The genetics of idiopathic generalized epilepsy: Implications for the understanding of its aetiology

Molecular Medicine Today

Volumn 2, Issue 4, 1996, Pages 173-179

  Sander, Thomas ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; CHROMOSOME MAP; FEMALE; GENERALIZED EPILEPSY; GENETIC PREDISPOSITION; GENETICS; HUMAN; INFANT; MALE; MOUSE; NEWBORN; REVIEW;

ANIMALS; CHROMOSOME MAPPING; EPILEPSY, GENERALIZED; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFANT; INFANT, NEWBORN; MALE; MICE;

EID: 0030116489     PISSN: 13574310     EISSN: None     Source Type: Journal    
DOI: 10.1016/1357-4310(96)88793-4     Document Type: Review

References (35)

1. Commission on Classification and Terminology of the International League Against Epilepsy (1989) Proposal for revised classification of epilepsies and epileptic syndromes, Epilepsia 30, 389-399
2. Berkovic, S.F., Reutens, D.C., Andermann, E. and Andermann, F. (1994) The epilepsies: specific syndromes or a neurobiological continuum? in Epileptic Seizures and Syndromes (Wolf, P., ed.), pp. 25-37, John Libbey
3. Buchhalter, J.R. (1993) Animal models of inherited epilepsy, Epilepsia 34 (Suppl. 3), 31-41
4. Blandfort, M., Tsuboi, T. and Vogel, F. (1987) Genetic counseling in the epilepsies, Hum. Genet. 76, 303-331
5. Plouin, P. (1992) Benign neonatal convulsions (familial and non-familial), in Epileptic Syndromes in Infancy, Childhood and Adolescence (2nd edn) (Roger, J. et al., eds), pp. 3-11, John Libbey
6. Greenberg, D.A., Durner, M. and Delgado-Escueta, A.V. (1992) Evidence for multiple gene loci in the expression of the common generalized epilepsies, Neurology 42 (Suppl. 5), 56-62
7. Lander, E.S. and Schork, N.J. (1994) Genetic dissection of complex traits, Science 265, 2037-2048
8. Leppert, M. et al. (1989) Benign familial neonatal convulsions linked to genetic markers on chromosome 20, Nature 337, 647-648
9. Ronen, G.M. et al. (1993) Seizure characteristics in chromosome 20 benign familial neonatal convulsions, Neurology 43, 1355-1360
10. Malafosse, A. (1992) Confirmation of linkage of benign neonatal familial convulsions to D20S19 and D20S20, Hum. Genet. 89, 54-58
11. Ryan, S.G. et al. (1991) Benign familial neonatal convulsions: evidence for clinical and genetic heterogeneity, Ann. Neurol. 29, 469-473
12. Lewis, T.B. et al. (1993) Genetic heterogeneity in benign familial neonatal convulsions: identification of a new locus on chromosome 8q, Am. J. Hum. Genet. 53, 670-675
13. Steinlein, O., Schuster, V., Fischer, C. and Haeussler, M. (1995) Benign familial neonatal convulsions: confirmation of genetic heterogeneity and further evidence for a second locus on chromosome 8q, Hum. Genet. 95, 411-415
14. 4 subunit (CHRNA4) to human chromosome 20q13.2-q13.3, Genomics 22, 493-495
15. Anderson, V.E. et al. (1995) Testing the hCHRNA4 gene as a candidate for benign familial neonatal convulsions, Epilepsia 36 (Suppl. 3), 7
16. Steinlein, O. (1992) Localization of a gene for the human low-voltage EEG on 20q and genetic heterogeneity, Genomics 12, 69-73
17. Phillips, H.A. et al. (1995) Localization of a gene for autosomal dominant nocturnal frontal lobe epilepsy to chromosome 20q13.2, Nat. Genet. 10, 117-118
18. 4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy, Nat. Genet. 11, 201-203
19. Janz, D. (1989) Juvenile myoclonic epilepsy, Cleveland Clin. J. Med. 56 (Suppl. 1), 23-33
20. Durner, M., Janz, D., Zingsem, J. and Greenberg, D.A. (1992) Possible association of juvenile myoclonic epilepsy with HLA-DRw6, Epilepsia 33, 814-816
21. Obeid, T. et al. (1994) Is HLA-DRw13 (w6) associated with juvenile myoclonic epilepsy in Arab patients? Epilepsia 35, 319-321
22. Greenberg, D.A. et al (1995) HLA-DR and DQ alleles show an association with JME compared to non-JME forms of idiopathic generalized epilepsy, Epilepsia 36 (Suppl. 4), 147
23. Greenberg, D.A. et al. (1988) Juvenile myoclonic epilepsy (JME) may be linked to the Bf and HLA loci on chromosome 6, Am. J. Med. Genet. 31, 185-192
24. Durner, M. et al. (1991) Localization of idiopathic generalized epilepsies on chromosome 6p in families ascertained through juvenile myoclonic epilepsy patients, Neurology 41, 1651-1655
25. Sander, T. et al. (1995) The phenotypic spectrum related to the human epilepsy susceptibility gene EJM1, Ann. Neurol. 38, 210-218
26. Greenberg, D.A. et al. (1995) The genetics of idiopathic generalized epilepsies of adolescent onset: differences between juvenile myoclonic epilepsy and epilepsy with random grand mal and with awakening grand mal, Neurology 45, 942-946
27. Whitehouse, W.P. et al. (1993) Linkage analysis of idiopathic generalized epilepsy (IGE) and marker loci on chromosome 6p in families of patients with juvenile myoclonic epilepsy: no evidence for an epilepsy locus in the HLA region, Am. J. Hum. Genet. 53, 652-662
28. Liu, A.W. et al. (1995) Juvenile myoclonic epilepsy locus in chromosome 6p21.2-p11: linkage to convulsions and electroencephalography trait, Am. J. Hum. Genet. 57, 368-381
29. Shinnar, S. and Moshé, S.L. (1991) Age specificity of seizure expression in genetic epilepsies, Epilepsy Res. 31 (Suppl. 4), 69-85
30. B receptor activation in absence seizures in lethargic (lh/lh) mice, Science 257, 398-401
31. Moshé, S.L. et al. (1994) Maturation and segregation of brain networks that modify seizures, Brain Res. 665, 141-146
32. Brusa, R. et al. (1995) Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice, Science 270, 1677-1680
33. Ben-Ari, Y. and Represa, A. (1990) Brief seizure episodes induce long-term potentiation and mossy fibre sprouting in the hippocampus, Trends Neurosci. 13, 312-318
34. Meencke, H-J. and Janz, D. (1984) Neuropathological findings in primary generalized epilepsy: a study of eight cases, Epilepsia 25, 8-11
35. LoTurco, J.J. et al. (1995) GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis, Neuron 15, 1287-1298