Structure-activity analysis of fluorinated 1-N-arylamino-1-arylmethanephosphonic acid esters as inhibitors of the NADH:ubiquinone oxidoreductase (complex I)

Journal of Computer-Aided Molecular Design

Volumn 10, Issue 2, 1996, Pages 100-106

  Dronia, H ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

1 N Arylamino 1 arylmethanephosphonic acid ester; Inhibitor; Molecular modelling; NADH:Ubiquinone oxidoreductase (complex I)

Indexed keywords

ELECTRONIC PROPERTIES;

1-N-ARYLAMINO-1-ARYLMETHANEPHOSPHONIC ACID ESTER; ACID ESTER; ACTIVITY ANALYSIS; INHIBITOR; INHIBITORY EFFECT; NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I); OXIDO-REDUCTASES; STRUCTURAL AND ELECTRONIC PROPERTIES; STRUCTURE ACTIVITY; UBIQUINONE;

ESTERS;

ENZYME INHIBITOR; ORGANOPHOSPHORUS COMPOUND; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE);

ANIMAL; ARTICLE; BINDING SITE; CATTLE; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; COMPUTER PROGRAM; COMPUTER SIMULATION; CONFORMATION; DRUG ANTAGONISM; ELECTROCHEMISTRY; ENZYMOLOGY; HEART MITOCHONDRION; METABOLISM; OXYGEN CONSUMPTION; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; CATTLE; COMPUTER SIMULATION; ELECTROCHEMISTRY; ENZYME INHIBITORS; MITOCHONDRIA, HEART; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; NAD(P)H DEHYDROGENASE (QUINONE); ORGANOPHOSPHORUS COMPOUNDS; OXYGEN CONSUMPTION; PROTEIN CONFORMATION; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030123919     PISSN: 0920654X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00402818     Document Type: Article

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