A comparison of cleavable and noncleavable hydrazinopyridine linkers for the99mTc labeling of fab' monoclonal antibody fragments

Bioconjugate Chemistry

Volumn 7, Issue 2, 1996, Pages 255-264

  Bridger, Gary J ^a   Abrams, Michael J ^a   Padmanabhan, Sreenivasan ^a   Gaul, Forrest ^a   Larsen, Scott ^a   Henson, Geoffrey W ^a   Schwartz, David A ^a   Longley, Clifford B ^b   Burton, Charlotte A ^b   Ultee, Michiel E ^b  

^a Johnson Matthey Pharmaceutical Res   (United States)

^b Cytogen Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDES; CHELATION; ESTERS; MAMMALS; MEDICAL IMAGING; MOLAR RATIO; SULFUR COMPOUNDS; TUMORS;

AMIDE ESTERS; AMIDE GROUPS; ANTIBODY-FRAGMENT; BIFUNCTIONAL CHELATING AGENT; DISULFIDE GROUPS; ESTER GROUPS; FREE THIOL GROUP; LABELINGS; MONOESTERS; WHOLE-BODY;

MONOCLONAL ANTIBODIES;

EID: 0030111248     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc960008r     Document Type: Article

References (9)

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3. Parker, D., and Jankowski, K. J. (1993) Diagnosis and Therapy with Antibody Conjugates of Metal Radioisotopes. In Advances in Metals in Medicine (M. J. Abrams and B. A. Murrer, Eds.) pp 29-75, JAI Press Inc.
4. 99mTc-Protein Conjugates. Bioconjugate Chem. 2, 333-336.
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8. Rhodes, B. A., Buckelew, J. M., Pant, K. D., and Hinkle, G. H. (1990) Quality control test for immunoreactivity of radiolabelled antibody. Biotechniques 8, 70-73.
9. Alvarez, V. L., Lopes, A. D., Lee, C., Rodwell, J. D., and McKearn, T. J. (1988) Site-Specific Modification of 111-Indium Labeled Monoclonal Antibodies using Nude Mouse Xenograft Systems. In Covalent Modification of Monoclonal Antibodies (J. D. Rodwel, Ed.) p 283, Marcel Decker, New York.