Apoptosis induction in human leukemic cells by topoisomerase I and II inhibitors;APOPTOSE DES CELLULES LEUCEMIQUES HUMAINES INDUITE PAR LES INHIBITEURS DE TOPO-ISOMERASE I ET II

Bulletin du Cancer

Volumn 83, Issue 3, 1996, Pages 205-212

  Solary, E ^a   Dubrez, L ^a   Eymin, B ^a   Bertrand, R ^b   Pommier, Y ^c  

^a Lab d'Oncohematologie Pharmacologie   (France)

^b Institut du Cancer de Montreal   (Canada)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

apoptosis; cell cycle; leukemia; proteases; topoisomerases

Indexed keywords

3 AMINOBENZAMIDE; AURINTRICARBOXYLIC ACID; CAMPTOTHECIN; ETOPOSIDE; GYRASE INHIBITOR; ISOMERASE INHIBITOR; SPERMINE; VINBLASTINE; ZINC SULFATE; ALKALOID; DNA; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); PROTEIN KINASE C; STAUROSPORINE;

APOPTOSIS; ARTICLE; CELL CYCLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; CELL CULTURE; CELL DIFFERENTIATION; DRUG ANTAGONISM; DRUG EFFECT; LEUKEMIA; PATHOLOGY; SIGNAL TRANSDUCTION;

ALKALOIDS; APOPTOSIS; CAMPTOTHECIN; CELL CYCLE; CELL DIFFERENTIATION; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DNA, NEOPLASM; ETOPOSIDE; HUMANS; LEUKEMIA; PROTEIN KINASE C; SIGNAL TRANSDUCTION; STAUROSPORINE; TUMOR CELLS, CULTURED;

EID: 0030097371     PISSN: 00074551     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Bertrand R, Kohn KW, Solary E, Pommier Y. Detection of apoptosis-associated DNA fragmentation using a rapid and quantitative filter binding assay. Drug Dev Res 1995;34:138-44
2. Bertrand R, Solary E, Jenkins J, Pommier Y. Apoptosis and its modulation in human promyelocytic HL60 cells treated with DNA topoisomerase I and II inhibitors. Exp Cell Res 1993;207:388-97
3. Bertrand R, Solary E, O'Connor P, Kohn KW, Pommier Y. Induction of a common pathway of apoptosis by staurosporine. Exp Cell Res 1994;211:314-21
4. Bicknell GR, Snowden RT, Cohen GM. Formation of high molecular mass DNA fragments is a marker in the human leukaemic cell line, U937. J Cell Sci 1994;107:2483-9
5. Boise L, Gonzalez-Garcia M, Postema C et al. Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 1993;74:597-608
6. Carmichael J, De Graff WG, Gazdar AF, Minna JD, Mitchell JB. Evaluation of tetrazolium based semi-automated colorimetric assay: assessment of chemosensitivity testing. Cancer Res 1987;47:936-42
7. Dubrez L, Goldwasser F, Genne P, Pommier Y, Solary E. The role of cell cycle regulation and apoptosis triggering in determining the sensitivity of leukemic cells to topoisomerase I and II inhibitors. Leukemia 1995;9:1013-24
8. Duguet L, Riou JF. De la topologie de l'ADN aux médicaments antibiotiques et anticancéreux. Méd/Sci 1994;10: 962-72
9. Evans CA, Owen-Lynch PJ, Whetton AD, Dive C. Activation of the Abelson tyrosine kinase activity is associated with suppression of apoptosis in hemopoietic cells. Cancer Res 1993;53:1735-8
10. Kohn KW, Ewig RA, Erickson LC, Zwelling LA. Measurement of strand breaks and crosslinks by alkaline elution. In: Friedberg E and Hanawalt P, eds. DNA repair: A laboratory manual of research procedures. New York: Marcel Dekker Inc, 1981:379-401
11. Lotem J, Sachs L. Regulation by bcl-2, c-myc and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiation-competent and-defective myeloid leukemic cells. Cell Growth Diff 1993;4:41-7
12. McGahon A, Bissonnette R, Schmitt M, Cotter KM, Green DR, Cotter TG. BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death. Blood 1994;83:1179-87
13. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988;16:1215-7
14. Miura M, Zhu H, Rotello R, Hartwieg EA, Yuan J. Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 1993;75:653-60
15. Miyashita T, Reed JC. Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood 1993;81:151-7
16. Noonan KE, Beck C, Holzmayer TA et al. Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction. Proc Natl Acad Sci USA 1990;87:7160-4
17. O'Connor P, Kohn K. A fundamental role for cell cycle regulation in the chemosensitivity of cancer cells. Semin Cancer Biol 1992;8:409-6
18. Oltvai Z, Milliman C, Korsmeyer S. Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell 1993;74:609-19
19. Pommier Y, Leteurtre F, Fesen MR et al. Cellular determinant of sensitivity and resistance to DNA topoisomerase inhibitors. Cancer Invest 1994;12:530-42
20. Shi L, Nishioka WK, Th'ng J, Bradbury EM, Litchfield DW, Greenberg AH. Premature p34cdc2 activation required for apoptosis. Science 1994;263:1143-5
21. Shimizu T, O'Connor PM, Kohn KW, Pommier Y. Unscheduled activation of cyclin B1/Cdc2 kinase in human promyelocytic leukemia cell line HL60 cells undergoing apoptosis induced by DNA damage. Cancer Res 1995;55:228-31
22. Smetsers T, Skorski T, Van de Locht L et al. Antisens BCR-ABL oligonucleotides induce apoptosis in the Philadelphia chromosome-positive cell line BV173. Leukemia 1994;8:129-40
23. Solary E, Bertrand R, Kohn K, Pommier Y. Differential induction of apoptosis in undifferentiated and differentiated HL60 cells by DNA topoisomerase I and II inhibitors. Blood 1993;81:1359-67
24. Solary E, Bertrand R, Pommier Y. Apoptosis induced by DNA topoisomerase I and II inhibitors in human leukemic HL60 cells. Leuk & Lymph 1994;15:21-32
25. Wang L, Miura M, Bergeron L, Zhu H, Yuan J. Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell 1994;78:739-50