Interferon β-1b effects on cytokine mRNA in peripheral mononuclear cells in multiple sclerosis

Multiple Sclerosis

Volumn 1, Issue 5, 1996, Pages 262-269

  Byskosh, P V ^a   Reder, A T ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Interferon ; Interleukin 10 (IL 10); Leukemia inhibitory factor (LIF); MRNA; Multiple sclerosis; Tumor necrosis factor (TNF )

Indexed keywords

2',5' OLIGOADENYLATE SYNTHETASE; BETA INTERFERON; CYTOKINE; MESSENGER RNA;

ADULT; ARTICLE; DRUG EFFECT; FEMALE; GENETICS; HUMAN; MALE; METABOLISM; MONONUCLEAR CELL; MULTIPLE SCLEROSIS;

2',5'-OLIGOADENYLATE SYNTHETASE; ADULT; CYTOKINES; FEMALE; HUMANS; INTERFERON-BETA; LEUKOCYTES, MONONUCLEAR; MALE; MULTIPLE SCLEROSIS; RNA, MESSENGER;

EID: 0030112474     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1177/135245859600100502     Document Type: Article

References (29)

1. Reder AT, Arnason BGW. (1985) Immunology of multiple sclerosis. In: Vinken PJ, Bruyn GW, Klawans HL, Koetsier JC. Handbook of Clinical Neurology: Demyelinating Diseases, Elsevier Science Publishers: Amsterdam, pp. 337-395.
2. Maimone D, et al. (1991) Cytokine levels in the cerebrospinal fluid and sera of patients with multiple sclerosis. J Neuroimmunol 32: 67-74.
3. Rieckmann P, et al. (1994) Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis. Neurology 44: 1523-1526.
4. Sharief MK, Hentges R. (1991) Association between tumor necrosis factor-α and disease progression in patients with multiple sclerosis. N Engl J Med 325: 467-472.
5. Link J, et al. (1994) Increased transforming growth factor-β, interleukin-4, and interferon-γ in multiple sclerosis. Ann Neurol 36: 379-386.
6. Kennedy MK, et al. (1992) Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J Immunol 149: 2496-2505.
7. Khoury SJ, Hancock WW, Weiner HL. (1992) Oral tolerance to myeline, basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor β, interleukin 4, and prostaglandin E expression in the brain. J Exp Med 176: 1355-1364.
8. + suppressor cells of autoimmune encephalomyelitis respond to T cell receptor-associated determinants on effector cells by interleukin-4 secretion. Eur J Immunol 22: 1757-1763.
9. The IFN-Beta Multiple Sclerosis Study Group. (1993) Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind placebo-controlled trial. Neurology 43: 655-661.
10. Jacobs L, et al. (1994) Results of a phase III trial of intramuscular recombinant beta interferon as treatment for multiple sclerosis. Ann Neurol 36: 259.
11. The IFN-Beta Multiple Sclerosis Study Group. (1993) Interferon beta-1b is effective in relapsing-emitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 43: 662-667.
12. Arnason BGW, Reder AT. (1994) Interferons and multiple sclerosis. Clin Neuropharm 17: 495-547.
13. Panitch HS, Folus JS, Johnson KP. (1987) Recombinant beta interferon inhibits gamma interferon production in multiple sclerosis. Ann Neurol 22: 139A.
14. Noronha A, Toscas A, Jensen MA. (1993) Interferon β decreases T cell activation and interferon γ production in multiple sclerosis. J Neuroimmunol 46: 145-154.
15. Abu-Khabar KS, Armstrong JA, Ho M. (1992) Type I interferons (IFN-α and -β) suppress cytotoxin (tumor necrosis factor-α and lymphotoxin) production by mitogen-stimulated human peripheral blood mononuclear cells. J Leukoc Biol 52: 165-172.
16. Panitch HS, Folus JS, Johnson KP. (1989) Beta interferon prevents HLA class II antigen induction by gamma interferon in MS. Neurology 39 (Suppl 1): 171.
17. Barna BP, et al. (1989) Interferon-β impairs induction of HLA-DR antigen expression in cultured adult human astrocytes. J Neuroimmunol 23: 45-53.
18. Ransohoff RM, et al. (1991). Interferon-b specifically inhibits interferon-g-induced class II major histocompatibility complex gene transcription in a human astrocytoma cell line. J Neuroimmunol 33: 103-112.
19. Reder AT, et al. (1993) Astrocyte cytolysis by MHC class II-specific mouse T cell clones. Transplantation 56: 393-399.
20. Porrini AM, Gambi D, Reder AT. (1995) Interferon beta effects on interleukin-10 secretion. Mononuclear cell response to interleukin-10 is normal in multiple sclerosis patients. J Neuroimmunol 61: 27-34.
21. Shakir S, Byskosh PV, Reder AT. (1994) Interferon-β induces interleukin-10 mRNA in mononuclear cells (MNC). Neurology 44 (Suppl 2): A211-212.
22. Bongioanni MR, et al. (1994) High-dose recombinant-alpha-2a-interferon (IFNA) therapy modulates cytokine profiles in MS. J Neuroimmunol 54: 1-2.
23. Noronha A, Toscas A, Jensen MA. (1990) Interferon beta augments suppressor cell function in multiple sclerosis. Ann Neurol 27: 207-210.
24. Antel JP, et al. (1986) Activated suppressor cell dysfunction in chronic progressive multiple sclerosis. J Immunol 137: 137-141.
25. Chomczynski P, Sacchi N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159.
26. Xie W-Q, Rothblum LI. (1991) Rapid, small-scale RNA isolation from tissue culture cells. Bio Techniques 11: 324-327.
27. Karp CL, et al. (1993) In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma. J Clin Invest 91: 1644-1648.
28. Wang AM, et al. (1985) Molecular cloning of the complementary DNA for human tumor necrosis factor. Science 228: 149-154.
29. Nedwin GE, et al. (1985) Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization. Nucleic Acids Research 13: 6361-6373.