Effects of intravenous nonsteroidal antiinflammatory drugs on a C-fiber reflex elicited by a wide range of stimulus intensities in the rat

Journal of Pharmacology and Experimental Therapeutics

Volumn 276, Issue 3, 1996, Pages 1232-1243

  Bustamante, Diego ^b   Paeile, Carlos ^b   Willer, Jean Claude ^c   Le Bars, Daniel ^a  

^a INSERM   (France)

^b UNIVERSITY OF CHILE   (Chile)

^c PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTIINFLAMMATORY AGENT; INDOMETACIN;

ANIMAL; ARTICLE; DOSE RESPONSE; DRUG EFFECT; ELECTROSTIMULATION; INTRAVENOUS DRUG ADMINISTRATION; NERVE FIBER; RAT; REFLEX; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ASPIRIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; INDOMETHACIN; INJECTIONS, INTRAVENOUS; NERVE FIBERS; RATS; RATS, SPRAGUE-DAWLEY; REFLEX;

EID: 0030111316     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (95)

1. ANG, E. T., GOLDFARB, G. AND BOCCARD, E.: Analgesic efficacy of proparacetamol hydrochlorate 2 g versus pentazocine 30 mg after orthopedic surgery. Eur. J. Pain 11: 137-142, 1990.
2. ANTOGNINI, J. F. Intrathecal acetylsalicylate acid and indomethaci n are not analgesic for a supramaximal stimulus. Anesth. Analg. 76: 1079-1082, 1993
3. ATTAL, N., KAYSER, V., ESCHALIER, A., BENOIST, J. M AND GUILBAUD, G : Behavioural and electrophysiological evidence for an analgesic effect of a nonsteroidal anti-inflammatory agent, sodium diclofenac. Pain 35: 341-348, 1988.
4. BANNWARTH, B., NETTER, P., POUREL, J., ROYER, R. J. AND GAUCHER, A.: Clinical pharmacokinetics of nonsteroidal antiinflammatory drugs in the cerebrospinal fluid. Biomed. Pharmacother. 43: 121-126, 1989.
5. BANNWARTH, B., NETTER, P., LAPICQUE, F., PÉRÉ, P., THOMAS, P. AND GAUCHER, A : Indomethacin plasma and cerebrospinal fluid concentrations in humans. Relationship with the analgesic activity. Eur. J. Clin. Pharmacol. 38: 343-348, 1990.
6. BANNWARTH, B., NETTER, P., LAPICQUE, F., GILLET, P., PÉRÉ, P., BOCCARD, E., ROYER, R. J. AND GAUCHER, A.: Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol. Br. J. Clin. Pharmacol. 34: 79-81, 1992.
7. BANNWARTH, B , DEMOTES-MAINARD, F., SCHAEVERBEKE, T., LABAT, L. AND DEHAIS, J.: Central analgesic effects of aspirin-like drugs Fundam. Clin. Pharmacol. 9: 1-7, 1995.
8. BJORKMAN, R., HEDNER, J., HEDNER, T. AND HENNING, M., Central, naloxonereversible antinociception by diclofenac in the rat. Arch. Pharmacol. 342: 171-176, 1990.
9. BOLTON, S.: Pharmaceutical Statistics, 2nd ed., Marcel Dekker, New York, 1990.
10. BROMM, B., RUNDSHAGEN, I. AND SCHAREIN, E.: Central analgesic effects of acetylsalicylic acid in healthy men. Arzneim. Forsch Drug. Res. 41: 1123-1129, 1991.
11. BRUNE, K.: Spinal cord effects of antipyretic analgesics. Drugs 47: (Suppl. 5): 21-27, 1994.
12. BRUNE, K., BECK, W. S., GEISSLINGER, G., MENZEL-SOGLOWEK, S., PESKAR, B. M. AND PESKAR, B. A.: Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition. Experientia 47: 257-261, 1991.
13. BRUNE, K., MENZEL-SOGLOWEK S. AND ZEILHOFER H. H.: Differential analgesic effects of aspirin-like drugs. Drugs 44: (Suppl. 5), 52-59, 1992.
14. BUSTAMANTE, D., MIRANDA, H., PELISSIER, T. AND PAEILE, C.: Analgesic action of clonixin, nifedipine and morphine using the formalin test. Gen. Pharmacol. 20: 319-322, 1989.
15. BUTLER, S. H. AND WEIL-FUGAZZA, J : The foot-bend procedure as test of nociception for chronic studies in a model of monoarthritis in the rat. Pharmacol. Comm. 4: 327-334, 1994.
16. CARLSON, R. P., DATKO, L. J., WELCH, T. M., PURVIS, W. F., SHAW, G. W., THOMPSON, J. L. AND BRUNNER, T. R.: An automated microcomputer based system for determing canine paw pressure quantitatively in the dog synovites model. J. Pharmacol. Methods 15: 95-104, 1986a.
17. CARLSSON, K-H., MONZEL, W. AND JURNA, I.: Depression by morphine and the non-opioid analgesic agents, metamizol (dipyrone), lysine acetylsalicylate and paracetamol of activity in rat thalamus neurones evoked by electrical stimulation of nociceptive afferents. Pain 32: 313-326, 1988.
18. CHAU, T. T.: Analgesic testing in animal models In Pharmacological Methods in the Control of Inflammation, ed. by J. Y. Chang and A. J. Lewis pp. 195-212, Alan R. Riss, New York, 1989.
19. CHEN, A. C. N AND CHAPMAN, C. R.: Aspirin analgesia evaluated by event-related potentials in man: Possible central action in brain. Exp. Brain Res. 39; 359-364, 1980.
20. COFFMAN, J. D : The effects of aspirin on pain and hand blood flow responses to intra-arterial injection of bradykinm in man. Clin. Pharmacol Ther 7: 26-37, 1966.
21. DE JALON, P. D. G., HARRISON, F. J J., JOHNSON, K. I., KOZMA, C. AND SCHNELLE, K., A modified cold stimulation technique for the evaluation of analgesic activity in human volunteers. Pain 22: 183-189, 1985.
22. DELEO, J., COLBURN, R. W., COOMBS, D. W. AND ELLIS, M : The differentiation of NSAIDs and prostaglandins action using a mechanical visceral pain model in the rat. Pharmacol. Biochem. Behav. 33: 253-255, 1989.
23. DEVOGHEL, J. C.: Small intrathecal doses of Iysine-acetylsalicylate relieve intractable pain in man. J Int. Med. Res. 11: 90-91, 1983.
24. DOMER, F : Characterization of the analgesic activity of ketorolac in mice. Eur. J. Pharmacol 177: 127-135, 1990.
25. DUBINSKY, B., GEBRE-MARIAM, S., CAPETOLA, R. J. AND ROSENTHALE, M. E.: The antialgesic drugs: human therapeutic correlates of their potency in laboratory animal models of hyperalgesia. Agents Action 20: 50-60, 1987.
26. FABBRI, A., CRUCCU, G., SPERTI, P., RIDOLFI, M , CIAMPANI, T , LEARDI, M G., FERRACUTI, S. AND BONIFACIO, V.: Piroxicam-induced analgesia: evidence for a central component which is not opioid mediated. Experientia 48: 1139-1142, 1992
27. FALINOWER, S., WILLER, J.-C., JUNIEN, J.-L AND LE BARS, D.: A C-fibre reflex modulated by heterotopic noxious somatic stimuli in the rat. J. Neurophysiol. 72: 194-213, 1994.
28. FARKAS, J. C., LARROUTUROU, P , MORIN, J. P., LAURIAN, C., HUCHET, J., CORMIER, J. M AND BOCCARD, E.: Analgesic efficacy of an injectable acetomiphen versus a dipyrone plus pitofenone plus fenpivenmum association after abdominal aortic repair Cur Ther Res. 51: 19-27, 1992.
29. FERREIRA, S. H., NAKAMURA, M. AND DEABREU CASTRO, M. S.: The hyperalgesic effects of prostacyclin and prostaglandin E2. Prostaglandins 16: 31-37, 1978a
30. FERREIRA, S., BERENICE, H , LORENZETTI, B. AND CORREA, F. M. A.: Central and peripheral anti-algesic action of aspirin-like drugs Eur. J. Pharmacol. 53: 30-48, 1978b.
31. FOSTER, C., ANTON, F., REEH, P W., WEBER, E. AND HANDWERKER, H. O.- Measurement of the analgesic effects of aspirin with a new experimental algesimetric procedure. Pain 32: 215-222, 1988.
32. FOSTER, C., MAGERL, W., BECK, A., GEISSLINGER, G., GALL, T., BRUNE, K. AND HANDWERKER, H. O.: Differential effects of dipyrone, ibuprofen and paracetamol on experimentally induced pain in man. Agents Actions 35: 112-121, 1992.
33. GELGOR, L., BUTKOW, N. AND MITCHELL, O.: Effects of systemic non-steroidal anti-inflammatory drugs on nociception during tail ischaemia and on reperfusion hyperalgesia in rats. Br. J. Pharmacol, 105: 412-416, 1992.
34. GRANADOS-SOTO, V., FLORES-MURRIETA, F. J., LOPEZ-MUNOZ, F. J., SALAZAR, L. A., VILLARREAL, J. E. AND CASTANEDA-HERNANDEZ, G : Relationship between paracetamol plasma levels and its analgesic effects in the rat. J. Pharm. Pharmacol. 44: 741-744. 1992.
35. GROPPETTI, A., BRAGA, P. C., BIELLA, G., PARENTI, M., RUSCONI, L. AND MANTEGAZZA, P.: Effect of aspirin on serotonin and met-enkephalin in brain, correlation with the antinociceptive activity of the drug. Neuropharmacology 27: 499-505, 1988
36. GUIEU, R., BLIN, O., POUGET, J. AND SERRATEICE, G.: Analgesic effects of indomethacin shown using the nociceptive flexion reflex in humans. Ann. Rheumat Dis. 51: 391-393, 1992.
37. GUILBAUD, G., BENOIST, J. M., GAUTRON, M. AND KAYSER, V.: Aspirin clearly depresses responses of ventrobasal thalamus neurons to joint stimuli in arthritic rats. Pain 13: 153-163, 1982.
38. GUIRIMAND, F., STRIMBU-GOZARIU, M., WILLER, J.-C. AND LE BARS, D.: Effects of mu, delta and kappa opioid antagonists on the depression of a C-fiber reflex by intrathecal morphine and DAGO in the rat. J. Pharmacol. Exp. Ther. 269: 1007-1020, 1994.
39. GUIRIMAND, F., CHAUVIN, M., WILLER, J.-C. AND LE BARS D.: Effects of intravenous morphine and buprenorphine on a C-fiber reflex in the rat. J. Pharmacol. Exp. Ther., 273: 830-841, 1995.
40. GUZMAN, F., BRAUN, C., LIM, R. K. S., POTTER, G. D. AND RODGERS, D W.: Narcotic and non-narcotic analgesics which block visceral pain evoked by intraarterial injection of bradykinin and other algesic agents. Arch. Int. Phamacodyn. Ther. 149: 571-588, 1964.
41. GYIRES, K. AND TORMA, Z.: The use of the writhing test in mice for screening different types of analgesics. Arch. Int. Pharmacodyn. 267: 131-140, 1984.
42. HENDERSHOT, L. C. AND FORSAITH, J.: Antagonism of the frequency of phenylqui-none-induced writhing in the mouse by weak analgesics and nonanalgesics J. Pharmacol. Exp Ther. 125: 237-240, 1959.
43. HUNSKAAR, S.: Similar effects of acetylsalicylic acid and morphine on immediate responses to acute noxious stimulation. Pharmacol. Toxicol 60: 167-170, 1987.
44. HUNSKAAR, S. AND HOLE, K.: The formalin test in mice: Dissociation between inflammatory and non-inflammatory pain. Pain 30: 103-114, 1987.
45. HUNSKAAR, S , FASMER, O. B. AND HOLE, K.: Formalin test in mice, a useful technique for evaluating mild analgesics. J. Neurosci. Methods 14: 69-76, 1985.
46. HUNSKAAR, S., BERGE, O-G. AND HOLE, K.: Dissociation between antinociceptive and antiinflammatory effects of acetylsalicylic acid and indomethacin in the formalin test. Pain 25: 125-132, 1986.
47. JONES, S. F., MCQUAY, H. J., MOORE, R. A. AND HAND, C. W.: Morphine and ibuprofen compared using the cold pressor test. Pain 34: 117-122, 1988.
48. JURNA, I. AND BRUNE, K.: Central effect of the non-steroid anti-inflammatory agents, indometacin, ibuprofen, and diclofenac, determined in C fibreevoked activity in single neurones of the rat thalamus. Pain 41: 71-80, 1990.
49. JURNA, I., SPOHRER, B. AND BOCK, R.: Inthathecal injection of acetylsalicylic acid, salicylic acid and indometacin depresses C fibre-evoked activity in the rat thalamus and spinal cord. Pain 49: 249-256, 1992.
50. KEITH, E. F.: Evaluation of analgesic substances. Am. J. Pharm. 132: 202-230, 1960
51. KENAKIN, T.: The classification of drugs and drug receptors in isolated tissues Pharmacol. Rev. 36: 165-222, 1984.
52. KENAKIN, T.: Pharmacological Analysis of Drug-Receptor Interaction, 2nd ed., Raven Press, New York, 1993.
53. KUZUNA, S. AND KAWAI, K.: Evaluation of analgesic agents in rats vith adjuvant arthritis. Chem. Pharm. Bull 23: 1184-1191, 1975
54. LEVITAN, H. AND BARKER, J.: Effects of non-narcotic analgesics on membrane permeability of molluscan neurones. Nature 239: 55-57, 1972.
55. LIM, R. K. S. AND GUZMAN, F.: Manifestation of pain in analgesic evaluation in animal and man. In Pain: Proceedings of the International Symposium on Pain, ed. by A. Soulairac. J Cahn and J. Charpentier, pp. 119-152, Academic Press. New York, 1968.
56. LIM, R. K S., GUZMAN, F., RODGERS, D. W., GOTO, K., BRAUN, C., DICKERSON, C. D. AND ENGLE, R. J. V: Site of action of narcotic and nonnarcotic analgesics determined by blocking bradykinin-evoked visceral pain. Arch. Int. Pharmacodyn. 152: 25-58, 1964.
57. LIM, R. K S , MILLER, D. G., GUZMAN, F., RODGERS, D. W., RODGERS, R. W., WANG, S. K., CHAO, P. Y AND SHIH, T. Y. Pain and analgesia evaluated by the intraperitoneal bradykinin-evoked pain method in man. Clin. Pharmacol. Ther. 8: 521-542, 1967.
58. LUTTINGER, D.: Determination of antinociceptive efficacy of drugs in mice using different water temperatures in a tail-immersion test. J. Pharmacol Methods 13: 351-357, 1985.
59. MALMBERG, A B. AND YAKSH, T L.: Antinociceptive actions of spinal antiinflammatory agents on the formalin test in the rat. J. Pharmacol. Exp. Ther. 263: 136-146, 1992.
60. MCCORMACK, K. J.: Non-steroidal anti-inflammatory drugs and spinal nociceptive processing. Pain 59: 9-43, 1994.
61. MCCORMACK, K AND BRUNE, K.: Dissociation between the antinociceptive and anti-inflammatory effects of the nonsteroidal anti-inflammatory drugs. A survey of their analgesic efficacy. Drugs 41: 533-547, 1991.
62. NETTER, P., KAPICQUE, F., BANNWARTH, B , TAMISIER, J. N., HOMAS, P. AND ROYER, R. J., Diffusion of intramuscular ketoprofen into the cerebrospinal fluid Eur. J Clin. Pharmacol. 29: 319-321, 1985.
63. NIELSEN, J. C., BJERRING, P., ARENDT-NIELSEN, L. AND PETTERSON, K J.: Analgesic efficacy of immediate and sustained released paracetamol and plasma concentration of paracetamol. Double blind, placebo-controlled evaluation using painful laser stimulation. Eur. J. Clin. Pharmacol. 42: 261-264, 1992.
64. OCHS, H. R., GREENLATT, D. J., ABERNETHY, D. R., ARENDT, R. M., GRELOFF, J., EICHELKRAUT, W. AND HAN, N. Cerebrospinal fluid uptake and peripheral distribution of centrally acting drugs: Relation to lipid solubility. J. Pharm. Pharmacol. 37: 428-131, 1985.
65. OKUYAMA, S. AND AIHARA, H.: Effects of morphine and indomethacin on evoked neuronal responses of ventrobasal thalamic neurone: site of action of analgesic drugs in adjuvant arthritic rats. Japan. J. Pharmacol 36: 177-186, 1984.
66. PELISSIER, T , ALLOUI, A., CAUSSADE, F., CLOAREC, A., LAVARENNE, J. AND ESCHALIER, A.: Evidence for a spinal tropisetron-inhibited antinociceptive effect of paracetamol. Fundam. Clin. Pharmacol. 8: 263, 1994.
67. PELLERIN, M., HARDY, F., ABERGEL, A., BOULE, D., PALACCI, J. H , BABINET, P., WINGTIN, L. N. G., GLOWINSKI, J., AMIOT, J.-F., MECHALI, D., COLBERT, N. AND STARKMAN, M.: Douleur chronique rebelle des cancereux: Intérêt de l'injection intrarachidienne d'acétylsalycilate de lysine. Soixante observations. Presse Méd. 16: 1465-1468, 1987.
68. PILETTA, P., PORCHET, H. C. AND DAYER, P.: Central analgesic effect of acetaminophen but not of aspirin Clin. Pharmacol. Ther. 49: 350-354, 1991.
69. 50, values in mice. Arch. Int. Pharmacodyn. 273: 212-220, 1985.
70. RANDALL, L. O. AND SELLITO, J. J.: A method for measurement of analgesic activity on inflamed tissue Arch. Int. Pharmacodyn. Ther. 111: 409-419, 1957.
71. RICCIOPPO-NETO, F. AND NARAHASHI, T.: Ionic mechanism of the sahcylate block of nerve conduction. J. Pharmacol. Exp. Ther. 199: 454-463, 1976.
72. RICCIOPPO-NETO, F.: Further studies on the actions of salicylates on nerve membranes. Eur. J. Pharmacol. 68: 155-162, 1980.
73. ROMER, D.: Pharmacological evaluation of mild analgesics Br. J Clin. Pharmacol. 10: 247-251, 1980.
74. SANDRINI, G., RUIZ, L., CARAPARO, M., GARAGOLI, F., BERETTA, A. AND NAPPI, G.: Central analgesic activity of ibuprofen. A neurophysiological study in humans. Int. J. Clin. Pharm. Res. 12: 197-204, 1992.
75. SCHADY, W. AND TOREBJORK, H. E.: Central effects of zomepirac on pain evoked by intraneural stimulation in man J Clin. Pharmacol. 24: 429-435, 1984.
76. SHIBATA, M.: Pharmacological study of formalin-induced inflammatory pain response. Jap. J. Oral Biol. 27: 890-901, 1985.
77. SIEGMUND, E. A., CADMUS, R. A. AND Lu, G.: A method for evaluating both non-narcotic and narcotic analgesics. Proc. Soc. Exp. Biol. Med. 95: 729-731, 1957a.
78. SIEGMUND, E. A., CADMUS, R. A. AND LU, G.: Screening analgesics, including aspirin-type compound, based upon the antagonism of chemically induced "writhing" in mice. J. Pharmacol. Exp. Ther. 119: 184-193, 1957b.
79. STEINFELS, G F. AND COOK, L.: Antinociceptive profiles of mice and kappa opioid agonists in a rat tooth pulp stimulation procedure. J. Pharmacol. Exp. Ther. 236: 111-117, 1985.
80. STRIMBU-GOZARIU, M., GUIRIMAND, F., WILLER, J.-C. AND LE BARS, D.: A sensitive test for studying the effects of opioids on a C-fibre reflex elicited by a wide range of stimulus intensities in the rat. Eur J. Pharmacol. 237: 197-205, 1993.
81. TAIWO, Y. AND LEVINE, J.: Prostaglandins inhibits endogenous pain control mechanisms by blocking transmission at spinal noradrenergic synapses. J. Neurosci. 8: 1346-1349, 1988.
82. TATSUO, M A. K. F., CARVALHO, W. M., SILVA, C. V., MIRANDA, A. E. G., FERREIRA, S. H AND FRANCISCHI, J. N.: Analgesic and antiinflammatory effects of dipyrone in rat adjuvant arthritis model. Inflammation 18: 399-409, 1994.
83. TELEKES, A., HOLLAND, R. L. AND PECK, A. W.: Indomethacin: Effects on cold-induced pain and the nervous system in healthy volunteers Pain 30: 321-328, 1987.
84. TJÖLSEN, A , LUND, A. AND HOLE, K.: Antinociceptive effect of paracetamol in rats is partly dependent on spinal serotonergic system. Eur. J. Pharmacol 193: 193-201, 1991
85. TONUSSI, C. R. AND FERREIRA, S. H.: Mechanism of diclofenac analgesia: direct blockade of inflammatory sensitization. Eur. J. Pharmacol. 251: 173-179, 1994.
86. UPHOUSE, L A., WELCH, S. P., WARD, C. R., ELLIS, E. F. AND EMBREY, J. P.: Antinociceptive activity of intrathecal ketorolac is blocked by the K-opioid receptor antagonist, nor-binaltorphimine. Eur. J. Pharmacol. 242: 53-58, 1993.
87. VAN ARMAN, C. G., CARISON, R. P., RISLEY, E. A., THOMAS, R. H. AND NUSS, G. W.: Inhibitory effects of indomethacin, aspirin and certain other drugs on inflammation induced in rat and dog by carrageenan, sodium urate and ellagic acid. J. Pharmacol. Exp. Ther. 175: 459- 468, 1970.
88. VANE, J. R.: Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biol 231: 232-235, 1971.
89. VESCOVI, P., PASSERI, M., GERRA, G. AND GROSSI, E.: Naloxone inhibits the early phase of diclofenac analgesia in man. The Pain Clinic 1: 151-157, 1987.
90. VINEGAR, R., TRUAX, J. F AND BELPH, J. L.: Quantitative comparison of the analgesic and anti-inflammatory activities of aspirin, fenacetin and acetaminophen in rodents. Eur. J. Pharmacol. 37: 23-30, 1976.
91. WALKER, J., ARROYO, J. F., NGUYEN, T. AND DAY, R O.: Analgesic efficacy of non-steroidal anti-inflammatory drugs in experimental pain in humans. Br. J. Clin. Pharmac 36: 417-425, 1993.
92. WILLER, J-C.: Comparative study of perceived pain and nociceptive flexion reflex in man Pain 3: 69-80, 1977.
93. WILLER, J.-C., DE BROUCKER, T., BUSSEL, B., ROBY-BRAMY, A. AND HARREWYN, J.-M., Central analgesic effects of ketoprofen in humans: Electrophysiological evidence for a supraspinal mechanism in a double-blind and cross-over study. Pain 38: 1-7, 1989.
94. WINTER, C. A. AND FLATAKER, L : Reaction thresholds to pressure in edematous hindpaws of rats and responses to analgesic drugs. J. Pharmacol. Exp. Ther. 150: 165-171, 1965.
95. WRIGHT, A. AND DAVIES, I: The recording of brain evoked potentials resulting from intra-articular focused ultrasonic stimulation: A new experimental model for investigating joint pain in humans. Neurosci. Lett. 97: 145-150, 1989.