Quantitative structure-activity relationships of the synthetic substrates for elastase enzyme using nonlinear partial least squares regression

Journal of Chemical Information and Computer Sciences

Volumn 36, Issue 2, 1996, Pages 185-189

  Kimura, Toshiro ^a   Miyashita, Yoshikatsu ^a   Funatsu, Kimito ^a   Sasaki, Shin Ichi ^a  

^a TOYOHASHI UNIVERSITY OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDE; PANCREATIC ELASTASE;

AMINO ACID SEQUENCE; ARTICLE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; HUMAN; IN VITRO STUDY; KINETICS; METABOLISM; NONLINEAR SYSTEM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMINO ACID SEQUENCE; DIPEPTIDES; HUMANS; KINETICS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; NONLINEAR DYNAMICS; PANCREATIC ELASTASE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 0030094196     PISSN: 00952338     EISSN: None     Source Type: Journal    
DOI: 10.1021/ci9501103     Document Type: Article

References (7)

1. Geladi, P.; Kowalski, B. R. Partial Least-Squares Regression: A Tutorial. Anal. Chim. Acta 1986, 185, 1-17.
2. Höskuldsson, A. PLS Regression Methods. J. Chemometrics 1988, 2, 211-228.
3. Helland, I. S. On the Structure of Partial Least Squares Regression. Commun. Statist.-Simula. 1988, 17(2), 581-607.
4. Wold, S.; Wold, N. K.; Skagerberg, B. Nonlinear PLS Modelling. Chemometrics Intell. Lab. Syst. 1989, 7, 53-65.
5. Nomizu, M.; Iwaki, T.; Yamashita, T.; Inagaki, Y.; Asano. K.; Akamatsu, M.; Fujita, T. Quantitative structure-activity relationship-(QSAR) study of elastase substrates and inhibitors. Int. J. Peptide Protein Res. 1993, 42, 216-226.
6. Hellberg, S.; Sjöström, M.; Skagerberg, B.; Wold, S. Peptide Quantitative Structure-Activity Relationships, a Multivariate Approach. J. Med. Chem. 1987, 30, 1126-1135.
7. Wold, S.; Eriksson, L.; Hellberg, S.; Jonsson, J.; Sjöström, M.; Skagerberg, B.; Wikström, C. Principal property values for six non-natural amino acids and their application to a structure-activity relationships for oxytocin peptide analogues. Can. J. Chem. 1987, 65, 1814-1820.