Comparison of two therapeutic strategies with prednisone and interferon in chronic B hepatitis;Comparación de dos esquemas de tratamiento con prednisona Interferón en la hepatitis crónica por virus B

Revista Espanola de Enfermedades Digestivas

Volumn 88, Issue 3, 1996, Pages 185-190

  Gomez Camacho F ^a,b   Poyato Gonzalez A ^a   Vignote Alguacil, M L ^a   De La Mata Garcia M ^a   Gonzalez Fernandez R A ^a   Lopez Rubio F ^a   Marchal Molina, T ^a   Mino Fugarolas G ^a  

^a Hospital Universitario Reina Soffa   (Argentina)

^b Hospital Provincial 2a Planta

Author keywords

Chronic B hepatitis; Interferon; Prednisone; Treatment

Indexed keywords

ALPHA2A INTERFERON; ANTIINFLAMMATORY AGENT; ANTIVIRUS AGENT; PREDNISONE;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; ARTICLE; CHILD; CHRONIC DISEASE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG COMBINATION; FOLLOW UP; HEPATITIS B; HUMAN; MALE; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; TIME; CHRONIC HEPATITIS; CLINICAL ARTICLE; DRUG EFFICACY; FEMALE; HISTOLOGY; VIRUS HEPATITIS;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; ANTI-INFLAMMATORY AGENTS; ANTIVIRAL AGENTS; CHILD; CHRONIC DISEASE; DRUG THERAPY, COMBINATION; FOLLOW-UP STUDIES; HEPATITIS B; HUMANS; INTERFERON ALFA-2A; MALE; MIDDLE AGED; PREDNISONE; TIME FACTORS;

EID: 0030097726     PISSN: 11300108     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Alexander GJM y Williams R. Natural history and therapy of chronic hepatitis B virus infection. Am J Med 1988; 85 (supl. l, 2A): 143-146.
2. Maynard JE, Kane MA, Alter MJ et al. Control of hepatitis B by inmunization: Global perspective. En: Enckerman AJ, ed. Viral hepatitis and liver diseases. New York, Alan R Liss, 1988; 967-969.
3. Okuda K. Primary liver cancer. Quadrennial review lecture. Dig Dis Sci 1986; 31: 133-146.
4. Popper H. Shafritz DA y Hoofnagle JH. Relation of the hepatitis B virus carrier state to hepatocellular carcinoma. Hepatlogy 1987; 7: 764-772.
5. Hoofnagle JH, Davis GL, Pappas SC et al. A short course of prednisolone in chronic type B hepatitis. Report of a randomized double-blind placebo controlled trial. Ann Intern Med 1986; 104: 12-17.
6. A Trial Group of the European Association for the Study of the Liver. Steroids in chronic B hepatitis. A randomized double-blind, multinational trial on the effect of low-dose, long-term treatment on survival. Liver 1986; 6: 227-232.
7. Hoofnagle JH, Hanson RG, Minuk GY et al. Randomized controlled trial of adenine arabinoside monophosphate for chronic type B hepatitis. Gastroenterology 1984; 86: 150-157.
8. Weller IVD, Lok ASF, Mindel A et al. Randomized controlled trial of adenine arabinoside 5-monophosphate (ARA-AMP) in chronic hepatitis B virus infectionts. Gut 1985; 26: 745-751.
9. Thomas HC, Lever AM, Scully MI et al. Approaches to the treatment of hepatitis B virus and delta-related liver disease. Semin Liver Dis 1986; 6: 34-41.
10. Davis GL y Hoofnagle JH. Interferon in viral hepatitis: role in pathogenesis and treatment. Hepatology 1986; 6: 1038-1041.
11. Hoofnagle JH, Peters M, Mullen KD et al. Randomized controlled trial of recombinant human alpha-interferon in patients with chronic hepatitis B. Gastroenterology 1988; 95: 1318-1325.
12. Fattovich G, Brollo L, Boscaro S et al. Long-term effect of low dose recombinant Interferon therapy in patients with chronic hepatitis B. J. Hepatol 1989; 9: 331-337.
13. Perrillo RP. Treatment of chronic hepatitis B with interferon: experience in Western countries. Semin Liver Dis 1989; 9: 240-248.
14. Schalm SW, De Man RA, Thomas HC et al. Chronic hepatitis B: therapeutic controversies and randomized controiled trials. Gastraenterology Internat 1989; 2: 16-24.
15. Hoofnagle JH. Alpha-Interferon therapy of chronic hepatitis B. Current status and recommendations. J Hepatol 1990; 11: S100-S107.
16. Perrillo RP, Regenstein FG, Peters MG et al. Prednisone withdrawal followed by recoinbinant alpha interferon in the treatment of chronic type B hepatitis. A randomized, controlled trial. Ann Intern Med 1988; 109: 95-100.
17. Perrillo RP, Schiff ER, Davis GR et al and The Hepatitis Interventional Therapy Group. A randomized controlled trial of interferon alpha-2b alone and after prednisone withdrawal for thetreatment of chronic hepatitis B. N Engl J Med 1990; 323: 295-301.
18. Causse X, Godinot H, Zoulim F et al. Remarkable improvement of chronic hepatitis B following simultaneous administration of interferon and short term prednisone therapy. J Hepatol 1990: suppl 2: 165.
19. Zarski JP, Causse X, Cohard M et al and French Multicenter Group. A randomized controlled trial of interferon alpha-2b alone and with simultaneous prednisone for the treatment of chronic hepatitis B. J Hepatol 1994; 20: 735-741.
20. Scheuer PJ. Classification of chronic viral hepatitis: a need for reassessment. J Hepatol 1991; 13: 372-374.
21. Fattovich G, Rugge M, Brollo L et al. Clinical, virologic and histologic outcome following seroconversion from HBeAg to anti-HBe in chronic hepatitis type B. Hepatology 1986; 6: 167-172.
22. Hoofnagle JH, Dusheiko GM. Seeff LB et al. Seroconversion from hepatitis B e antigen to antibody in chronic type B hepatitis. Ann Intern Med 1981; 94: 744-748.
23. Liaw YF, Chu CM, Su IJ et al. Clinical and histological events preceding hepatitis B e antigen seroconversion in chronic type B hepatitis. Gastroenterology 1983; 84: 216-219.
24. Viola LA, Barrison IG, Coleman JC et al. Natural history of liver disease in chronic hepatitis B surface antigen carriers. Lancet 1981; 2: 1156-1159.
25. Perrillo Rp. Antiviral therapy of chronic hepatitis B: past, present, and future. J. Hepatol 1993; 17 (suppl. 3): S56-S63.
26. Davis GL. Interferon treatment of viral hepatitis in immunocrompomissed patients. Semin Liver Dis 1989; 9: 267-272.
27. Korenman J, Baker B, Waggoner J et al. Long-term remission of chronic hepatitis B after alpha-interferon therapy. Ann Intern Med 1991; 114: 629-634.
28. Perrillo RP y Mason AL. Long-term follow-up of interferon responders in chronic hepatitis B. Progress in Hepatology (John Libbey Eurotext), 1993, pp: 47-53.
29. Perrillo RP y Brunt EM. Hepatic histologic and immunohistochemical changes in chronic hepatitis B after prolonged clearance of hepatitis B e antigen and hepatitis B surface antigen. Ann Intern Med 1991; 115: 113-115.
30. Brunetto MR. Oliven F, Demartini A et al. Treatment with interferon of chronic hepatitisB associated with antibody to hepatitis B e antigen. J Hepatol 1991; 13: S8-S11.
31. Hadziyannis S, Bramou T, Makris A et al. Interferon alfa2b treatment of HBeAg negative/serum HBVDNA positive chronic active hepatitis type B. J Hepatol 1990; 11: S133-S136.