Novel non-nucleosidic building blocks for the preparation of multilabeled oligonucleotides

Bioconjugate Chemistry

Volumn 7, Issue 2, 1996, Pages 240-248

  Guzaev, Andrei ^a   Salo, Harri ^a   Azhayev, Alex ^a   Lönnberg, Harri ^a  

^a UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

BUILDING BLOCKES; DERIVATIZATIONS; HYBRIDISATION; PHOSPHORAMIDITES; PHOSPHOROTHIOATES; PROPERTY;

OLIGONUCLEOTIDES;

EID: 0030111395     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc9600067     Document Type: Article

References (11)

1. For reviews, see: (a) Uhlman, E., and Peyman, A. (1990) Antisense oligonucleotides: A new therapeutic principle Chem. Rev. 90, 543-584; (b) Goodchild, J. (1990) Conjugates of oligonucleotides and modified oligonucleotides: A review of their synthesis and properties. Bioconjugate Chem. 1, 165-187: (c) Beaucage, S. L. and Iyer, R. P. (1993) The functionalization of oligonucleotides via phosphoramidite derivatives. Tetrahedron 49, 1925-1963.
2. For reviews, see: (a) Uhlman, E., and Peyman, A. (1990) Antisense oligonucleotides: A new therapeutic principle Chem. Rev. 90, 543-584; (b) Goodchild, J. (1990) Conjugates of oligonucleotides and modified oligonucleotides: A review of their synthesis and properties. Bioconjugate Chem. 1, 165-187: (c) Beaucage, S. L. and Iyer, R. P. (1993) The functionalization of oligonucleotides via phosphoramidite derivatives. Tetrahedron 49, 1925-1963.
3. For reviews, see: (a) Uhlman, E., and Peyman, A. (1990) Antisense oligonucleotides: A new therapeutic principle Chem. Rev. 90, 543-584; (b) Goodchild, J. (1990) Conjugates of oligonucleotides and modified oligonucleotides: A review of their synthesis and properties. Bioconjugate Chem. 1, 165-187: (c) Beaucage, S. L. and Iyer, R. P. (1993) The functionalization of oligonucleotides via phosphoramidite derivatives. Tetrahedron 49, 1925-1963.
4. Bazin, H., Roget, A., and Teoule, R. (1991) Phosphoramidite reagents for the easy preparation of polylabeled oligonucleotide probes. Nucleosides Nucleotides 10, 363-366.
5. Teigelkamp, S., Ebel, S., Will, D. W., Brown, T., and Beggs, J. D. (1993) Branched polylabelled oligonucleotides: enchanced specificity of fork-shaped biotinylated oligoribonucleotides for antisense affinity selection. Nucleic Acids Res. 21, 4651-4652.
6. De Vos, M. J., Van Elsen, A., and Bollen, A. (1994) New non nucleosidic phosphoramidites for the solid phase multi-labeling of oligonucleotides: comb- and multifork-like structures. Nucleosides Nucleotides 13, 2245-2265.
7. Nelson, P. S., Sherman-Gold, R., and Leon, R. (1989) A new and versatile reagent for incorporating multiple primary aliphatic amines into synthetic oligonucleotide. Nucleic Acids Res. 17, 7179-7186.
8. Hébert, N., Davis, P. W., DeBaets, E. L., and Acevedo, O. L. (1994) Synthesis of N-substituted hydroxyprolinol phosphoramidites for the preparation of combinatorial libraries. Tetrahedron Lett. 35, 9509-9512.
9. Behrens, C., Petersen, K. H., Egholm, M., Nielsen, J., Buchardt O., and Dahl, O. (1995) A new achiral reagent for the incorporation of multiple amino groups into oligonucleotides. Bioorg. Med. Chem Lett. 5, 1785-1790.
10. Will, D. W., Pritchard, C. E., and Brown, T. (1991) The synthesis of oligonucleotides that contain 2,4-dinitrophenyl reporter groups. Carbohydr Res. 216, 315-322.
11. Kuusela, S., Azhayev, A., Guzaev, A., and Lonnberg, H. (1995) The effect of 3′-terminal monophosphate group on metal-ion-promoted hydrolysis of phosphodiester bonds of short oligonucleoutides. J. Chem. Soc., Perkin Trans. 2, 1197-1202.