelt O: Effect of antioxidants on hypoxia/ reoxygenation-induced injury in isolated perfused rat liver. Pharmacol Toxicol 71:278-283, 1992.
13. Suzuki K, Ota H, Sasagawa S, Sakatani T, Fujikura T: Assay method for myeloperoxidase in human polymorphnuclear leukocytes. Anal Biochem 132:345-352, 1983.
14. Minor T, Yamaguchi T, Isselhard W: Treatment of preservation reperfusion injury by platelet-activating factor antagonism in the rat liver graft. Transplant Proc 27:522-523, 1995.
15. Wong SHY, Knight JA, Hopfer SM, Zahria O, Leach CNJ, Sunderman FW: Lipoperoxides in plasma as measured by liquid chromatographic separation of malondialdehyde-thiobarbituric acid adduct. Clin Chem 33: 214-220, 1987.
16. Minor Th, Sturz J, Klauke H, Isselhard W: Reduction of oxidative tissue injury and endothelial dysfunction by graduated reperfusion after cardioplegic arrest in isolated rat hearts. Free Radical Biol Med 18:621-626, 1995.
17. Kobelt F, Schreck U, Henrich A: Involvement of liver in the decompensation of hemorrhagic shock. Shock 2:281-288, 1994.
18. Vollmar B, Menger MD, Lang G, Post S, Messmer K: Hepatic microcirculation in hemorrhagic shock. Prog Appl Microcirc 19:85-105, 1993.
19. Minor Th, Isselhard W, Kunz G, Saad S: Involvement of oxygen in harvesting injury of the liver: An experimental study including substrate-free organ persufflation to evaluate a specific therapeutic approach. Res Exp Med 191:167-175, 1991.
20. Tan S, Yokoyama Y, Dickens E, Cash TG, Freeman BA, Parks DA: Xanthine oxidase activity in the circulation of rats following hemorrhagic shock. Free Radical Biol Med 15:407-414, 1993.
21. Haglind E, Xia GC, Rylander R: Effects of antioxidants and PAF receptor antagonist in intestinal shock in the rat. Circ Shock 42:83-91, 1994.
22. Jaeschke H: Mechanisms of oxidant stress-induced acute tissue injury. Proc Soc Exp Biol Med 209:104-111, 1995.
23. Jaeschke H, Farhood A, Smith CW: Neutrophils contribute to ischemia/ reperfusion injury in rat liver in vivo. FASEB J 4:3355-3359, 1990.
24. Zhang JX, Jones DV, Clemens MG: Effect of activation on neutrophil-induced hepatic microvascular injury in isolated rat liver. Shock 1:273-278, 1994.
25. Marzi I, Bauer M, Secchi A, Bahrami S, Redl H, Schlag G: Effect of anti-tumor necrosis factor alpha on leukocyte adhesion in the liver after hemorrhagic shock: An intravital microscopic study in the rat. Shock 3:27-33, 1995.