Interaction of electron leak and proton leak in respiratory chain of mitochondria - Proton leak induced by superoxide from an electron leak pathway of univalent reduction of oxygen

Science in China, Series C: Life Sciences

Volumn 39, Issue 2, 1996, Pages 168-178

  Liu, Shusen ^a   Jiao, Xuamnao ^a   Wang, Xiaoming ^b   Zhang, Li ^b  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

H+ 2e ratio; Mitochondria; Proton leak; Superoxide radical; Transmembrane potential

Indexed keywords

FREE RADICAL; OXYGEN; PROTON PUMP; SUPEROXIDE;

ANIMAL; ARTICLE; CELL MEMBRANE POTENTIAL; DRUG EFFECT; HEART MITOCHONDRION; MALE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; REPERFUSION INJURY; SPRAGUE DAWLEY RAT;

ANIMALS; FREE RADICALS; MALE; MEMBRANE POTENTIALS; MITOCHONDRIA, HEART; MYOCARDIAL REPERFUSION INJURY; OXYGEN; PROTON PUMPS; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDES;

EID: 0030116229     PISSN: 10069305     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Brunori, M., Rotilio, G., Biochemistry of oxygen radical species, Methods Enzyml., 1984, 105: 22.
2. Cross, A. R., Jones, C. T. G., Enzymatic mechanism of superoxide production, Biochem. Biophys. Acta, 1991, 1057 (3): 281.
3. Biveris, A., Turrens, J. F., Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria, Biochem. J., 1980, 191: 421.
4. Zhang, H., Jiao, X. M., Liu, S. S., The effect of ischemia and reperfusion on energy transductional function of rat heart mitochondria, Chinese J. Pathophysiology (in Chinese), 1993, 9(5): 561.
5. Emaus, R. K., Grunwald, R., Lemasters, J. J., Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties, Biochem. Biophys. Acta, 1986, 850: 436.
6. Nicholls, D. G., Bioenergetics: An Introduction to the Chemiosmotic Theory, London: AP. Inc. LTD, 1982, 33.
7. Halliwall, B., Gutteridge, J. M. C., Role of free radicals and catalytic metal ions in human disease: an overview, Methods Enzyml., 186: 1.
8. Brand, M. D., The proton leak across the mitochondrial inner membrane, Biochem. Biophys. Acta, 1990, 1018(2/3):128.
9. Lian, J. P., Liu, S. S., Fluorescence measurment of the membrane surface charge and surface pH of mitochondria upon energization, Act Biochem. Biophys. Sinica (in Chinese), 1989, 21(5): 27.
10. Liu, S. S., Xiong, J. W., Jiao, X. M., Evidence for ATP synthesis coupled with energizing protons on membrane surface of mitoplast upon succinate oxidation, in 7th European Bioenergetics Conference, EBEG Short Report, 1992, 7:104.
11. Nohl, H., Stolze, K., Is redox-cycling ubiquinone involved in mitochondria oxygen activation? Free Radical Res. Commun., 1992, 6(6): 409.
12. Liu, S. S., Wang, X. M., Molecular mechanism of ischemia-reperfusion injury to energy transduction in cardiac mitochondria, Plenary lecture in international symposium on heart research, Beijing, March 1992, J. Beijing Medical Univ., 1992, 24(2): 48.
13. +-ATPase in myocardial mitochondria with ischemia/reperfusion injury and protective effect of DS182, Chinese J. Pathophysiology, 1994, 10(7 suppl.): 674.