Update on the concepts and probable role of peptidergic nerves in dentine sensitivity and pain mechanisms

East African Medical Journal

Volumn 73, Issue 4, 1996, Pages 268-270

  Ngassapa, D N ^a  

^a UNIVERSITY OF DAR ES SALAAM   (Tanzania)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; SUBSTANCE P; VASOACTIVE INTESTINAL POLYPEPTIDE;

DENTIN; DENTIN SENSITIVITY; HUMAN; INNERVATION; MYELINATED NERVE; NERVE FIBER; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW;

CALCITONIN GENE-RELATED PEPTIDE; DENTIN; DENTIN SENSITIVITY; HUMANS; NERVE FIBERS; NERVE FIBERS, MYELINATED; SUBSTANCE P; VASOACTIVE INTESTINAL PEPTIDE;

EID: 0030120336     PISSN: 0012835X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (29)

1. Byers, M. R. and Matthews, B. Autoradiographic demonstration of ipsilateral and contralateral sensory nerve endings in cat dentine, pulp and periodontium. Anat. Rec. 1981; 201:249-260
2. Mumford, J.M. Orofacial Pain. Aetiology, Diagnosis and Treatment, 3rd Ed. Churchill Livingstone, Edinburgh, 1982.
3. Holland, G. R. and Robinson, P. The canine and size of axons at the apex of the cat's canine tooth. Anat. Rec. 1983; 205:215-222
4. Dahl, E. and Mjor, I. A. The structure and distribution on nerves in the pulp-dentine organ. Acta Odont. Scand. 1973; 31:349-354
5. Byers, M. R. Dental sensory receptors. Int. Rev. Neurobiol. 1984; 25:39-94
6. Olgart, L., Hokfelt, T., Nilsson, G. and Pernon, B.Localization of substance P-like imnunoreactivity in nerves in the pulp tooth Pain 1977; 4:153-159.
7. Wakisaka, S., Ichikawa, H., Nishimoto, T., Matsuo, S., Yamamoto, K., Nakata, T. and Akai, M. Substance P-like immunoreactivity in the pulp-dentine zone of human molar teeth demonstrated by indirect immunofluorescence. Arch Oral Biol. 1984; 29:73-75.
8. Wakisaka, S., Akai, M., Takano, Y., Ichikawa, H., Nishikawa, S., Uchiyama, T. and Matsuo, S. Distribution of peptidergic nerve fibres in the walls of blood vessels in the feline dental pulp. Jap. J. Oral Biol. 1985; 27:1202-1209.
9. Wakisaka, S., Ichikawa, S., Matsuo, S., Takamo, Y. and Akai, M. The distribution and origin of calcitonin gene-related peptide-containing nerve fibres in the feline dental pulp. Histochem. 1987; 86:585-589.
10. Gazelius, B., Olgart, L. and Edwall, L. Effect of substance P on sensory nerves and blood flow in the feline dental pulp. In: D.J. Anderson, B. Matthews (Eds). Pain in the trigeminal region pp 95-101 Elsevier, North Holland Biomedical Press, Amsterdam 1977.
11. Wall, P. D. and Fitzgerald, M. If substance P fails to fulfil the criteria as a neurotransmitter in somatosensory afferents, what might be its function? In: Substance P in the nervous system. CIBA Foundation Symposium, pp 249-261 (Eds) R Porter and M O O'Connor, Pittman, London 1982
12. Narhi, M. and Hirvonen, T. Functional changes in the cat pulp nerve activity after thermal and mechanical injury of the pulp. Proc. Finn. Dent. Soc. 1983; 79:162-167.
13. Lembeck, F. and Holzer, P. Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation. Naumy-Sch. Arch. Pharmacol. 1979; 310:175-183.
14. Silverman, J. D., Sampogna, S. L. and Kruger, L. Calcitonin gene-related peptide immunoreactivity (CGRP-IR) demonstrated in nerve fibres of rat dental pulp. Anat. Rec. 1986; 214:122A
15. Uddman, R., Grunditz, T. and Sundler, F. Calcitonin gene-related peptide: A sensory transmitter in dental pulps. Scand.J. Dent. Res. 1986; 94:219-224.
16. Ngassapa D. Dentine sensitivity: Factors influencing intradental nerve activation in dog teeth. Thesis Univ. of Kuopio 1991.
17. Byers, M. R., Taylor, P. E., Khayat, B. G. and Kimberly, C. H. Effect of injury and inflammation on pulpal and periapical nerves J. Endod. 1990; 16: 78-84.
18. Silverman, J. and Kruger, J. An interpretation of dental innervation based upon the pattern of Calcitonin gene-related (CGRP) immunoreactive thin sensory axons. Somatosens. Res. 1987; 5:157-175.
19. Kimberly, C. L. and Byers, M. R. Inflammation of rat molar pulp and periodontium causes increased calcitonin gene-related peptide and axonal sprouting. Anat. Rec. 1988; 222:289-300.
20. Taylor, P. E., Byers, M. R. and Redd, P. E. Sprouting of CGRP nerve fibres in response to dentine injury in rat molars. Brain Res. 1988; 461:371-376.
21. Franco-Cereceda, A. Henke, H. Lundberg, J. M. Petermann, J. B. Hokfelt, T. and Fischer, J. A. Calcitonin gene-related peptide (CGRP)in capsaicin-sensitive substance P-immunoreactive sensory neurones in animals and man: distribution and release by capsaicin. Peptides 1987; 8:399-410.
22. Skofitsch, G. and Jacobwitz, D. M. Calcitonin gene-related peptide: Detailed immunohistochemical distribution in the central nervous system. Peptides 1985; 6:721-745.
23. Brain, S. D., Williams, T. J., Tippins, J.R., Morris, H.R. and McIntire, I. Calcitonin gene-related peptide is a potent vasodilator. Nature 1985; 313:54-56.
24. Zaidi, M., Bevis, P.J.R., Girgis, S.I., Lynch, C., Stevenson, J.C. and MacIntyre I. Circulating CGRP comes from the perivascular nerves. Eur. J. Pharmacol. 1985; 117:283-284.
25. Gazelius, B., Edwall, B., Olgart, L., Lundberg, J.M., Hokfelt, T. and Fisher, J.A. Vasodilatory effects and coexistence of calcitonin gene-related peptide (CGRP) and substance P in sensory nerves of cat dental pulp. Acta Physiol. Scand. 1987; 130: 33-40.
26. LeGreves, P.E., Nyberg, F., Terenius, L. and Hokfelt, T. Calcitonin gene-related peptide is a potent inhibitor of substance P degradation. Eur. J. Pharmacol. 1985; 115:309-311.
27. Said, S.I. and Mutt, V. Polypeptide with broad biological activity. Isolation from small intestine. Science NY. 1970; 169:1217-1218.
28. Larsson, L.I. Ultrastructural localization of a new neuronal peptide (VIP). Histochem. 1977; 54:153-176.
29. Iggo, A. Pain receptors. In: Recent advances on pain. Pathophysiology and clinical aspects Procacci and C. Charles pp 3-35 J. Bonica, P. Eds. Thomas Publisher, Springfield, Illinois, 1977.