Effects of hematocrit and erythrocyte deformability on pulmonary vascular pressures in perfused pony lungs

American Journal of Veterinary Research

Volumn 57, Issue 3, 1996, Pages 346-350

  Weiss, Douglas J ^a   Richwagen, Kristin ^a   Evanson, Oral A ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PENTOXIFYLLINE;

ANIMAL; ARTICLE; BLOOD FLOW VELOCITY; BLOOD PRESSURE; CAPILLARY; DRUG EFFECT; ERYTHROCYTE DEFORMABILITY; HEMATOCRIT; HORSE; IN VITRO STUDY; LUNG; LUNG CIRCULATION; PERFUSION; PHYSIOLOGY; PULMONARY ARTERY; PULMONARY VEIN; VASCULAR RESISTANCE; VASCULAR SMOOTH MUSCLE; VASCULARIZATION;

ANIMALS; BLOOD FLOW VELOCITY; BLOOD PRESSURE; CAPILLARIES; ERYTHROCYTE DEFORMABILITY; HEMATOCRIT; HORSES; LUNG; MUSCLE, SMOOTH, VASCULAR; PENTOXIFYLLINE; PERFUSION; PULMONARY ARTERY; PULMONARY CIRCULATION; PULMONARY VEINS; VASCULAR RESISTANCE;

EID: 0030094387     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Whitwell KE, Greet TRC. Collection of evaluation of tracheobronchial washes in the horse. Equine Vet J 1984,6:499-508.
2. McClay CB, Weiss DJ, Smith CM II, et al Evaluation of hemorheologic variables as implications for exercise-induced pulmonary hemorrhage in racing Thoroughbreds. Am J Vet Res 1992; 53:1380-1385
3. Pascoe JR, Raphel CF. Pulmonary hemorrhage in exercising horses. Compend Contin Educ Pract Vet 1982;4 S411-S415
4. Derksen FJ, Slocombe RF, Grey PR, et al. Exercise-induced pulmonary hemorrhage in horses with experimentally induced allergic lung disease. Am J Vet Res 1992,53 15-21.
5. Gunson DE, Sweeney CR, Soma LR Sudden death attributable to exercise-induced pulmonary hemorrhage in racehorses nine cases (1981-1983). J Am Vet Med Assoc 1988;193:102-106.
6. O'Callaghan MW, Pascoe JR, Tyler WS. Exercise-induced pulmonary hemorrhage in the horse: II Gross lung pathology. Equine Vet J 1987,19:389-393.
7. Costello ML, Mathieu-Costello O, West JB. Stress failure of alveolar epithelial cells studied by scanning electron microscopy. Am Rev Respir Dis 1992;145:1446-1455.
8. West JB, Mathieu-Costello O, Jones JH, et al Stress failure of pulmonary capillaries in racehorses with exercise-induced pulmonary hemorrhage J Appl Physiol 1993,75:1097-1109.
9. Manohar M. Pulmonary artery wedge pressure increases with high-intensity exercise in horses. Am J Vet Res 1993;54:142-146
10. Fedde MR, Ho HH, Wood SC. Oxygen transport in exercising horses: importance of rheological properties of blood. In: Eduardo J, Bicudo PW, eds. The vertebrate gas transport cascade Ann Arbor, Mich: CRC Press, 1993;200-207.
11. Coyne CP, Carlson GP, Spensley MS, et al. Preliminary investigation of alterations in blood viscosity, cellular composition, and electrophoresis plasma protein fraction profile after competitive racing activity in Thoroughbred horses. Am J Vet Res 1990;51:1956-1963.
12. Geor RJ, Weiss DJ, Smith CM II. Hemorheologic alterations induced by incremental treadmill exercise in Thoroughbreds Am J Vet Res 1994;55:854-861.
13. Weiss DJ, Geor RJ, Smith CM II Effects of echinocytosis on hemorheologic values and exercise performance in horses. Am J Vet Res 1994;55:204-210.
14. Weiss DJ, Evanson O, Geor RJ. Filterability of equine erythrocytes and whole blood: effects of haematocrit, pore size, and flow rate. Comp Haematol Int 1994;4:11-16.
15. Davis JL, Manohar M. Effects of splenectomy on exercise-induced pulmonary and systemic hypertension in ponies. Am J Vet Res 1988;49:1169-1172.
16. Somer T, Meiselman HJ. Disorders of blood viscosity. Ann Med 1993;25:31-39.
17. Weiss DJ, Evanson OA, Geor RJ. The effects of furosemide and pentoxifylline on the flow properties of equine erythrocytes: in vitro studies. Vet Res Commun 1994;18:373-381.
18. Geor RJ, Weiss DJ, Burris SM, et al. Effects of furosemide and pentoxifylline on blood flow properties in horses. Am J Vet Res 1992,53:2043-2049.
19. Ambus JL, Anain LM, Anain SM, et al. Dose-response effects of pentoxifylline on erythrocyte filterability: clinical and animal model studies. Clin Pharmacol Ther 1990;48 50-56.
20. Julien M, Hakin TS, Vahi R, et al. Effects of hematocrit on vascular pressure profile in dog lungs. J Appl Physiol 1985;58:743-748.
21. Andrews FM, Korenck NL, Sanders WL, et al. Viscosity and rheologic properties of blood from clinically normal horses. Am J Vet Res 1992,53.966-970.
22. Pearson TC. Rheology of the absolute polycythemias. Baillieres Clin Haematol 1987;1:637-664.
23. Pascoe JR, McCabe AE, Franti CE, et al. Efficacy of furosemide in the treatment of exercise-induced pulmonary hemorrhage in Thoroughbred racehorses. Am J Vet Res 1985,46:2000-2003
24. Manohar M. Pulmonary vascular pressures of strenuously exercising Thoroughbreds after administration of flunixin meglumine and furosemide Am J Vet Res 1994,55.1308-1312
25. Manohar M, Hutchens E, Coney E Furosemide attenuates the exercise-induced rise in pulmonary capillary blood pressure in horses Equine Vet J 1994,26:51-54.
26. Gustin P, Urbain B, Delaunois A. Permeability of the endothelium and partitioning of the pulmonary blood flow resistance in isolated perfused pig lung: effects of breed and age Vet Res Commun 1992;16:69-82