Alterations in cell signaling and related effector functions in T lymphocytes in burn/trauma/septic injuries

Shock

Volumn 5, Issue 3, 1996, Pages 157-166

  Sayeed, Mohammed M ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; BURN; CELL COMMUNICATION; CELL DIVISION; COMPARATIVE STUDY; EDITORIAL; GENETIC TRANSCRIPTION; GENETICS; HUMAN; INJURY; PATHOLOGY; PHYSIOLOGY; REGULATORY T LYMPHOCYTE; SEPSIS; SIGNAL TRANSDUCTION;

BURNS; CELL COMMUNICATION; CELL DIVISION; HUMANS; SEPSIS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; TRANSCRIPTION, GENETIC; WOUNDS AND INJURIES;

EID: 0030100203     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-199603000-00001     Document Type: Review

References (111)

1. Altman A, Mustelin T, Coggeshall KM: T lymphocyte activation: A biological model of signal transduction. Crit Rev Immunol 10:347-391, 1990.
2. Rao A: Signaling mechanisms in T cells. Crit Rev Immunol 10:495-519, 1991.
3. Fraser JD, Straus D, Weiss A: Signal transduction events leading to T-cell lymphokine gene expression. Immunol Today 14:357-362, 1993.
4. Weiss A, Littman DR: Signal transduction by lymphocyte antigen receptors. Cell 76:263-274, 1994.
5. Howe LR, Weiss A: Multiple kinases mediate T-cell-receptor signaling. Trends Biochem Sci 20:59-64, 1995.
6. Robey E, Allison JP: T-cell activation: Integration of signals from the antigen receptor and costimulatory molecules. Immunol Today 16:306-309, 1995.
7. Miller CL, Baker CC: Changes in lymphocyte activity after thermal injury: The role of suppressor cells. J Clin Invest 63:202-210, 1979.
8. Wolfe JH, Wu AV, O'Connor NE, Saporoschetz I, Mannick JA: Anergy, immunosuppressive serum, and impaired lymphocyte blastogenesis in bum patients. Arch Surg 117:1266-1271, 1982.
9. Wood JJ, Rodrick ML, O'Mahoney JB, et al: Inadequate interleukin-2 production: A fundamental immunological deficiency in patients with major burns. Ann Surg 200:311-320, 1984.
10. Teodorczyk-Injeyan JA, Sparkes BG, Mills GB, Peters WJ, Falk RE: Impairment of T cell activation in burn patients: A possible mechanism of thermal injury-induced immunosuppression. Clin Exp Immunol 65: 570-581, 1986.
11. Faist E, Ertel W, Cohnert T, Huber P, Inthorn D, Heberer G: Immunoprotective effects of cyclooxygenase inhibition in patients with major surgical trauma. J Trauma 30:8-17, 1990.
12. Tchervenkov JI, Diano E, Meakins JL, Christou NV: Susceptibility to bacterial sepsis: Accurate measurement by the delayed-type hypersensitivity skin test score. Arch Surg 121:37-40, 1986.
13. Christou NV, Zakaluzny I, Marshall JC, Nohr CW: The effect of the immunomodulator RU 41,740 (biostim) on the specific and nonspecific immunosuppression induced by thermal injury or protein deprivation. Arch Surg 123:207-211, 1988.
14. Faist E, Schinkel C, Zimmer S, Kremer J, Von Donnersmarck GH, Schildberg F: Inadequate interleukin-2 synthesis and interleukin-2 messenger expression following thermal and mechanical trauma in humans is caused by defective transmembrane signalling. J Trauma 34:846-854, 1993.
15. Horgan AF, Mendez MV, O'Riordain DS, Holzheimer RG, Mannick JA, Rodrick ML: Altered gene transcription after burn injury results in depressed T-lymphocyte activation. Ann Surg 220:342-352, 1994.
16. Horgan AF, O'Riordain DS, Chin DHL, Mannick JA, Rodrick ML: The role of cyclic adenosine monophosphate in the suppression of cellular immunity after thermal injury. Arch Surg 129:1284-1289, 1994.
17. Ellner JJ, Spagnuolo PJ: Suppression of antigen and mitogen-induced human T lymphocyte DNA synthesis by bacterial lipopolysaccharide: Mediation by monocyte activation and production of prostaglandins. J Immunol 123:2689-2695, 1979.
18. Vallera DA, Gamble CE, Schmidtke JR: Lipopolysaccharide-induced immunomodulation of the generation cell-mediated cytotoxicity. II. Evidence for the involvement of a regulatory B lymphocyte. J Immunol 124:641-649, 1980.
19. Ayala A, Perrin MM, Chaudry IH: Defective macrophage antigen presentation following hemorrhage is associated with the loss of MHC class II (Ia) antigens. Immunology 70:33-39, 1990.
20. Chaudry IH, Ayala A, Ertel W, Stephan RN: Hemorrhage and resuscitation: Immunological aspects. Am J Physiol 259:R663-R678, 1990.
21. Gough DB, Jordan A, Mannick JA, Rodrick ML: Impaired cell-mediated immunity in experimental abdominal sepsis and the effect of interleukin 2. Arch Surg 127:859-863, 1992.
22. Watson RW, Redmond HP, Bouchier-Hayes D: Role of endotoxin in mononuclear phagocyte-mediated inflammatory responses. J Leukocyte Biol 56:95-103, 1994.
23. Chaudry IH, Ayala A: Immunological Aspects of Hemorrhage. Austin, TX: Landes, 1992, pp 1-132.
24. Casey LC, Balk RA, Bone RC: Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome. Ann Intern Med 119:771-778, 1993.
25. O'Riordain DS, Mendez MV, O'Riordain MG, et al: Molecular mechanisms of decreased interleukin-2 production after thermal injury. Surgery 114:407-415, 1993.
26. 2+ signalling and proliferative responses during sepsis. Shock 1:466-471, 1994.
27. 2-induced T-lymphocyte proliferative suppression in sepsis. Infect Immun 63:3101-3105, 1995.
28. Abbas AK, Lichtman AH, Pober JS: Cellular and Molecular Immunology. Philadelphia PA: W.B. Saunders Co., 1994.
29. Weiss A: Molecular and genetic insights into T cell antigen receptor structure and function. Annu Rev Genet 25:487-510, 1991.
30. Berridge MJ: Inositol trisphosphate and calcium signalling. Nature 361: 315-325, 1993.
31. Miceli CM, Parnes JR: Role of CD4 and CD8 in T cell activation and differentiation. Adv Immunol 53:59-122, 1993.
32. Linsley PS, Ledbetter JA: The role of the CD28 receptor during T cell responses to antigen. Annu Rev Immunol 11:191-212, 1993.
33. June CH, Fletcher MC, Ledbetter JA, Samelson LE: Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation. J Immunol 144:1591-1599, 1990.
34. Ullrich A, Schlessinger J: Signal transduction by receptors with tyrosine kinase activity. Cell 61:203-212, 1990.
35. Imbert V, Peyron J, Farahi Far D, Mari B, Auberger P, Rossi B: Induction of tyrosine phosphorylation and T-cell activation by vanadate peroxide, an inhibitor of protein tyrosine phosphatases. Biochem J 297: 163-173, 1994.
36. Chan AC, Desai DM, Weiss A: The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction. Annu Rev Immunol 12:555-592, 1994.
37. Berry N, Nishizuka Y: Protein kinase C and T cell activation. Eur J Biochem 189:205-214, 1990.
38. Kumagai N, Benedict SH, Mills GB, Gelfand EW: Requirements for the simultaneous presence of phorbol esters and calcium ionophores in the expression of human T lymphocyte proliferation-related genes. J Immunol 139:1393-1399, 1987.
39. Kumagai N, Benedict SH, Mills GB, Gelfand EW: Comparison of phorbol ester/calcium ionophore and phytohemagglutinin-induced signaling in human T lymphocytes: Demonstration of interleukin 2-independent transferrin receptor gene expression. J Immunol 140:37-43, 1988.
40. ras in T cells. Immunol Today 13: 89-92, 1992.
41. ras regulatory pathways coexist in T cells. Mol Cell Biol 12: 3305-3312, 1992.
42. Siegel JN, Klausner RD, Rapp UR, Samelson LE: T cell antigen receptor engagement stimulates c-raf phosphorylation and induces c-raf-associated kinase activity via a protein kinase C-dependent pathway. J Biol Chem 265:18472-18480, 1990.
43. Calvo V, Bierer BE, Vik TA: T cell receptor activation of a ribosomal S6 kinase activity. Eur J Immunol 22:457-462, 1992.
44. Howe LR, Leevers SJ, Gomez N, Nakielny S, Cohen P, Marshall CJ: Activation of the MAP kinase pathway by the protein kinase raf. Cell 71:335-342, 1992.
45. Chen RH, Sarnecki C, Blenis J: Nuclear localization and regulation of erk- and rsk-encoded protein kinases. Mol Cell Biol 12:915-927, 1992.
46. O'Keefe SJ, Tamura J, Kincaid RL, Tocci MJ, O'Neill EA: FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. Nature 357:692-694, 1992.
47. Clipstone NA, Crabtree GR: Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 357:695-697, 1992.
48. Crabtree GR: Contingent genetic regulatory events in T lymphocyte activation. Science 243:355-361, 1989.
49. Waldmann TA: The IL-2/IL-2 receptor system: A target for rational immune intervention. Immunol Today 14:264-270, 1993.
50. Tsudo M, Kozak RW, Goldman CK, Waldmann TA: Demonstration of a non-Tac peptide that binds interleukin 2: A potential participant in a multichain interleukin 2 receptor complex. Proc Natl Acad Sci USA 83:9694-9698, 1986.
51. Sharon M, Klausner RD, Cullen BR, Chizzonite R, Leonard WJ: Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions. Science 234:859-863, 1986.
52. Takeshita T, Asao H, Ohtani K, et al: Cloning of the gamma chain of the human IL-2 receptor. Science 257:379-382, 1992.
53. Farrar WL, Anderson WB: Interleukin-2 stimulates association of protein kinase C plasma membrane. Nature 315:233-235, 1985.
54. Mills GB, Stewart DJ, Mellors A, Gelfand EW: Interleukin 2 does not induce phosphatidylinositol hydrolysis in activated T cells. J Immunol 136:3019-3024, 1986.
55. LeGrue SJ: Does interleukin 2 stimulus-response coupling result in generation of intracellular second messengers? Lymphokine Res 7:187-200, 1988.
56. Tigges MA, Casey LS, Koshland ME: Mechanism of interleukin-2 signaling: Mediation of different outcomes by a single receptor and transduction pathway. Science 243:781-786, 1989.
57. Benedict SH, Mills GB, Gelfand EW: Interleukin 2 activates a receptor-associated protein kinase. J Immunol 139:1694-1697, 1987.
58. Rapaport FT, Converse JM, Horn L, Ballantyne DL Jr, Mulholland JH: Altered reactivity to skin homografts in severe thermal injury. Ann Surg 159:390-395, 1964.
59. Riddle PR, Barenbaum MC: Postoperative depression of the lymphocyte response to phytohemagglutinin. Lancet 1:746-748, 1967.
60. O'Mahoney JB, Palder SB, Wood JJ, et al: Depression of cellular immunity after multiple trauma in the absence of sepsis. J Trauma 24:869-875, 1984.
61. Daniels JC, Sakai H, Cobb EK, Lewis SR, Larson DL, Ritzmann SE: Evaluation of lymphocyte reactivity studies in patients with thermal burns. J Trauma 11:595-601, 1971.
62. Rodrick ML, Wood JJ, O'Mahoney JB, et al: Mechanisms of immunosuppression associated with severe nonthermal traumatic injuries in man: Production of interleukin 1 and 2. J Clin Immunol 6:310-318, 1986.
63. Faist E, Kupper TS, Baker CC, Chaudry IH, Dwyer J, Baue AE: Depression of cellular immunity after major injury: Its association with posttraumatic complications and its reversal with immunomodulation. Arch Surg 121:1000-1005, 1986.
64. Hoyt DB, Ozkan AN: Immunosuppression in trauma patients. J Intensive Care 6:71-90, 1991.
65. Akiyoshi T, Koba F, Arinaga S, Miyazaki S, Wada T, Tsuji H: Impaired production of interleukin-2 after surgery. Clin Exp Immunol 59:45-49, 1985.
66. Faist E, Ertel W, Mewes A, Alkan S, Walz A, Strasser T: Trauma-induced alterations of the lymphokine cascade. In Faist E, Ninnemann J, Green D (eds): Immune Consequences of Trauma, Shock and Sepsis. Berlin: Springer-Verlag, 1989, pp 79-94.
67. Wood JJ, Grbic JT, Rodrick ML, Jordan A, Mannick JA: Suppression of interleukin 2 production in an animal model of thermal injury is related to prostaglandin synthesis. Arch Surg 122:179-184, 1987.
68. O'Riordain DS, Mendez MV, Holzheimer RG, Collins K, Mannick JA, Rodrick ML: Interleukin-2 receptor expression and function following thermal injury. Arch Surg 130:165-170, 1995.
69. Teodorczyk-Injeyan JA, McRitchie DI, Peters WJ, Lalani S, Girotti MJ: Expression and secretion of IL-2 receptor in trauma patients. Ann Surg 212:202-208, 1990.
70. Schluter B, Wolfgang K, Koller M, Erbs G, Muller FE: Differential regulation of T- and B-lymphocyte activation in severely burned patients. J Trauma 31:239-246, 1991.
71. Manger B, Weiss A, Weyand C, Goronzy J, Stobo JD: T cell activation: Differences in the signals required for IL-2 production by nonactivated T-cells. J Immunol 135:3669-3673, 1985.
72. Leonard WJ, Kronke M, Peffer NJ, Depper JM, Greene WC: Interleukin-2 receptor gene expression in normal T lymphocytes. Proc Natl Acad Sci USA 82:6281-6285, 1985.
73. Munster AM, Winchurch RA, Thupari JN, Ernst CB: Reversal of post-burn immunosuppression with low-dose polymyxin B. J Trauma 26:995-998, 1986.
74. Maejima K, Deitch E, Berg R: Promotion by burn stress of the translocation of bacteria from the gastrointestinal tracts of mice. Arch Surg 119:166-172, 1984.
75. Walker RI: The contribution of intestinal endotoxin to mortality in hosts with compromised resistance: A review. Exp Hematol 6:172-184, 1978.
76. Rodrick ML, Moss NM, Grbic JT, et al: Effects of in vivo endotoxin infusions on in vitro cellular immune responses in humans. J Clin Immunol 12:440-450, 1992.
77. Chantry D, Turner M, Abney E, Feldmann M: Modulation of cytokine production by transforming growth factor-beta. J Immunol 142:4295-4300, 1989.
78. 2) in traumatized individuals. In Faist E, Meakins J, and Schildberg FW (eds): Host Defense Dysfunction in Trauma, Shock and Sepsis; Mechanisms and Therapeutic Approaches. New York: Springer-Verlag, 1993, pp 637-650.
79. Berczi I: Neuroendocrine defense in endotoxin shock (a review). Acta Microbiol Hung 40:265-302, 1993.
80. Marshall JC: Immunologic dyshomeostasis in multiple organ failure: The gut-liver axis. In Faist E, Meakins J, Schildberg FW (eds): Host Defense Dysfunction in Trauma, Shock and Sepsis; Mechanisms and Therapeutic Approaches. New York: Springer-Verlag, 1993, pp 243-252.
81. Abraham E: Host defense abnormalities after hemorrhage, trauma, and burns. Crit Care Med 17:934-939, 1989.
82. Mosmann TR, Coffman RL: TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7:145-173, 1989.
83. Mosmann TR: Regulation of immune responses by T cells with different cytokine secretion phenotypes: Role of a new cytokine, cytokine synthesis inhibitory factor (IL10). Int Arch Allergy Appl Immunol 94:110-115, 1991.
84. Spits H, de Waal Malefyt R: Functional characterization of human IL-10. Int Arch Allergy Appl Immunol 99:8-15, 1992.
85. Powrie F, Coffman RL: Inhibition of cell-mediated immunity by IL4 and IL10. Res Immunol 144:639-643, 1993.
86. + T cells in vivo: Differential expression of IL-2 and IL-4 mRNA in recipients of cardiac allografts. J Immunol 148:1308-1314, 1992.
87. Noble A, Staynov DZ, Kemeny DM: Generation of rat Th2-like cells in vitro is interleukin-4-dependent and inhibited by interferon-γ. Immunology 79:562-567, 1993.
88. Abraham E, Freitas AA: Hemorrhage produces abnormalities in lymphocyte function and lymphokine generation. J Immunol 142:899-906, 1989.
89. 2 in immune suppression following injury. Ann Surg 214:253-263, 1991.
90. 2 in immunosuppression following thermal injury. J Trauma 24:201-207, 1984.
91. 2 depresses antigen-presenting cell function of peritoneal macrophages. J Surg Res 44:733-739, 1988.
92. 2 inhibitory effect by the tumor promoter 12.0 tetradecanoyl phorbol-13 acetate. J Clin Invest 80:333-340, 1987.
93. Goodwin JS, Bankhurst AD, Messner RP: Suppression of human T cell mitogenesis by prostaglandin: Existence of a prostaglandin-producing suppressor cell. J Exp Med 146:1719-1732, 1977.
94. 2 induction of suppressor T lymphocytes. J Immunol 132:1851-1857, 1984.
95. Faist E, Markewitz A, Fuchs D, et al: Immunomodulatory therapy with thymopentin and indomethacin: Successful restoration of interleukin-2 synthesis in patients undergoing major surgery. Ann Surg 214:264-275, 1991.
96. Horgan PG, Mannick JA, Dubravec DB, Rodrick ML: Effect of low dose recombinant interleukin 2 plus indomethacin on mortality after sepsis in a murine burn model. Br J Surg 77:401-404, 1990.
97. Butcher RW, Baird CE: Effect of prostaglandins on adenosine 3′5′-monophosphate levels in fat and other tissues. J Biol Chem 243:1713-1717, 1968.
98. Chouaib S, Fradelizi D: The mechanism of inhibition of human IL2 production. J Immunol 129:2463-2468, 1982.
99. 2 and other cyclic AMP elevating agents inhibit interleukin 2 gene transcription by counteracting calcineurin-dependent pathways. J Exp Med 178:1813-1817, 1993.
100. Meldrum DR, Ayala A, Chaudry IH: Mechanism of diltiazem's immunomodulatory effects after hemorrhage and resuscitation. Am J Physiol 265:C412-C421, 1993.
101. Hoyt DB, Junger WG, Loomis WH, Liu FC: Effects of trauma on immune cell function: Impairment of intracellular calcium signaling. Shock 2:23-28, 1994.
102. Tsien RY: Fluorescent indicators of ion concentrations. Methods Cell Biol 30:127-156, 1989.
103. 2+ in individual small cells using fluorescence microscopy with dual excitation wavelengths. Cell Calcium 6:145-157, 1985.
104. Hoyt DB, Ozkan AN, Ninnemann JL, Hansbrough JF, Pinney E, Wormsley S: Trauma peptide induction of lymphocyte changes predictive of sepsis. J Surg Res 45:342-348, 1988.
105. Ozkan AN, Hoyt DB, Tompkins S, Ninnemann JL, Sullivan JJ: Immunosuppressive effects of a trauma-induced suppressor active peptide. J Trauma 28:589-592, 1988.
106. 2 down regulation of T-cell proliferation and IL-2 production in sepsis results from cell signaling alteration. Shock 3:18, 1995 (abstract).
107. 2+ flux and catabolic response during sepsis. Am J Physiol 265:R487-R493, 1993.
108. 2+-related hepatocellular alterations during intra-abdominal sepsis. Am J Physiol 263:R553-R558, 1992.
109. Cantrell DA, Collins MK, Crumpton MJ: Autocrine regulation of T-lymphocyte proliferation: Differential induction of IL-2 and IL-2 receptor. Immunology 65:343-349, 1988.
110. Scheinman RI, Cogswell PC, Lofquist AK, Baldwin AS Jr: Role of transcriptional activation of IκBalpha; in mediation of immunosuppression by glucocorticoids. Science 270:283-286.
111. Auphan N, DiDonato JA, Rosette C, Helmberg A, Karin M: Immunosuppression by glucocorticoids: Inhibition of NF-κB synthesis. Science 270:286-290.