Haemophilus influenzae: Capsule vaccine and capsulation genetics

Molecular Medicine Today

Volumn 2, Issue 4, 1996, Pages 160-165

  Kroll, J Simon ^a   Booy, Robert ^a  

^a ST MARY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HAEMOPHILUS INFLUENZAE;

BACTERIAL POLYSACCHARIDE; HAEMOPHILUS INFLUENZAE TYPE B POLYSACCHARIDE VACCINE; HAEMOPHILUS VACCINE;

ANIMAL; BACTERIAL INFECTION; BACTERIAL MEMBRANE; CHILD; GENETICS; HAEMOPHILUS INFLUENZAE; HUMAN; IMMUNOLOGY; INFANT; PATHOGENICITY; PRESCHOOL CHILD; PREVENTIVE HEALTH SERVICE; REVIEW; VIRULENCE;

ANIMALS; BACTERIAL CAPSULES; CHILD; CHILD, PRESCHOOL; HAEMOPHILUS INFECTIONS; HAEMOPHILUS INFLUENZAE; HAEMOPHILUS VACCINES; HUMANS; IMMUNIZATION PROGRAMS; INFANT; POLYSACCHARIDES, BACTERIAL; VIRULENCE;

EID: 0030119567     PISSN: 13574310     EISSN: None     Source Type: Journal    
DOI: 10.1016/1357-4310(96)88791-0     Document Type: Review

References (37)

1. Gellert, G.A., Wenger, J.D. and Brilla, A. (1994) Haemophilus influence type b disease in Latvia, Lancet 344, 959
2. Clements, D.A. et al. (1993) Comparison of the epidemiology and cost of Haemophilus influenzae type b disease in five western countries, Pediatr. Infect. Dis. J. 12, 362-367
3. Ward, J.I. et al. (1981) Haemophilus influenzae disease in Alaskan Eskimos: characteristics of a population with an unusual incidence of invasive disease, Lancet i, 1281-1285
4. Powell, M. et al. (1992) Antimicrobial resistance in Haemophilus influenzae from England and Scotland in 1991, J. Antimicrob. Chemother. 29, 547-554
5. Turk, D.C. (1982) Clinical importance of Haemophilus influenzae - 1981, in Haemophilus influenzae. Epidemiology, Immunology, and Prevention of Disease (Sell, S.H. and Wright, P.F., eds) Elsevier
6. Moxon, E.R. and Kroll, J.S. (1990) The role of bacterial polysaccharide capsules as virulence factors, in Current Topics in Microbiology and Immunology 150: Bacterial Capsules (Jann, K. and Jann, B., eds) Springer-Verlag
7. Peltola, H., Kayhty, H., Sivonen, A. and Makela, H. (1977) Haemophilus influenzae type b capsular polysaccharide vaccine in children: a double-blind field study of 100,000 vaccinees 3 months to 5 years of age in Finland, Pediatrics 60, 730-737
8. Booy, R. et al. (1994) Efficacy of Haemophilus influenzae type b conjugate vaccine PRP-T, Lancet 344, 362-366
9. Anon. (1994) Invasive Haemophilus influenzae infections: changing patterns, Communicable Disease Report 4, 227-230
10. Takala, A.K. et al. (1991) Reduction of oropharyngeal carriage of Haemophilus influenzae type b (Hib) in children immunized with a Hib conjugate vaccine, J. Infect. Dis. 164, 982-986
11. Takala, A.K. et al. (1993) Vaccination with Haemophilus influenzae type b meningococcal protein conjugate vaccine reduces oropharyngeal carriage of Haemophilus influenzae type b among American Indian children, Pediatr. Infect. Dis. J. 12, 593-599
12. Barbour, M.L. et al. (1993) Haemophilus influenzae type b carriage and immunity four years after receiving the Haemophilus influenzae oligosaccharide-CRM197 (HbOC) conjugate vaccine, Pediatr. Infect. Dis. J. 12, 478-484
13. Kauppi, M., Saarinen, L. and Kayhty, H. (1993) Anti-capsular polysaccharide antibodies reduce nasopharyngeal colonization by Haemophilus influenzae type b in infant rats, J. Infect. Dis. 167, 365-371
14. Teare, E.L., Fairley, C.K., White, J. and Begg, N.T. (1994) Efficacy of Hib vaccine, Lancet 344, 828-829
15. Foster, J.A. and McGowan, K.L. (1994) Rising rate of pneumococcal bacteremia at the Children's Hospital of Philadelphia, Pediatr. Infect. Dis. J. 13, 1143-1144
16. Baer, M., Vuento, R. and Vesikari, T. (1995) Increase in bacteraemic pneumococcal infections in children, Lancet 345, 661
17. Booy, R. et al. (1995) Invasive pneumococcal infections in children, Lancet 345, 1245-1246
18. Zwahlen, A., Kroll, J.S., Rubin, L.G. and Moxon, E.R. (1989) The molecular basis of pathogenicity in Haemophilus influenzae: comparative virulence of genetically related capsular transformants and correlation with changes at the capsulation locus cap, Microb. Pathogen. 7, 225-235
19. Musser, J.M. et al. (1990) Global genetic structure and molecular epidemiology of encapsulated Haemophilus influenzae, Rev. Infect. Dis. 12, 75-111
20. Kroll, J.S. and Moxon, E.R. (1990) Capsulation in distantly related strains of Haemophilus influenzae type b: genetic drift and gene transfer at the capsulation locus, J. Bacteriol. 172, 1374-1379
21. Frosch, M. et al. (1991) Evidence for a common molecular origin of the capsule gene loci in Gram-negative bacteria expressing group II capsular polysaccharides, Mol. Microbiol. 5, 1251-1263
22. Roberts, I.S. et al. (1988) Common organization of gene clusters for production of different capsular polysaccharides (K antigens) in Escherichia coli, J. Bacteriol. 170, 1305-1310
23. Kroll, J.S., Zamze, S., Loynds, B. and Moxon, E.R. (1989) Common organization of chromosomal loci for the production of different capsular polysaccharides in Haemophilus influenzae, J. Bacteriol. 171, 3343-3347
24. Van Eldere, J. et al. (1995) Region II of the Haemophilus influenzae type b capsulation locus is involved in serotype-specific polysaccharide synthesis, Mol. Microbiol. 15, 107-118
25. Kroll, J.S., Loynds, B.M. and Moxon, E.R. (1991) The Haemophilus influenzae capsulation gene cluster: a compound transposon, Mol. Microbiol. 5, 1549-1560
26. Danner, D.B., Deich, R.A., Sisco, K.L. and Smith, H.O. (1980) An 11-base-pair sequence determines the specificity of DNA uptake in Haemophilus transformation, Gene 11, 311-318
27. Anderson, R.P. and Roth, J.R. (1977) Tandem genetic duplications in phage and bacteria, Annu. Rev. Microbiol. 31, 473-505
28. Hoiseth, S.K., Moxon, E.R. and Silver, R.P. (1986) Genes involved in Haemophilus influenzae type b capsule expression are part of an 18-kb tandem duplication, Proc. Natl Acad. Sci. USA 83, 1106-1111
29. Kroll, J.S. and Moxon, E.R. (1988) Capsulation and gene copy number at the cap locus of Haemophilus influenzae type b, J. Bacteriol. 170, 859-864
30. Kroll, J.S., Hopkins, I. and Moxon, E.R. (1988) Capsule loss in H. influenzae type b occurs by recombination-mediated disruption of a gene essential for polysaccharide export, Cell 5, 347-356
31. - transition in Haemophilus influenzae type b, J. Gen. Microbiol. 137, 2571-2576
32. Kroll, J.S., Moxon, E.R. and Loynds, B.M. (1993) An ancestral mutation enhancing the fitness and increasing the virulence of Haemophilus influenzae type b, J. Infect. Dis. 168, 172-177
33. Leaves, N.I., Falla, T.J. and Crook, D.W.M. (1995) The elucidation of novel capsular genotypes of Haemophilus influenzae type b with the polymerase chain reaction, J. Med. Microbiol 43, 120-124
34. Ely, S., Tippett, J., Kroll, J.S. and Moxon, E.R. (1986) Mutations affecting expression and maintenance of genes encoding the serotype b capsule of Haemophilus influenzae, J. Bacteriol. 167, 44-48
35. Corn, P.G. et al. (1993) Genes involved in Haemophilus influenzae type b capsule expression are frequently amplified, J. Infect. Dis. 167, 356-364
36. Kroll, J.S., Moxon, E.R. and Loynds, B.M. (1994) Natural genetic transfer of a putative virulence-enhancing mutation to Haemophilus influenzae type a, J. Infect. Dis. 169, 676-679
37. Leach, A.J. et al. (1994) Bacterial colonization of the nasopharynx predicts very early onset and persistence of otitis media in Australian aboriginal infants, Pediatr. Infect. Dis. J. 13, 983-989