Apolipoprotein E ϵ4/4 in a Neuropathologically Normal Very Elderly Individual

Archives of Neurology

Volumn 53, Issue 3, 1996, Pages 215-

  Hyman, Bradley T ^a   Hedley Whyte, E Tessa ^a   Rebeck, G William ^a   Vonsattel, Jean Paul ^a   West, Howard L ^a   Growdon, John H ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E4;

AGED; ALLELE; ALZHEIMER DISEASE; GENOTYPE; HOMOZYGOSITY; LETTER; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SENILE PLAQUE; HUMAN; MEDICAL EDUCATION; MEDICAL STUDENT; NEUROLOGY; NEUROSURGERY; NOTE;

EDUCATION, MEDICAL; HUMANS; NEUROLOGY; NEUROSURGERY; STUDENTS, MEDICAL;

EID: 0030094538     PISSN: 00039942     EISSN: 15383687     Source Type: Journal    
DOI: 10.1001/archneur.1996.00550030017010     Document Type: Letter

References (6)

1. Strittmatter WJ, Saunders AM, Schmechel D, et al. Apolipoprotein E: high-avidity binding to β-amyloid and increased frequence of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci U S A. 1993;90:1977-1981.
2. Corder EH, Saunders AM, Strittmatter WJ, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 1993;261:921-923.
3. Rebeck GW, Perls TT, West HL, Sodhi P, Lipsitz LA, Hyman BT. Reduced apolipoprotein E4 allele frequency in the oldest old Alzheimer's patients and cognitively normal individuals. Neurology. 1994;44:1513-1516.
4. Mayeux R, Tycko B. Apolipoprotein E. Ann Neurol. 1994;35:506-507.
5. Hyman BT, Gomez-Isla T, Briggs M, et al. Influence of APOE genotype on developing cognitive impairment in the general population. Soc Neurosci Abst. 1995;21:1008.
6. Corder EH, Saunders AM, Roses AD. There is a pathologic relationship between ApoE-ϵ4 and Alzheimer's disease. Arch Neurol. 1995;52:650.