Influence of low-dose aprotinin on the inflammatory reaction due to cardiopulmonary bypass in children

Annals of Thoracic Surgery

Volumn 61, Issue 4, 1996, Pages 1205-1211

  Seghaye, Marie Christine ^a   Duchateau, Jean ^b   Grabitz, Ralph G ^b   Jablonka, Karsten ^b   Wenzl, Tobias ^b   Marcus, Christiane ^b   Messmer, Bruno J ^b   Von Bernuth, Goetz ^b  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

APROTININ; HEMOSTATIC AGENT; SERINE PROTEINASE INHIBITOR;

ANALYSIS OF VARIANCE; ARTICLE; BLOOD; CARDIOPULMONARY BYPASS; CHILD; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; HUMAN; INFANT; INFLAMMATION; INSTRUMENTATION; METHODOLOGY; NONPARAMETRIC TEST; POSTOPERATIVE CARE; PRESCHOOL CHILD; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; STATISTICS;

ANALYSIS OF VARIANCE; APROTININ; CARDIOPULMONARY BYPASS; CHILD; CHILD, PRESCHOOL; DOSE-RESPONSE RELATIONSHIP, DRUG; HEMOSTATICS; HUMANS; INFANT; INFLAMMATION; POSTOPERATIVE CARE; PROSPECTIVE STUDIES; SERINE PROTEINASE INHIBITORS; STATISTICS, NONPARAMETRIC;

EID: 0030119292     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/0003-4975(96)00013-6     Document Type: Article

References (20)

1. Butler J, Rocker GM, Westaby S. Inflammatory response to cardiopulmonary bypass. Ann Thorac Surg 1993;55:552-9.
2. Moat NE, Rebuck N, Shore DF, Evans TW, Finn AHR. Humoral and cellular activation in a simulated extracorporeal circuit. Ann Thorac Surg 1993;56:1509-14.
3. Bidstrup BP, Harrison J, Royston D, Taylor KM, Treasure T. Aprotinin therapy in cardiac operations: a report on use in 41 cardiac centers in the United Kingdom. Ann Thorac Surg 1993;55:971-6.
4. Westaby S. Aprotinin in perspective. Ann Thorac Surg 1993;55:1033-41.
5. Van Oeveren W, Jansen NJG, Bidstrup BP, et al. Effects of aprotinin on hemostatic mechanisms during cardiopulmonary bypass. Ann Thorac Surg 1987;44:640-5.
6. Van Oeveren W, Harder MP, Roozendaal KJ, Eijsman L, Wildevuur CRH. Aprotinin protects platelets against the initial effect of cardiopulmonary bypass. J Thorac Cardiovasc Surg 1990;99:788-97.
7. Fritz H, Wunderer G. Biochemistry and applications of aprotinin, the kallikrein inhibitor from bovine organs. Arzneimittelforschung 1983;33:479-94.
8. Laurel M-TP, Ratnoff OD, Everson B. Inhibition of the activation of Hageman factor (factor XII) by aprotinin (Trasylol). J Lab Clin Med 1992;119:580-5.
9. Delage JM, Simard J, Lehner-Netsch G. The enhancement of the haemolytic activity of the first component of complement by Trasylol. Immunology 1976;31:601-6.
10. Blauhut B, Gross C, Necek S, Doran JE, Späth P, Lundsgaard-Hansen P. Effects of high-dose aprotinin on blood loss, platelet function, fibrinolysis, complement, and renal function after cardiopulmonary bypass. J Thorac Cardiovasc Surg 1991;101:958-67.
11. Law SKA, Reid KBM. Activation and control of the complement system. In: Male D, Rickwood D, eds. Complement. Oxford: IRL Press Limited, 1988:9-27.
12. Kozin F, Cochrane CG. The contact activation system of plasma: biochemistry and pathophysiology. In: Gallin JI, Goldstein IM, Snydermann R, eds. Inflammation: basic principles and clinical correlates. New York: Raven Press, 1988: 101-20.
13. Quiroga MM, Miyagishima R, Haendschen LC, Glovsky M, Martin BA, Hogg JC. The effect of body temperature on leukocyte kinetics during cardiopulmonary bypass. J Thorac Cardiovasc Surg 1985;90:91-6.
14. Seghaye MC, Duchateau J, Grabitz RG, et al. Complement activation during cardiopulmonary bypass in infants and children: relation to postoperative multiple system organ failure. J Thorac Cardiovasc Surg 1993;106:978-87.
15. Boldt J, Osmer C, Schindler E, Linke LC, Stertmann WA, Hempelmann G. Circulating adhesion molecules in cardiac operations: influence of high-dose aprotinin. Ann Thorac Surg 1995;59:100-5.
16. Burden AC, Stacey RL, Wood RFM, Bell PR. The effect of protease inhibitors on leukocyte migration inhibition to tuberculin extract (PPD). Immunology 1978;34:217-21.
17. Seghaye MC, Duchateau J, Grabitz RG, et al. Histamine liberation related to cardiopulmonary bypass in children: possible relation to transient postoperative arrhythmias. J Thorac Cardiovasc Surg (in press).
18. Heinrich PC, Castell JV, Andus T. Interleukin-6 and the acute phase response. Biochem J 1990;265:621-36.
19. Nijsten MWN, De Groot ER, Ten Duis HJ, Klasen HJ, Hack CE, Aarden LA. Serum levels of interleukin-6 and acute phase responses. Lancet 1987;II:921.
20. Dietrich W, Mössinger H, Spannagl M, et al. Hemostatic activation during cardiopulmonary bypass with different aprotinin dosages in pediatric patients having cardiac operations. J Thorac Cardiovasc Surg 1993;105:712-20.