Both IgG- and C1q-Receptors Play a Role in the Enhanced Binding of IgG Complexes to Human Mesangial Cells

Journal of the American Society of Nephrology

Volumn 7, Issue 4, 1996, Pages 573-581

  Van Den Dobbelsteen, Marieke E A ^a   Van Der Woude, Fokko J ^a   Schroeijers, Willeke E M ^a   Klar Mohamad, Ngaisah ^a   Van Es, Leendert A ^a   Daha, Mohamed R ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Complement; Immune complexes; Kidney; Mesangial cells; Receptors

Indexed keywords

C1QBP PROTEIN, HUMAN; CARRIER PROTEIN; COMPLEMENT 1Q RECEPTOR; COMPLEMENT COMPONENT C1Q; COMPLEMENT RECEPTOR; FC RECEPTOR; HERMES ANTIGEN; IMMUNOGLOBULIN G; IODINE; MEMBRANE PROTEIN; MITOCHONDRIAL PROTEIN; MONOCLONAL ANTIBODY;

ANTIGEN ANTIBODY COMPLEX; ARTICLE; BINDING SITE; CELL CULTURE; HUMAN; IMMUNOLOGY; MESANGIUM; METABOLISM; PROTEIN BINDING; SERODIAGNOSIS;

ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY COMPLEX; ANTIGENS, CD44; BINDING SITES; CARRIER PROTEINS; CELLS, CULTURED; COMPLEMENT C1Q; GLOMERULAR MESANGIUM; HUMANS; IMMUNOGLOBULIN G; IODINE ISOTOPES; MEMBRANE GLYCOPROTEINS; MITOCHONDRIAL PROTEINS; PRECIPITIN TESTS; PROTEIN BINDING; RECEPTORS, COMPLEMENT; RECEPTORS, IGG;

EID: 0030120348     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/asn.v74573     Document Type: Article

References (41)

1. Porter KA, Pugh RCB. The urinary tract. In: Systemic Pathology. London: Churchill Livingstone; 1992:125-217.
2. Glassock RJ, Adler SG, Ward HJ, Cohen AH. Primary glomerular diseases. In: Brenner BM, Porter KA, Eds. The Kidney. 4th Ed. Philadelphia: W.B. Saunders; 1991: 1182-1279.
3. Santiago A, Satriano J, DeCandido S, et al.: A specific Fey receptor on cultured rat mesangial cells. J Immunol 1989;143:2575-3582.
4. Sedor J, Carey SW, Emancipator SN: Immune complexes bind to cultured rat glomerular mesangial cells to stimulate Superoxide release. Evidence for an Fc receptor. J Immunol 1987;138:3751-3757.
5. Knauss TC, Mene P, Ricanati SA, et al.: Immune complex activation of rat glomerular mesangial cells: Dependence on the Fc region of the antibody. Am J Physiol 1989;257:F478-F485.
6. 2 and platelet activating factor formation by cultured rat mesangial cells. J Clin Invest 1988;82:936-944.
7. Hora K, Satriano JA, Santiago A, et al.: Receptors for IgG complexes activate synthesis of monocyte chemoattractant peptide 1 and colony-stimulating factor 1. PNAS 1992;89:1745-1749.
8. van den Dobbelsteen MEA, van der Woude FJ, Schroeijers WEM, van Es LA, Daha MR: Soluble aggregates of IgG and immune complexes enhance IL-6 production by renal mesangial cells. Kidney Int 1993;43:544-553.
9. Daha MR, Miltenburg AMM, Hiemstra PS, Klar-Mohamad N, Van Es LA, Van Hinsbergh VWM: The complement subcomponent C1Q mediates binding of immune complexes and aggregates to endothelial cells in vitro. Eur J Immunol 1988;18:783-787.
10. Veerhuis R, Van Es LA, Dana MR: Effects of soluble aggregates of IgG on the binding, uptake and degradation of the C1Q subcomponent of complement by adherent guinea pig peritoneal macrophages. Eur J Immunol 1985;15:881-887.
11. Kijlstra A, Van Es LA, Daha MR: Enhanced degradation of soluble immunoglobulin aggregates by macrophages in the presence of complement. Immunol 1979;37:673-680.
12. Ghebrehivet B: C1Q receptor. Methods Enzym 1987: 150:558-578.
13. Tenner AJ, Cooper NR: Identification of types of cells in human peripheral blood that bind C1Q. Immunol 1981; 126:1174-1179.
14. van den Dobbelsteen MEA, van der Woude FJ, Schroeijers WEM, Klar-Mohamad N, van Es LA, Daha MR: C1Q, a subunit of the first component of complement, enhances the binding of aggregated IgG to rat renal mesangial cells. J Immunol 1993;151:4315-4324.
15. Hoekzema R, Martens M, Brouwer MC, Hack EC: The distorative mechanism for the activation of complement component C1 supported by studies with a monoclonal antibody against the "arms" of C1Q. Molec Immunol 1988;25:485-494.
16. Daha MR, Van den Berg RH, Dunn L, Muizert-de Lange YM, Gerritsen A, Van Es LA: Isolation and function of the human endothelial cell C1Q receptor (C1qR). Mediators of Inflamm 1993:2:447-452.
17. Miltenburg AAM, Meyer-Paape ME, Daha MR, Paul LC: Inhibition of T-cell cytolytic potential by Concavalin A: A result of activation? Scand J Immunol 1987;26:555-561.
18. Striker GE, Striker LJ: Biology of disease. Glomerular cell culture. Lab Invest 1985;53:122-131.
19. Muller EW, Kim AE, Vernier GK, van der Hem GK, van der Woude FJ: Explantation of mesangial cell "hillocks": A method for obtaining human mesangial cells in culture. Int J Exp Path 1992;73:9-20.
20. van den Dobbelsteen MEA, Verhasselt V, Kaashoek JGJ, et al.: Regulation of C3 and factor H synthesis of human glomerular mesangial cells by interleukin-1 and interferon-γ. Clin Exp Immunol 1994;95:173-180.
21. Bogers WMJM, Stad RK, Janssen DJ, Van Rooijen N, Van Es LA, Daha MR: Kupffer cell depletion in vivo results in preferential elimination of IgG aggregates and immune complexes via specific Fc receptors on rat endothelial cells. Clin Exp Immunol 1991;86:328-333.
22. Parham P. Preparation and purification of active fragments from mouse monoclonal antibodies. In: Weir DM, Ed. Cellular Immunology. 4th Ed. Edinburgh: Churchill Livingstone; 1986:1:517-521.
23. Tenner AJ, Lesavre PH, Cooper NR: Purification and radiolabeling of human C1Q. J Immunol 1981;127:648-653.
24. Kolb WP, Kolb LM, Podack ER: C1Q: Isolation from human serum in high yield by affinity chromatography and development of a highly sensitive hemolytic assay. J Immunol 1979;122:2103-2111.
25. Daha MR, Klar N, Hoekzema R, van Es LA: Enhanced IgG production by human peripheral lymphocytes induced by aggregated C1Q. J Immunol 1990;144:1227-1232.
26. 2 tetrameres. Molec Immunol 1983; 20:53-66.
27. Abo T, Balsch CM: A differentiation antigen of human NK and K cells identified by a monoclonal antibody HNK-1. J Immunol 1980;127:1024-1029.
28. Van de Winkel JGJ, Anderson CL: Biology of human immunoglobulin G Fc receptors. J Leukocyte Biol 1991; 49:511-524.
29. Miedema F, Tetteroo PAT, Hesslink WG, Werner G, Spits H, Melief CJM: Eur J Immunol 1984 14:518-523.
30. Scatchard G: The attractions of proteins for small molecules and ions. Ann NY Acad Sci 1949;51:660-672.
31. Morcos M, Schönermark M, Heckl-Östreicher, Hänsch GM, Rother K: Expression of the "NK-type" Fc-gamma III receptor (CD 16) on human glomerular mesangial cells (GMC) in culture and stimulation by anti-CD 16 or aggregated immunoglobulin [Abstract]. J Am Soc Nephrol 1992;3:605A.
32. Radeke HH, Gessner JE, Uciechowski P, Magert HJ, Schmidt RE, Resch K: Intrinsic human glomerular mesangial cells can express receptors for IgG complexes (hFcγRIII-A) and the associated FcεRI γ-chain. J Immunol 1994;153:1281-1292.
33. Kazatchkine MD, Fearon DT, Appay AD, Manel C, Bariety J: Immunohistochemical study of the human glomerular C3b receptor in normal kidney and in seventy-five cases of renal diseases. J Clin Invest 1982;69:900-912.
34. Ghebrehivet B, Silvestri L, McDevitt C: Identification of the Raji cell membrane-derived C1Q inhibitor as a receptor for human C1Q. J Exp Med 1984;160:1375-1389.
35. Malhotra R, Sim RB: Chemical and hydrodynamic characterization of the human leucocyte receptor for complement subcomponent C1Q. Biochem J 1989;262:625-631.
36. Guan E, Burgess WH, Robinson SL, Goodman EB, McTigue KJ, Tenner AJ: Phagocytic cell molecules that bind the collagen like region of C1Q. Involvement in the C1Q-mediated enhancement of phagocytosis. J Biol Chem 1991;266:20345-20355.
37. Bing DH, Almeda S, Isliker H, Hynes RO: Fibronectin binds to the C1Q component of complement. Proc Natl Acad Sci USA 1982;79:4198-4201.
38. Cosio FG, Sedmak DS, Nahman NS: Cellular receptors for matrix proteins in normal human kidney and human mesangial cells. Kidney Int 1990;38:886-895.
39. Tenner AJ, Cooper NR: Analysis of receptor-mediated C1Q binding to human peripheral blood mononuclear cells. J Immunol 1980;125:1658-1663.
40. Bobak DA, Gaither TA, Frank MM, Tenner AJ: Modulation of FcR function by complement: Subcomponent C1Q enhances phagocytosis of IgG opsonized targets by human monocytes and culture-derived macrophages. J Immunol 1987;138:1150-1156.
41. Knutson DW, Kijlstra A, van Es LA: Association and dissociation of aggregated IgG from rat peritoneal macrophages. J Exp Med 1977;145:1368-1381.